公开(公告)号：US06397182B1

公开(公告)日：2002-05-28

申请号：US09414855

申请日：1999-10-12

Applicant: Brian Cruickshank ,  Pierre M. Forgues ,  Lin Lin

Inventor： Brian Cruickshank ,  Pierre M. Forgues ,  Lin Lin

IPC: G10L1514

CPC classification number: G10L15/063 ,  G10L15/144 ,  G10L2015/0631 ,  Y10S379/902 ,  Y10S379/907 ,  Y10S379/913

Abstract: A system and a method for generating a speech recognition dictionary that can be used in a telephone system having speech recognition capabilities, in particular capabilities to effect a connection when the calling party utters the name of a subscriber (called party). The method generates transcriptions associated to respective vocabulary items in the speech recognition dictionary from audio greetings recorded by the telephone system subscribers. Normally such audio greetings are used in voice messaging applications. Typically, the greetings are played before allowing callers to leave messages in a voice mailbox of subscribers. An individual greeting is audio information that contains the name of the subscriber. This audio information is processed to generate a transcription associated to a vocabulary item in the speech recognition dictionary, representative of the subscriber name.

Abstract translation: 一种用于产生可用于具有语音识别能力的电话系统中的语音识别词典的系统和方法，特别是当呼叫方发出用户（被叫方）的名称时进行连接的能力。 该方法从由电话系统用户记录的音频问候产生与语音识别词典中的各个词汇项相关联的转录。 通常这种音频问候语用于语音消息应用。 通常，在允许呼叫者将消息留在订户的语音邮箱中之前播放问候语。 个人问候语是包含用户名称的音频信息。 处理该音频信息以生成与语音识别词典中的词汇项相关联的表示代表用户名称的转录。

公开(公告)号：US5869324A

公开(公告)日：1999-02-09

申请号：US933619

申请日：1997-09-08

Applicant: Michael T. Flavin ,  Ze-Qi Xu ,  John D. Rizzo ,  Alla Kucherenko ,  Albert Khilevich ,  Abram Kivovich Sheinkman ,  Vilayphone Vilaychack ,  Lin Lin ,  Wei Chen ,  William A. Boulanger

Inventor： Michael T. Flavin ,  Ze-Qi Xu ,  John D. Rizzo ,  Alla Kucherenko ,  Albert Khilevich ,  Abram Kivovich Sheinkman ,  Vilayphone Vilaychack ,  Lin Lin ,  Wei Chen ,  William A. Boulanger

IPC: C07D311/58 ,  A61K31/365 ,  A61K45/06 ,  A61P31/12 ,  A61P37/04 ,  C07D311/16 ,  C07D493/04 ,  C07D493/14 ,  C12P41/00

CPC classification number: C07D493/04 ,  A61K45/06 ,  C07D311/16 ,  C07D493/14

Abstract: A method of preparing (.+-.)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (.+-.)-calanolide A and its derivatives are also provided. According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal or paraldehyde in the presence of an acid catalyst with heating, or a two-step reaction including an aldol reaction with acetaldehyde and cyclization either under acidic conditions or neutral Mitsunobu conditions, to produce chromanone 7. Reduction of chromanone 7 with sodium borohydride, in the presence of cerium trichloride, produced (.+-.)-calanolide A. A method for resolving (.+-.)-calanolide A into its optically active forms by a chiral HPLC system or by enzymatic acylation and hydrolysis is also disclosed. Finally, a method for treating or preventing viral infections using (.+-.)-calanolide A or (-)-calanolide A is provided.

Abstract translation: 提供了从色烯4制备（+/-） - 丙内酰脲A，1，一种有效的HIV逆转录酶抑制剂的方法。 还提供了制备（+/-） - 丙内酰脲A及其衍生物的有用中间体。 根据所公开的方法，在酸催化剂的存在下，将色烯4中间体与乙醛二乙基缩醛或对甲醛反应，或者在酸性条件或中性Mitsunobu条件下，包括醛醇与乙醛反应和醛化反应的两步反应， 产生苯并二氢吡喃酮7.在三氯化铈的存在下，用硼氢化钠还原色酮7.产生（+/-） - 甘露糖苷A。一种通过手性拆分（+/-） - 卡立拉内酯A至其光学活性形式的方法 还公开了HPLC系统或通过酶酰化和水解。 最后，提供了一种使用（+/-） - 蒎烯内酰胺A或（ - ） - cal醇酯A治疗或预防病毒感染的方法。