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公开(公告)号：US20200332022A1
公开(公告)日：2020-10-22
申请号：US16783720
申请日：2020-02-06
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Joost J. NEIJSSEN , Edward Norbert VAN DEN BRINK , Janine SCHUURMAN , Paul PARREN
Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.
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公开(公告)号：US20200247899A1
公开(公告)日：2020-08-06
申请号：US16855703
申请日：2020-04-22
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , A61K39/395 , G01N33/569
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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公开(公告)号：US20200239579A1
公开(公告)日：2020-07-30
申请号：US16491464
申请日：2018-03-09
Applicant: GENMAB A/S
Inventor： Isil ALTINTAS , David SATIJN , Edward VAN DEN BRINK , Dennis VERZIJL , Rik RADEMAKER , Paul PARREN , Bart DE GOEIJ
IPC: C07K16/28 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/42
Abstract: The present invention relates to novel antibodies and their use in medicine. In particular, the invention relates to bispecific antibodies capable of binding human PD-L1 and capable of binding human CD3. Novel classes of antibodies capable of binding human PD-L1 are also provided. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20200171152A1
公开(公告)日：2020-06-04
申请号：US16673383
申请日：2019-11-04
Applicant: GENMAB A/S
Inventor： Esther BREIJ , David SATIJN , Edward Norbert VAN DEN BRINK , Dennis VERZIJL , Rob N. DE JONG , Paul PARREN , Riemke VAN DIJKHUIZEN RADERSMA
IPC: A61K39/395 , C07K16/28 , A61K47/68 , C07K16/30
Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
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公开(公告)号：US20190352423A1
公开(公告)日：2019-11-21
申请号：US16072437
申请日：2017-02-03
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Joost MELIS , Tom VINK , Hendrik TEN NAPEL , Esther BREIJ , David SATIJN , Paul PARREN
Abstract: The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10−9 and 10−8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.
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Patent Agency Ranking
公开(公告)号：US20190315880A1
公开(公告)日：2019-10-17
申请号：US16367933
申请日：2019-03-28
Applicant: GENMAB A/S
Inventor： David SATIJN , Sandra VERPLOEGEN , Wim BLEEKER , Steen LISBY , Jan VAN DE WINKEL , Patrick VAN BERKEL , Paul PARREN
Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.
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公开(公告)号：US20190169298A1
公开(公告)日：2019-06-06
申请号：US16183300
申请日：2018-11-07
Applicant: GENMAB A/S
Inventor： Paul PARREN , Janine SCHUURMAN , Tom VINK , Willem Karel BLEEKER , Jan VAN DE WINKEL , Patrick VAN BERKEL , Frank BEURSKENS
IPC: C07K16/28
Abstract: The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
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公开(公告)号：US20180022816A1
公开(公告)日：2018-01-25
申请号：US15627921
申请日：2017-06-20
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Edward N. VAN DEN BRINK , Simone DE HAIJ , Thilo RIEDL , Rene HOET , Ole BAADSGAARD, D.M.Sc. , David SATIJN , Jan VAN DE WINKEL , Paul PARREN
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20170313782A1
公开(公告)日：2017-11-02
申请号：US15484583
申请日：2017-04-11
Applicant: GENMAB A/S
Inventor： Joost J. NEIJSSEN , Bart DE GOEIJ , Edward Norbert VAN DEN BRINK , Aran Frank LABRIJN , Rene HOET , Janine SCHUURMAN , Paul PARREN , Jan VAN DE WINKEL
IPC: C07K16/30 , A61K45/06 , C07K16/40 , A61K39/395 , G01N33/574 , C07K16/28 , A61K39/00
Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20170173151A1
公开(公告)日：2017-06-22
申请号：US15366791
申请日：2016-12-01
Applicant: GENMAB A/S
Inventor： Sandra VERPLOEGEN , Marije OVERDIJK , Riemke van DIJKHUIZEN , Willem Karel BLEEKER , Patrick VAN BERKEL , Paul PARREN , Steen LISBY
IPC: A61K39/395
CPC classification number: A61K39/39541 , A61K31/7088 , A61K35/17 , A61K35/76 , A61K38/162 , A61K38/19 , A61K39/39533 , A61K39/39566 , A61K45/06 , A61K47/6849 , A61K51/1027 , A61K2039/505 , A61K2121/00 , C07K16/18 , C07K16/2833 , C07K2317/21 , C07K2317/33 , C07K2317/73 , C07K2317/77 , C07K2317/92
Abstract: Isolated human monoclonal antibodies which bind to human CD74 and related antibody-drug conjugates are disclosed. Pharmaceutical compositions comprising the antibodies or antibody-drug conjugates, and therapeutic and diagnostic methods for using the antibodies and/or antibody-drug conjugates, are also disclosed.
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