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1.发明公开公开(公告)号：US20240278040A1
公开(公告)日：2024-08-22
申请号：US18474135
申请日：2023-09-25
CPC分类号： A61N7/00 , A61B8/488 , A61N7/02 , A61B8/0808 , A61B8/4227 , A61B90/11 , A61N2007/0026 , A61N2007/0091
摘要： Ultrasonic energy is used for treating degenerative dementia. A focal point of an ultrasonic transducer beam is directed at a target area of the brain to promote removal of substances that accumulate in the interstitial pathways that are at least partially responsible for the degenerative dementia. In one example, the target area of the brain may comprise the hippocampus and the degenerative dementia may be Alzheimer's disease. The ultrasonic beam may stimulate brain tissue at a frequency that corresponds to a naturally occurring deep sleep burst frequency of neurons and subsequent astrocyte activation patterns that drive a convective process responsible for brain solute disposal. For example, the transducer may generate a burst frequency of between 1-4 hertz to stimulate deep sleep brain functions that help remove amyloid plaque.
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公开(公告)号：US20220283328A1
公开(公告)日：2022-09-08
申请号：US17686649
申请日：2022-03-04
摘要： Calibration or quality assurance devices and methods that ensure proper ultrasound exposure. An apparatus for calibrating an ultrasound transducer is provided. The apparatus includes a hydrophone assembly having a layer containing a solid material and a hydrophone element embedded in the solid material of the layer. A method of calibrating a therapeutic ultrasound system including an ultrasound transducer and system electronics is also provided. The method may include connecting the ultrasound transducer to an electronics module, separately connecting the system electronics to the electronics module, driving the ultrasound transducer at a given frequency to emit an ultrasound beam, sensing the ultrasound beam with a hydrophone element, and measuring a signal that is output from the hydrophone element.
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公开(公告)号：USD946153S1
公开(公告)日：2022-03-15
申请号：US29735396
申请日：2020-05-20
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4.发明授权公开(公告)号：US10974078B2
公开(公告)日：2021-04-13
申请号：US15842771
申请日：2017-12-14
摘要： Ultrasonic energy is used for treating degenerative dementia. A focal point of an ultrasonic transducer beam is directed at a target area of the brain to promote removal of substances that accumulate in the interstitial pathways that are at least partially responsible for the degenerative dementia. In one example, the target area of the brain may comprise the hippocampus and the degenerative dementia may be Alzheimer's disease. The ultrasonic beam may stimulate brain tissue at a frequency that corresponds to a naturally occurring deep sleep burst frequency of neurons and subsequent astrocyte activation patterns that drive a convective process responsible for brain solute disposal. For example, the transducer may generate a burst frequency of between 1-4 hertz to stimulate deep sleep brain functions that help remove amyloid plaque.
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公开(公告)号：US09630029B2
公开(公告)日：2017-04-25
申请号：US14478323
申请日：2014-09-05
发明人： Walter William Wurster , Michael Allen Gustafson , Elaine Patrice Pelletier , Richard Alan Waltz
CPC分类号： A61N7/02 , A61B8/4227 , A61B90/11 , A61N7/00 , A61N2007/0091
摘要： A focused ultrasonic transducer navigation system attaches to a patient and includes a housing that contains an ultrasonic device. An alignment system moves the housing, and moves the ultrasonic device within the housing, so a focal point of ultrasonic energy from the ultrasonic device is aligned in x, y, and z planes with a target location in the patient. The alignment system realigns the focal point of the ultrasonic device with the same patient target location over multiple therapy sessions eliminating repeated use of an MRI system for repeatedly realigning the ultrasonic device.
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公开(公告)号：US08086296B2
公开(公告)日：2011-12-27
申请号：US11895687
申请日：2007-08-27
申请人： Alexander Bystritsky
发明人： Alexander Bystritsky
IPC分类号： A61B5/055
CPC分类号： A61N7/02 , A61B2090/374 , A61N2007/0078
摘要： Disclosed herein are methods for modifying electrical currents in brain circuits through the simultaneous use of focused ultrasound pulse (FUP) and an existing brain-imaging system, such as a functional magnetic resonance imaging (fMRI) system. The methods are used for research, treatment and diagnosis of psychiatric, neurological, and neuroendocrine disorders whose biological mechanisms include brain circuits. The methods include the simultaneous steps of applying FUP to a live neuronal circuit within a brain and monitoring a brain image produced by a brain imaging system during the application of FUP.
摘要翻译： 本文公开了通过同时使用聚焦超声脉冲（FUP）和现有脑成像系统（诸如功能磁共振成像（fMRI））系统来修改脑电路中的电流的方法。 这些方法用于精神，神经和神经内分泌障碍的研究，治疗和诊断，其生物学机制包括脑电路。 所述方法包括将FUP应用于脑内活体神经元电路并监测在应用FUP期间由脑成像系统产生的脑图像的同步步骤。
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7.发明申请公开(公告)号：US20220314032A1
公开(公告)日：2022-10-06
申请号：US17709905
申请日：2022-03-31
摘要： Ultrasound treatment of neurological conditions with energy levels that do not cause damage such as heating or cavitation. A method includes detecting a plurality of Doppler signals from a plurality of arteries near a brain structure, aligning an ultrasound transducer with the brain structure based on the plurality of Doppler signals, and applying ultrasound waves from the ultrasound transducer to the brain structure.
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公开(公告)号：US09061133B2
公开(公告)日：2015-06-23
申请号：US13728392
申请日：2012-12-27
发明人： Walter William Wurster , Michael Allen Gustafson , Elaine Patrice Pelletier , Richard Alan Waltz
CPC分类号： A61N7/02 , A61B8/4227 , A61B90/11 , A61N7/00 , A61N2007/0091
摘要： A focused ultrasonic transducer navigation system attaches to a patient and includes a housing that contains an ultrasonic device. An alignment system moves the housing, and moves the ultrasonic device within the housing, so a focal point of ultrasonic energy from the ultrasonic device is aligned in x, y, and z planes with a target location in the patient. The alignment system realigns the focal point of the ultrasonic device with the same patient target location over multiple therapy sessions eliminating repeated use of an MRI system for repeatedly realigning the ultrasonic device.
摘要翻译： 聚焦的超声波换能器导航系统附接到患者并且包括容纳超声装置的壳体。 对准系统移动壳体并使超声波装置移动到壳体内，使得来自超声波装置的超声波能量焦点在x，y和z平面上与患者中的目标位置对齐。 对准系统通过多个治疗会话使超声波装置的焦点与相同的患者目标位置重新对准，从而消除重复使用MRI系统以重复重新调整超声波装置。
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公开(公告)号：US20140378874A1
公开(公告)日：2014-12-25
申请号：US14478323
申请日：2014-09-05
发明人： Walter William Wurster , Michael Allen Gustafson , Elaine Patrice Pelletier , Richard Alan Waltz
CPC分类号： A61N7/02 , A61B8/4227 , A61B90/11 , A61N7/00 , A61N2007/0091
摘要： A focused ultrasonic transducer navigation system attaches to a patient and includes a housing that contains an ultrasonic device. An alignment system moves the housing, and moves the ultrasonic device within the housing, so a focal point of ultrasonic energy from the ultrasonic device is aligned in x, y, and z planes with a target location in the patient. The alignment system realigns the focal point of the ultrasonic device with the same patient target location over multiple therapy sessions eliminating repeated use of an MRI system for repeatedly realigning the ultrasonic device.
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10.发明授权公开(公告)号：US11766576B2
公开(公告)日：2023-09-26
申请号：US17193087
申请日：2021-03-05
CPC分类号： A61N7/00 , A61B8/488 , A61N7/02 , A61B8/0808 , A61B8/4227 , A61B90/11 , A61N2007/0026 , A61N2007/0091
摘要： Ultrasonic energy is used for treating degenerative dementia. A focal point of an ultrasonic transducer beam is directed at a target area of the brain to promote removal of substances that accumulate in the interstitial pathways that are at least partially responsible for the degenerative dementia. In one example, the target area of the brain may comprise the hippocampus and the degenerative dementia may be Alzheimer's disease. The ultrasonic beam may stimulate brain tissue at a frequency that corresponds to a naturally occurring deep sleep burst frequency of neurons and subsequent astrocyte activation patterns that drive a convective process responsible for brain solute disposal. For example, the transducer may generate a burst frequency of between 1-4 hertz to stimulate deep sleep brain functions that help remove amyloid plaque.
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