公开(公告)号：US20090027050A1

公开(公告)日：2009-01-29

申请号：US12210342

申请日：2008-09-15

申请人： Michael Garwood ,  Djaudat S. Idiyatullin ,  Curt Corum ,  Steen Moeller

发明人： Michael Garwood ,  Djaudat S. Idiyatullin ,  Curt Corum ,  Steen Moeller

IPC分类号： G01R33/48

CPC分类号： G01N24/10 ,  G01N24/081 ,  G01R33/441 ,  G01R33/446 ,  G01R33/4616 ,  G01R33/4816 ,  G01R33/54

摘要： A method of magnetic resonance is provided that uses a frequency swept excitation wherein the acquired signal is a time domain signal is provided. In one embodiment, the method comprises, applying a sweeping frequency excitation and acquiring a time domain signal. The sweeping frequency excitation has a duration and is configured to sequentially excite isochromats having different resonant frequencies. Acquisition of the time domain signal is done during the duration of the sweeping frequency excitation. The time domain signal is based on evolution of the isochromats.

摘要翻译： 提供了一种磁共振的方法，其使用频率扫描激励，其中提供所获取的信号是时域信号。 在一个实施例中，该方法包括：施加扫频激励并获取时域信号。 扫频频率激励具有持续时间并且被配置为顺序地激发具有不同谐振频率的异色素。 在扫描频率激励的持续时间内完成时域信号的采集。 时域信号是基于异色素的进化。

公开(公告)号：US20080164874A1

公开(公告)日：2008-07-10

申请号：US11983393

申请日：2007-11-08

申请人： James White ,  Christopher White

发明人： James White ,  Christopher White

IPC分类号： G01N24/10

CPC分类号： G01N24/08 ,  G01N24/10 ,  G01R33/307 ,  G01R33/34 ,  G01R33/343 ,  G01R33/345 ,  G01R33/60 ,  H01P7/06

摘要： A miniaturized instrument and method of using electron spin resonance spectrometry for measuring the degradation of lubricating fluids, and the like, that includes continuously passing a sample of such fluid through a resonating RF microwave cavity resonator during the application therethrough of a uniform slowly varying uniform magnetic field that is rapidly modulated and measuring the resulting phase modulation or amplitude modulation thereof to derive an electron spin resonance signal that directly senses the molecular changes in the fluid sample resulting from fluid degradation during operation of the vehicle, such as peroxy radicals in vehicle engine oil and the like.

摘要翻译： 使用电子自旋共振光谱测量法来测量润滑流体的劣化的小型化仪器和方法等，其包括在施加期间连续地将这种流体的样品通过谐振RF微波腔谐振器通过其中均匀缓慢变化的均匀磁 场，其被快速调制并测量所得到的相位调制或幅度调制，以导出电子自旋共振信号，其直接感测由车辆运行期间的流体降解导致的流体样品中的分子变化，例如车辆发动机油中的过氧自由基 等等。

公开(公告)号：US20070159175A1

公开(公告)日：2007-07-12

申请号：US10587447

申请日：2005-01-14

申请人： Menno Prins

发明人： Menno Prins

IPC分类号： G01V3/00

CPC分类号： G01N15/0656 ,  G01N24/10 ,  G01R33/28 ,  G01R33/3806 ,  G01R33/60

摘要： A method and a device for on-chip magnetic resonance spectroscopy (FMR, SPR, EPR, ESR, NMR) is proposed. On-chip magnetic resonance spectroscopy may be applied to non-magnetic as well as magnetic materials and to solids, liquids and gases. The method of the present invention is suitable for miniaturised materials analysis such as for example microfluidics. The strength of the method lies in the combination of highly efficient spin excitation near on-chip current wires with very sensitive on-chip magnetic sensors. The method and device also allows to separately detect different types of magnetic particles or molecules.

摘要翻译： 提出了片上磁共振波谱法（FMR，SPR，EPR，ESR，NMR）的方法和装置。 片上磁共振光谱可以应用于非磁性以及磁性材料以及固体，液体和气体。 本发明的方法适用于小型化材料分析，例如微流体。 该方法的强度在于在片上电流线附近具有非常灵敏的片上磁传感器的高效旋转激发。 该方法和装置还允许分别检测不同类型的磁性颗粒或分子。

公开(公告)号：US07148683B2

公开(公告)日：2006-12-12

申请号：US10833186

申请日：2004-04-28

申请人： Xiao Dong Xiang ,  Haitao Yang ,  Gang Wang

发明人： Xiao Dong Xiang ,  Haitao Yang ,  Gang Wang

IPC分类号： G01V3/00

CPC分类号： G01R33/60 ,  G01N24/00 ,  G01N24/006 ,  G01N24/08 ,  G01N24/10 ,  G01R33/345

摘要： Methods and systems for spatially resolved spin resonance detection in a sample of material are disclosed. Also disclosed are methods and systems for spatially resolved impedance measurements in a sample of material. The disclosed methods and samples can be used in screening of plurality of biological, chemical and material samples.

摘要翻译： 公开了用于材料样品中空间分辨的自旋共振检测的方法和系统。 还公开了用于材料样品中的空间分辨阻抗测量的方法和系统。 所公开的方法和样品可用于筛选多个生物，化学和物质样品。

公开(公告)号：US07109706B2

公开(公告)日：2006-09-19

申请号：US11216931

申请日：2005-08-30

申请人： Xiao-Dong Xiang ,  Haitao Yang

发明人： Xiao-Dong Xiang ,  Haitao Yang

IPC分类号： G01V3/00

CPC分类号： G01R33/60 ,  G01N24/10 ,  G01Q30/02 ,  G01Q60/12 ,  G01R33/26 ,  G01R33/323 ,  G01R33/4808

摘要： A novel spin resonance microscope is disclosed, the microscope design comprising an integrated evanescent wave probe and scanning tunneling microscope tip. The probe and tip may be either the same structure, or they may be separate structures. The integrated design allows for coherent excitation of precessing electron spin states in the sample such that spin resonance may be detected because the tunneling current is modulated by the spin resonance. Spin resonance may be affected by either adjacent nuclei, or by adjacent electrons. The present apparatus requires significantly reduced power inputs, such that the dead time of the system is short, and relaxation phenomena may be evaluated without swamping the instrument's electronics.

摘要翻译： 公开了一种新型的自旋共振显微镜，显微镜设计包括集成的ev逝波探针和扫描隧道显微镜尖端。 探针和尖端可以是相同的结构，或者它们可以是分离的结构。 该集成设计允许在样品中进行电子自旋状态的相干激发，使得可以检测自旋共振，因为隧道电流被自旋共振调制。 旋转共振可能受相邻核或相邻电子的影响。 本装置需要显着降低的功率输入，使得系统的死区时间短，并且可以评估松弛现象而不会使仪器的电子元件变形。

公开(公告)号：US07084628B2

公开(公告)日：2006-08-01

申请号：US10731552

申请日：2003-12-08

申请人： Harold M. Swartz ,  William F. B. Punchard ,  Piotr M. Starewicz ,  Tadeusz M. Walczak

发明人： Harold M. Swartz ,  William F. B. Punchard ,  Piotr M. Starewicz ,  Tadeusz M. Walczak

IPC分类号： G01V3/00

CPC分类号： G01R33/60 ,  G01N24/10 ,  G01T1/04

摘要： The instant invention provides in-vivo methods and apparatus for radiation dosimetry assessment in individuals exposed to potentially harmful radiation, based on measurements in-situ of the teeth. The in vivo dosimetry assessment methods and apparatus utilize electron paramagnetic resonance (EPR) techniques; and employ an apparatus comprising an integrated EPR spectrometer system, an ergonomic magnet and a constructed resonator structure. In various aspects, the dosimetry assessment apparatus is configured to be easily portable and withstand potentially adverse mechanical effects of transportation and deployment in the field. The apparatus also is configured with a power supply that is compatible with both conventional AC line voltages and/or other sources of power suitable for field conditions; and may be easily operated by minimally trained technicians to quickly generate a readout of estimated radiation exposure dose.

摘要翻译： 本发明提供了基于在牙齿原位测量的暴露于潜在有害辐射的个体中的放射剂量测定评估的体内方法和装置。 体内剂量学评估方法和装置利用电子顺磁共振（EPR）技术; 并采用包括集成EPR光谱仪系统，符合人体工程学的磁体和构造的谐振器结构的装置。 在各个方面，剂量测定评估装置被配置为容易携带并且承受在现场的运输和部署的潜在不利的机械效应。 该装置还配置有与常规AC线路电压和/或适用于现场条件的其它电源兼容的电源; 并且可以由训练有素的技术人员容易地操作以快速产生估计的辐射照射剂量的读数。

公开(公告)号：US20060071662A1

公开(公告)日：2006-04-06

申请号：US11216931

申请日：2005-08-30

申请人： Xiao-Dong Xiang ,  Haitao Yang

发明人： Xiao-Dong Xiang ,  Haitao Yang

IPC分类号： G01V3/00

CPC分类号： G01R33/60 ,  G01N24/10 ,  G01Q30/02 ,  G01Q60/12 ,  G01R33/26 ,  G01R33/323 ,  G01R33/4808

摘要： A novel spin resonance microscope is disclosed, the microscope design comprising an integrated evanescent wave probe and scanning tunneling microscope tip. The probe and tip may be either the same structure, or they may be separate structures. The integrated design allows for coherent excitation of precessing electron spin states in the sample such that spin resonance may be detected because the tunneling current is modulated by the spin resonance. Spin resonance may be affected by either adjacent nuclei, or by adjacent electrons. The present apparatus requires significantly reduced power inputs, such that the dead time of the system is short, and relaxation phenomena may be evaluated without swamping the instrument's electronics.

公开(公告)号：US06924150B1

公开(公告)日：2005-08-02

申请号：US10124203

申请日：2002-04-17

申请人： Xiao Dong Xiang ,  Gerald F. Dionne ,  Haitao Yang

发明人： Xiao Dong Xiang ,  Gerald F. Dionne ,  Haitao Yang

IPC分类号： G01N24/00 ,  G01N24/10 ,  A61B5/055 ,  A61B8/00 ,  G01N25/18 ,  G01R33/00 ,  G01V3/00

CPC分类号： G01N24/10 ,  G01N24/006 ,  Y10T436/24

摘要： A method for improving the magnetic resonance imaging contrast of a selected portion of a sample. A selected ferrimagnetic constituent is associated with the sample portion, by molecular or biological attachment or by some other means, so that the sample portion is distinguished from other adjacent portions of the sample that do not have the selected ferrimagnetic constituent associated therewith. Alternatively, the sample portion is suspected, but not yet confirmed, to have the selected ferrimagnetic constituent associated with it. Ferromagnetic resonance imaging is performed on the sample portion, and at least one resonance frequency ω0 of the sample portion is provided. At least one material parameter of the sample portion is measured at or near the frequency ω0, with enhanced imaging contrast relative to adjacent portions of the sample that do not have the selected ferrimagnetic constituent in association. Alternatively, the measured value is compared with a corresponding reference value for the selected ferrimagnetic constituent. If (and only if) the measured and corresponding reference values substantially agree, the selected ferrimagnetic constituent is present in association with the selected sample portion. Other parameters of the selected ferrimagnetic consituent can also be measured.

摘要翻译： 一种用于改善所选部分样品的磁共振成像对比度的方法。 选择的亚铁磁性成分通过分子或生物附着或通过某种其他方式与样品部分相关联，使得样品部分与样品中没有与其相关联的选择的亚铁磁性成分的其它相邻部分区分开。 或者，怀疑但尚未确认样品部分具有与其相关联的所选择的亚铁磁性成分。 对样品部分进行铁磁共振成像，并且提供样品部分的至少一个共振频率ω0。 样品部分的至少一个材料参数在频率ω0处或附近被测量，相对于没有关联的选择的亚铁磁性成分的样品的相邻部分，具有增强的成像对比度。 或者，将测量值与所选择的亚铁磁性成分的相应参考值进行比较。 如果（且仅当）测量的和相应的参考值基本一致，则所选择的亚铁磁成分与选择的样品部分相关联地存在。 也可以测量所选铁氧体成分的其它参数。

公开(公告)号：US06693426B1

公开(公告)日：2004-02-17

申请号：US10071563

申请日：2002-02-09

申请人： Xiao Dong Xiang ,  Gang Wang ,  Haitao Yang ,  Gerald F. Dionne

发明人： Xiao Dong Xiang ,  Gang Wang ,  Haitao Yang ,  Gerald F. Dionne

IPC分类号： G01V300

CPC分类号： G01N24/10 ,  G01N24/006 ,  Y10T436/24

摘要： Methods for spatially resolve spin resonance detection in a sample of material, with a resolution as small as 0.5 &mgr;m-1 mm. In one embodiment, a coupler having at least one pair of degenerate orthogonal modes provides an evanescent input signal along one coupler axis to the sample, to which a magnetic field is applied, and senses a spin interaction signal along another coupler axis. In another embodiment, an evanescent input signal is applied to the sample along one of two identical transmission line resonators, and a difference of the two resonator signals provides a spin interaction signal. In another embodiment, a polarized laser beam provides an evanescent input signal to the sample, and the spin interaction signal is sensed according to a second beam polarization direction. Certain ferromagnetic or ferrimagnetic molecules, such as YIG, can be used to tag selected chemical and biological molecules, using spatially resolved spin resonance detection for interrogation.

摘要翻译： 在材料样品中空间分辨自旋共振检测的方法，分辨率小至0.5 mum-1 mm。 在一个实施例中，具有至少一对简并正交模式的耦合器提供沿着一个耦合器轴线向被施加磁场的样本的消逝输入信号，并且沿另一个耦合器轴线感测自旋相互作用信号。 在另一个实施例中，沿着两个相同的传输线谐振器中的一个将消逝的输入信号施加到样本，并且两个谐振器信号的差提供自旋相互作用信号。 在另一个实施例中，偏振激光束向样本提供消逝的输入信号，并且根据第二光束偏振方向感测自旋相互作用信号。 某些铁磁或亚铁磁分子，如YIG，可用于标记选定的化学和生物分子，使用空间分辨的自旋共振检测进行询问。

公开(公告)号：US20030089158A1

公开(公告)日：2003-05-15

申请号：US10303742

申请日：2002-11-26

申请人： COSMO ACE CO

发明人： Tetsurou Nishimoto ,  Masahiro Kohno

IPC分类号： G01N037/00

CPC分类号： G01N1/2205 ,  G01N24/10 ,  G01N2001/2223 ,  G01R33/60

摘要： The present invention provides a method for determining suspended particulate matter accurately and conveniently, a sampling tube for sampling the suspended particulate matter, and a sampling kit for using the collection of the suspended particulate materials. In the present invention, the exhaust emission is passed through a collection material to adsorb the suspended particulate matter in the exhaust emission on it. Then, the amounts of the atoms or the molecular species having unpaired electrons contained in the suspended particulate matter adsorbed on the collection material are determined by using Electron Spin Resonance spectroscopy. The amounts of the suspended particulate matter contained in the exhaust emission may be accurately and conveniently obtained, based on the amounts of the atoms or the molecular species determined above.

摘要翻译： 本发明提供了一种用于准确和方便地测定悬浮颗粒物质的方法，用于对悬浮颗粒物进行取样的采样管和用于使用悬浮颗粒材料收集的采样套件。 在本发明中，废气排放物通过收集材料，以吸附其上的废气排放物中的悬浮颗粒物质。 然后，通过使用电子自旋共振光谱测定吸附在收集材料上的悬浮颗粒物质中所含的不成对电子的原子或分子种类的量。 基于上述确定的原子量或分子种类，可以准确地和方便地获得废气排放中所含的悬浮颗粒物的量。