公开(公告)号：US20080188791A1

公开(公告)日：2008-08-07

申请号：US11701749

申请日：2007-02-02

申请人： Attilio E. DiFiore ,  Jamal S. Yanaki

发明人： Attilio E. DiFiore ,  Jamal S. Yanaki

IPC分类号： A61N1/30

CPC分类号： A61N1/303

摘要： A fully integrated, independently accurately performing, active transdermal medicament patch includes a flexible substrate with an adhesive-coated therapeutic face carrying a medicament reservoir. A circuit non-removably carried on the substrate and driven by a light-weight power source causes a substantially constant current to flow for a predetermined therapy period through the reservoir and the skin against which the therapeutic face is disposed. Net electrical polarity of the medicament determines the interconnection of circuit and power source to skin. The circuit includes a field effect transistor or an operational amplifier with a zener diode or a voltage regulator. A timer non-removably carried on the substrate disables the circuit following functioning the therapy period. An active transdermal medicament delivery system employs a single patch or pair of patches physically and electrically connected by a distensible tether.

摘要翻译： 完全整合的，独立准确地执行的活性透皮药物贴片包括具有携带药物储存器的粘合剂涂覆的治疗面的柔性基底。 不可拆卸地承载在基板上并由轻量电源驱动的电路使得基本上恒定的电流通过储存器和治疗面设置的皮肤流过预定的治疗周期。 药物的净电极性确定电路和电源与皮肤的互连。 该电路包括场效应晶体管或具有齐纳二极管或电压调节器的运算放大器。 不可拆卸地携带在基板上的计时器在治疗期间起作用后使电路不起作用。 活性透皮药物递送系统采用单个贴片或一对贴片，其通过可扩张系绳物理和电连接。

公开(公告)号：US09913973B2

公开(公告)日：2018-03-13

申请号：US13868909

申请日：2013-04-23

申请人： Jamal S. Yanaki

发明人： Jamal S. Yanaki

IPC分类号： A61N1/00 ,  A61N1/04 ,  A61N1/36

CPC分类号： A61N1/0456 ,  A61N1/048 ,  A61N1/0496 ,  A61N1/36014 ,  A61N1/36025

摘要： The present invention generally relates to the use of electrodes with human and animal subjects. More particularly, the present invention relates to electrical contacts which are applied to the surface of a subject for the purpose of delivering transranial direct current stimulation (TDCS).

公开(公告)号：US08862223B2

公开(公告)日：2014-10-14

申请号：US12009443

申请日：2008-01-18

申请人： Jamal S. Yanaki

发明人： Jamal S. Yanaki

IPC分类号： A61N1/30 ,  A61K9/00 ,  A61N1/04 ,  A61K9/70 ,  A61N1/32

CPC分类号： A61N1/303 ,  A61K9/7023 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/08 ,  A61N1/325

摘要： An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face and electrically conductively engage the skin. A detector monitors iontophoretic medicament migration into the skin. An integrator operating on the output of the detector produces a running cumulative total of the amount of medicament delivered during a plurality of temporally non-contiguous therapy subsessions. A circuit breaker terminates medicament migration, when the output of the integrator equals a predetermined medicament quantity. A timer active during medicament migration stimulates a driver to operate a light-emitting diode in a distinct delivery confirmation mode during each a sequence of non-overlapping predetermined therapy subsessions, respectively. A circuit board on the substrate in a compact, folded state bears interconnected electrical circuit components.

摘要翻译： 活性透皮药物贴片包括具有可释放地保持抵抗患者皮肤的治疗面的平面基底。 容易受药物渗透的返回电极和药物基质固定在治疗面上的分离位置处并导电地接合皮肤。 检测器监测离子电渗药物迁移到皮肤中。 在检测器的输出上操作的积分器产生在多个时间不连续的治疗子事件期间递送的药物的累计运行量。 当积分器的输出等于预定的药物量时，断路器终止药物迁移。 在药物迁移期间激活的计时器分别刺激驾驶员在每个不重叠的预定疗法子进程序列期间以不同的递送确认模式操作发光二极管。 紧凑的折叠状态的基板上的电路板具有互连的电路部件。

公开(公告)号：US20080305154A1

公开(公告)日：2008-12-11

申请号：US11811241

申请日：2007-06-08

申请人： Jamal S. Yanaki

发明人： Jamal S. Yanaki

IPC分类号： A61F13/00 ,  A61B5/04 ,  A61F13/02

CPC分类号： A61N1/30 ,  A61F13/00051 ,  A61F13/02 ,  A61F2013/00285 ,  A61F2013/00417 ,  A61F2013/00442 ,  A61F2013/00489 ,  A61F2013/00646 ,  A61F2013/00906 ,  A61F2013/00919 ,  A61F2013/00948 ,  A61F2013/00961

摘要： A transdermal medicament patch includes a biocompatible substrate having a therapeutic face on one side configured for disposition against the skin of a patient, a biocompatible adhesive on the therapeutic face, a planar medicament matrix covering a portion of the therapeutic face, and a release liner covering the portion of therapeutic that is not obscured by the medicament matrix. An aperture formed through the release sheet affords direct access by medicament to the entire surface of the medicament matrix opposite from the therapeutic face of the substrate. An active electrode positioned between the medicament matrix and the therapeutic face of the substrate includes an electrically conductive backing layer positioned against the therapeutic face of the substrate and a pH-control layer covering less than all of the side of the backing layer opposite from the therapeutic face of the substrate. One active electrode design criterion relates the relative size of the pH-control layer to the size of the backing layer; another relates the size of portion of the area of the backing layer that is free of the pH-control lawyer to the size of the pH-control layer. The pH-control layer is made of an electrically conductive material capable of moderating changes in the hydrogen-ion concentration in the medicament matrix during iontophoretic current flow. An electrical contact electrically coupled through the substrate to the backing layer includes a hollow, electrically conductive snap fitting having an open end and a cooperating stud that is inserted into the open end of the snap.

摘要翻译： 透皮药物贴片包括生物相容性基底，其具有在一侧上的治疗面，其配置用于处置患者的皮肤，治疗面上的生物相容性粘合剂，覆盖治疗面部分的平面药物基质和释放衬垫覆盖物 不被药物基质遮蔽的治疗部分。 通过剥离片形成的孔可以通过药物直接进入与基底的治疗面相反的药物基质的整个表面。 位于药物基质和基底的治疗面之间的有源电极包括抵靠基底的治疗面定位的导电背衬层和覆盖与治疗组相反的背衬层全部侧面的pH控制层 基材面。 一个活性电极设计标准将pH控制层的相对尺寸与背衬层的尺寸相关; 另一个涉及不含pH控制律师的背衬层的面积的部分尺寸与pH值控制层的尺寸。 pH控制层由能够调节离子电渗电流期间药物基质中氢离子浓度变化的导电材料制成。 通过基底电耦合到背衬层的电触点包括具有开口端的中空的导电卡扣配件，以及插入卡扣的开口端的协作钉。

公开(公告)号：US20080214985A1

公开(公告)日：2008-09-04

申请号：US12009409

申请日：2008-01-18

申请人： Jamal S. Yanaki

发明人： Jamal S. Yanaki

IPC分类号： A61N1/30

CPC分类号： A61N1/303 ,  A61K9/0009 ,  A61K9/7023

摘要： An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face. Each electrically conductively engages the skin, when the substrate is retained thereon. A power source carried on the substrate is electrically coupled between the medicament matrix and a programmed microprocessor also carried on the substrate. A substantially invariant voltage presented at an output contact of the microprocessor is applied during a predetermined therapy period across the skin between the medicament matrix and the return electrode, inducing transcutaneous migration of medicament into the skin at a substantially constant rate. A light-emitting diode carried on the substrate and coupled to the microprocessor communicates that the patch is operating.

摘要翻译： 活性透皮药物贴片包括具有可释放地保持抵抗患者皮肤的治疗面的平面基底。 易于被药物渗透的返回电极和药物基质固定在治疗面上的分离位置处。 当衬底保持在其上时，每个电导电地接合皮肤。 载体在基板上的电源电耦合在药物基质和也承载在基底上的编程微处理器之间。 在预定的治疗期间，在药物基质和返回电极之间的皮肤上施加呈现在微处理器的输出接触处的基本上不变的电压，从而以基本恒定的速率诱导药物经皮皮肤迁移到皮肤中。 携带在基板上并耦合到微处理器的发光二极管通信该补丁正在运行。

公开(公告)号：USD576282S1

公开(公告)日：2008-09-02

申请号：US29261600

申请日：2006-06-16

申请人： Jamal S. Yanaki

设计人： Jamal S. Yanaki

公开(公告)号：US20140316505A1

公开(公告)日：2014-10-23

申请号：US13868909

申请日：2013-04-23

申请人： Jamal S. Yanaki

发明人： Jamal S. Yanaki

IPC分类号： A61N1/04

CPC分类号： A61N1/0456 ,  A61N1/048 ,  A61N1/0496 ,  A61N1/36014 ,  A61N1/36025

摘要： The present invention is directed to signing up at a single site to receive both credit and business information, and the combining of personal credit information for an individual and business credit information of a business with which the individual is associated. For example, the invention can provide a website where a user can lrequest to view an individual's personal credit information and the business credit information of a business that the individual owns. In this manner, the user can quickly and easily obtain a more complete view of the financial status of an individual or a business in a single location.

摘要翻译： 本发明旨在在单个站点上注册以接收信用和商业信息，以及将个人的个人信用信息与个人所属的企业的商业信用信息的组合。 例如，本发明可以提供一个用户可以要求查看个人个人信用信息和个人拥有的企业的商业信用信息的网站。 以这种方式，用户可以快速且容易地获得在单个位置的个人或企业的财务状况的更完整的视图。

公开(公告)号：US08197844B2

公开(公告)日：2012-06-12

申请号：US11811241

申请日：2007-06-08

申请人： Jamal S. Yanaki

发明人： Jamal S. Yanaki

IPC分类号： A61F13/00 ,  A61F13/02 ,  A61B5/04

CPC分类号： A61N1/30 ,  A61F13/00051 ,  A61F13/02 ,  A61F2013/00285 ,  A61F2013/00417 ,  A61F2013/00442 ,  A61F2013/00489 ,  A61F2013/00646 ,  A61F2013/00906 ,  A61F2013/00919 ,  A61F2013/00948 ,  A61F2013/00961

摘要： A transdermal medicament patch includes a biocompatible substrate having a therapeutic face on one side configured for disposition against the skin of a patient, a biocompatible adhesive on the therapeutic face, a planar medicament matrix covering a portion of the therapeutic face, and a release liner covering the portion of therapeutic that is not obscured by the medicament matrix. An aperture formed through the release sheet affords direct access by medicament to the entire surface of the medicament matrix opposite from the therapeutic face of the substrate. An active electrode positioned between the medicament matrix and the therapeutic face of the substrate includes an electrically conductive backing layer positioned against the therapeutic face of the substrate and a pH-control layer covering less than all of the side of the backing layer opposite from the therapeutic face of the substrate. One active electrode design criterion relates the relative size of the pH-control layer to the size of the backing layer; another relates the size of portion of the area of the backing layer that is free of the pH-control lawyer to the size of the pH-control layer. The pH-control layer is made of an electrically conductive material capable of moderating changes in the hydrogen-ion concentration in the medicament matrix during iontophoretic current flow. An electrical contact electrically coupled through the substrate to the backing layer includes a hollow, electrically conductive snap fitting having an open end and a cooperating stud that is inserted into the open end of the snap.

摘要翻译： 透皮药物贴片包括生物相容性基底，其具有在一侧上的治疗面，其配置用于处置患者的皮肤，治疗面上的生物相容性粘合剂，覆盖治疗面部分的平面药物基质和释放衬垫覆盖物 不被药物基质遮蔽的治疗部分。 通过剥离片形成的孔可以通过药物直接进入与基底的治疗面相反的药物基质的整个表面。 位于药物基质和基底的治疗面之间的有源电极包括抵靠基底的治疗面定位的导电背衬层和覆盖与治疗组相反的背衬层全部侧面的pH控制层 基材面。 一个活性电极设计标准将pH控制层的相对尺寸与背衬层的尺寸相关; 另一个涉及不含pH控制律师的背衬层的面积的部分尺寸与pH值控制层的尺寸。 pH控制层由能够调节离子电渗电流期间药物基质中氢离子浓度变化的导电材料制成。 通过基底电耦合到背衬层的电触点包括具有开口端的中空的导电卡扣配件，以及插入卡扣的开口端的协作钉。

公开(公告)号：US20090186072A1

公开(公告)日：2009-07-23

申请号：US12009443

申请日：2008-01-18

申请人： Jamal S. Yanaki

发明人： Jamal S. Yanaki

IPC分类号： A61K9/70

CPC分类号： A61N1/303 ,  A61K9/7023 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/08 ,  A61N1/325

摘要： An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face and electrically conductively engage the skin. A detector monitors iontophoretic medicament migration into the skin. An integrator operating on the output of the detector produces a running cumulative total of the amount of medicament delivered during a plurality of temporally non-contiguous therapy subsessions. A circuit breaker terminates medicament migration, when the output of the integrator equals a predetermined medicament quantity. A timer active during medicament migration stimulates a driver to operate a light-emitting diode in a distinct delivery confirmation mode during each a sequence of non-overlapping predetermined therapy subsessions, respectively. A circuit board on the substrate in a compact, folded state bears interconnected electrical circuit components.

摘要翻译： 活性透皮药物贴片包括具有可释放地保持抵抗患者皮肤的治疗面的平面基底。 容易受药物渗透的返回电极和药物基质固定在治疗面上的分离位置处并导电地接合皮肤。 检测器监测离子电渗药物迁移到皮肤中。 在检测器的输出上操作的积分器产生在多个时间不连续的治疗子事件期间递送的药物的累计运行量。 当积分器的输出等于预定的药物量时，断路器终止药物迁移。 在药物迁移期间激活的计时器分别刺激驾驶员在每个不重叠的预定疗法子进程序列期间以不同的递送确认模式操作发光二极管。 紧凑的折叠状态的基板上的电路板具有互连的电路部件。

公开(公告)号：US09844669B2

公开(公告)日：2017-12-19

申请号：US12737327

申请日：2008-07-02

申请人： Jamal S. Yanaki

发明人： Jamal S. Yanaki

IPC分类号： A61N1/30 ,  A61N1/04

CPC分类号： A61N1/30 ,  A61N1/044 ,  A61N1/0448

摘要： Iontophoretically administering a cosmetic agent requires an active electrode and a return electrode secured to the skin (150). The active electrode includes a flexible biocompatible substrate (20, 170) having a therapeutic face (106, 206) configured for disposition toward the skin (150) and an exterior periphery (32, 182) shaped to facilitate conformance of the substrate (20, 170) to the skin (150) over an intended treatment region. A flexible electrically conductive layer (110, 210) is disposed on the therapeutic face (106, 206). The side of the conductive layer (110, 210) opposite from the substrate (20, 170) defines a driving face (120, 220) to which is affixed an electrically conductive adhesive matrix (82, 192) comprised of a material capable of repeatedly releasably securing the active electrode to the skin (150) through an applied solution (156, 158) of the cosmetic agent. A power source (76, 186) electrically connectable to the return electrode and to the conductive layer (110, 210) of the active electrode causes migration of the cosmetic agent away from the adhesive matrix (82, 192) into the skin (150).