公开(公告)号：US20070232996A1

公开(公告)日：2007-10-04

申请号：US11587693

申请日：2005-04-28

Applicant: Erik Andersen

Inventor： Erik Andersen

IPC: A61M29/00

CPC classification number: A61L31/16 ,  A61F2/958 ,  A61F2250/0067 ,  A61L2300/114 ,  A61L2300/604 ,  A61L2400/12 ,  A61M25/1027 ,  A61M25/1038 ,  A61M25/104 ,  A61M2025/1004 ,  A61M2025/1031 ,  A61M2025/1075

Abstract: An expandable balloon for use in angioplasty procedures comprises a balloon having an outer surface layer, the outer surface layer being made from electrospun nanofibers and incorporating at least one pharmaceutically active substance, such as nitric oxide (NO). The outer surface layer may be formed on a separate flexible tubular member or sock, which is slipped over the balloon. A method of treating cell disorders in tubular structures of a living being comprises the steps of placing a coated balloon at a treatment site within the tubular structures, expanding the balloon at the treatment site, and releasing the pharmaceutically active substance at the treatment site. Optionally, a stent may be crimped onto the balloon prior to insertion of the balloon and scent into the tubular structures of the living being.

Abstract translation: 用于血管成形术程序的可膨胀气囊包括具有外表面层的球囊，外表面层由静电纺丝纳米纤维制成并且并入至少一种药物活性物质，例如一氧化氮（NO）。 外表面层可以形成在单独的柔性管状构件或袜子上，该弹性管状构件或袜子滑过气球。 一种治疗生物体管状结构中的细胞病症的方法包括以下步骤：将涂覆的球囊放置在管状结构内的治疗部位，使治疗部位膨胀，并在治疗部位释放药物活性物质。 可选地，在插入气囊和气味进入生命体的管状结构之前，可以将支架卷曲到球囊上。

公开(公告)号：US20060079469A1

公开(公告)日：2006-04-13

申请号：US10493486

申请日：2002-10-25

Applicant: Erik Anderson ,  Trung Le Doan ,  Laurent Lamidey

Inventor： Erik Anderson ,  Trung Le Doan ,  Laurent Lamidey

IPC: A61K48/00

CPC classification number: A61L31/16

Abstract: An anti-restenosis agent comprises a phosphorothioate-modified oligonucleotide includes at least on hairpin loop and a TG sequence. The hairpin loop preferably has the sequence CAG CGA AGC. Especially preferred oligonucleotides are ones which include a sequence selected from TGGGG TGGGG T GGGGT GGGGT CAG CGA AGC (SEQ ED NO: 4) and TTGGG TTGGG T GGGTT GGGTT CAG CGA AGC (SEQ TD NO: 6). The anti-restenosis agent may be used as or in a coating on a device for implantation into the body, for instance a stent.

Abstract translation: 抗再狭窄剂包含至少在发夹环和TG序列上的硫代磷酸酯修饰的寡核苷酸。 发夹环优选具有序列CAG CGA AGC。 特别优选的寡核苷酸是包括选自TGGGG TGGGG T GGGGT GGGGT CAG CGA AGC（SEQ ID NO：4）和TTGGG TTGGG T GGGTT GGGTT CAG CGA AGC（SEQ ID NO：6）的序列的寡核苷酸。 抗再狭窄剂可以用作植入装置中用于植入体内的涂层，例如支架。

公开(公告)号：US20060293743A1

公开(公告)日：2006-12-28

申请号：US10531327

申请日：2003-10-14

Applicant: Erik Andersen ,  Ning Wen

Inventor： Erik Andersen ,  Ning Wen

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61F2/91 ,  A61F2/915

Abstract: A stent assembly comprises an expandable tubular stent (21), an external surface of which is provided with a fabric (5) which may constitute a reservoir to hold drugs to be released in the intravascular system of a living. The fabric (5) may be made from a filamentary material, such as multifilament yarn (6). Electrospinning of nanofibers of, e.g., polymer may be employed for manufacturing the fabric. The stent may comprise an assembly of radially expandable, tubular elements (1) aligned along a common longitudinal axis and successively joined together in pairs by respective sets of linking members (4), e.g. forming a zigzag corrugation. The stent may be crimped onto a balloon.

Abstract translation: 支架组件包括可扩张的管状支架（21），其外表面设置有织物（5），所述织物可以构成储存器以容纳待释放的活体血管内系统中的药物。 织物（5）可以由丝状材料制成，例如复丝纱线（6）。 例如聚合物的纳米纤维的静电纺丝可用于制造织物。 支架可以包括沿着共同的纵向轴线对准的可径向扩张的管状元件（1）的组件，并且通过相应的一组连接构件（4）成对连续地连接在一起。 形成锯齿形波纹。 支架可以卷曲到气球上。