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公开(公告)号:US20100173850A1
公开(公告)日:2010-07-08
申请号:US12514738
申请日:2007-11-15
申请人: Ralph Martins , Trevor Payne
发明人: Ralph Martins , Trevor Payne
CPC分类号: C07K7/06 , A61K38/00 , G01N2800/2821
摘要: A peptide sequence of the form: X(Lys,Arg)XXXXX(Arg,Lys)X, wherein Lys and Arg arc replaceable and X is preferably one or more of the following amino acids: hydrophobic amino acid residues (eg Pro, Leu. Met, Ile), basic amino acid residues or threonine; and wherein the sequence is capable of engaging Λβ and ameliorating its SOD activity and/or metal ion binding.
摘要翻译: 具有以下形式的肽序列:X(Lys,Arg)XXXXX(Arg,Lys)X,其中Lys和Arg可替代,X优选为以下氨基酸中的一个或多个:疏水性氨基酸残基(例如Pro,Leu。 Met,Ile),碱性氨基酸残基或苏氨酸; 并且其中所述序列能够接合Λ和bgr; 并改善其SOD活性和/或金属离子结合。