公开(公告)号：US20060079469A1

公开(公告)日：2006-04-13

申请号：US10493486

申请日：2002-10-25

Applicant: Erik Anderson ,  Trung Le Doan ,  Laurent Lamidey

Inventor： Erik Anderson ,  Trung Le Doan ,  Laurent Lamidey

IPC: A61K48/00

CPC classification number: A61L31/16

Abstract: An anti-restenosis agent comprises a phosphorothioate-modified oligonucleotide includes at least on hairpin loop and a TG sequence. The hairpin loop preferably has the sequence CAG CGA AGC. Especially preferred oligonucleotides are ones which include a sequence selected from TGGGG TGGGG T GGGGT GGGGT CAG CGA AGC (SEQ ED NO: 4) and TTGGG TTGGG T GGGTT GGGTT CAG CGA AGC (SEQ TD NO: 6). The anti-restenosis agent may be used as or in a coating on a device for implantation into the body, for instance a stent.

Abstract translation: 抗再狭窄剂包含至少在发夹环和TG序列上的硫代磷酸酯修饰的寡核苷酸。 发夹环优选具有序列CAG CGA AGC。 特别优选的寡核苷酸是包括选自TGGGG TGGGG T GGGGT GGGGT CAG CGA AGC（SEQ ID NO：4）和TTGGG TTGGG T GGGTT GGGTT CAG CGA AGC（SEQ ID NO：6）的序列的寡核苷酸。 抗再狭窄剂可以用作植入装置中用于植入体内的涂层，例如支架。