公开(公告)号：US20090186072A1

公开(公告)日：2009-07-23

申请号：US12009443

申请日：2008-01-18

申请人： Jamal S. Yanaki

发明人： Jamal S. Yanaki

IPC分类号： A61K9/70

CPC分类号： A61N1/303 ,  A61K9/7023 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/08 ,  A61N1/325

摘要： An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face and electrically conductively engage the skin. A detector monitors iontophoretic medicament migration into the skin. An integrator operating on the output of the detector produces a running cumulative total of the amount of medicament delivered during a plurality of temporally non-contiguous therapy subsessions. A circuit breaker terminates medicament migration, when the output of the integrator equals a predetermined medicament quantity. A timer active during medicament migration stimulates a driver to operate a light-emitting diode in a distinct delivery confirmation mode during each a sequence of non-overlapping predetermined therapy subsessions, respectively. A circuit board on the substrate in a compact, folded state bears interconnected electrical circuit components.

摘要翻译： 活性透皮药物贴片包括具有可释放地保持抵抗患者皮肤的治疗面的平面基底。 容易受药物渗透的返回电极和药物基质固定在治疗面上的分离位置处并导电地接合皮肤。 检测器监测离子电渗药物迁移到皮肤中。 在检测器的输出上操作的积分器产生在多个时间不连续的治疗子事件期间递送的药物的累计运行量。 当积分器的输出等于预定的药物量时，断路器终止药物迁移。 在药物迁移期间激活的计时器分别刺激驾驶员在每个不重叠的预定疗法子进程序列期间以不同的递送确认模式操作发光二极管。 紧凑的折叠状态的基板上的电路板具有互连的电路部件。