公开(公告)号：US20080072301A1

公开(公告)日：2008-03-20

申请号：US11631625

申请日：2005-07-11

申请人： Pei Chia ,  Hong Cheng

发明人： Pei Chia ,  Hong Cheng

IPC分类号： G06F17/30

CPC分类号： H04L63/0815 ,  G06F21/41

摘要： A single-sign-on to access multiple networks residing at multiple domains is disclosed. In particular the single-sign-on features refers to the authentication and the authorization process carried out among the different network administration domains so that the terminal using the end service need not explicitly initiate the authentication process each time it accesses a new service. This invention's single-sign-on feature can be extended for usage in a federated domain environment and non-federated domain environment. The non-federated domains are able to form an indirect federation chain through other domains in order to utilize this invention. Therefore discovery of intermediate domains to form a federation chain is also covered. The management of user credentials to allow a Visited Domain to perform authentication is also covered in this invention.

摘要翻译： 公开了访问驻留在多个域的多个网络的单点登录。 特别地，单点登录功能是指在不同网络管理域之间执行的认证和授权过程，使得使用终端服务的终端在每次访问新服务时都不需要明确地启动认证过程。 本发明的单点登录功能可以扩展到在联盟域环境和非联盟域环境中的使用。 非联合域能够通过其他域形成间接联合链，以利用本发明。 因此，也涵盖了形成联合链的中间域的发现。 访问域进行身份验证的用户凭据的管理也在本发明中被覆盖。

公开(公告)号：US6143931A

公开(公告)日：2000-11-07

申请号：US61752

申请日：1998-04-16

申请人： Carmen M. Baldino ,  David L. Coffen ,  Stewart D. Chipman ,  Hong Cheng

发明人： Carmen M. Baldino ,  David L. Coffen ,  Stewart D. Chipman ,  Hong Cheng

IPC分类号： C07B61/00 ,  C07C275/40 ,  C07C335/20 ,  C07D333/60 ,  C07C233/00

CPC分类号： C40B40/04 ,  C07C275/40 ,  C07C335/20 ,  C07D333/60

摘要： The invention is based on new methods for making and using compounds and arrays of novel .alpha.-ketoamides, and the arrays and compounds made by these methods. These novel compounds are potential inhibitors of proteolytic enzymes, particularly cysteine proteases such as cruzain. Application of the new methods has led to the identification of a number of new inhibitors, from amongst an array of about 38,000 .alpha.-ketoamide derivatives, having specific activity against three cysteine proteases: cruzain, papain, and cathepsin B. These compounds and other compounds identified by the methods described herein can be useful, for example, in developing pharmaceutic agents for the treatment of diseases (e.g., Chagas' disease) associated with these proteases. Although the disclosed compounds have specific activity for cruzain, papain, cathepsin B, the methods described herein can also be used to identify inhibitors of other proteases.

摘要翻译： 本发明基于制备和使用新型α-酮酰胺的化合物和阵列的新方法，以及通过这些方法制备的阵列和化合物。 这些新型化合物是蛋白水解酶的潜在抑制剂，特别是半胱氨酸蛋白酶如克鲁津。 新方法的应用已经导致了一系列新的抑制剂的鉴定，其中有大约38,000种α-酮酰胺衍生物，具有针对三种半胱氨酸蛋白酶：克鲁津，木瓜蛋白酶和组织蛋白酶B的比活性。这些化合物和其它化合物 通过本文描述的方法鉴定可用于例如开发用于治疗与这些蛋白酶相关的疾病（例如恰加斯病）的药物制剂。 虽然所公开的化合物对克鲁津，木瓜蛋白酶，组织蛋白酶B具有比活性，但本文所述的方法也可用于鉴定其它蛋白酶的抑制剂。