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1.发明授权公开(公告)号：US07932024B2
公开(公告)日：2011-04-26
申请号：US10590768
申请日：2005-02-25
CPC分类号： C12Q1/24 , C12Q1/04 , G01N2001/021
摘要： The present invention relates to a method, a chip, a device, and a system for collection of biological particles. The method makes use of electrostatic attraction of biological particles to charged electrodes and preferably operates with gaseous samples. The method, chip, device, and system are e.g. useful for collecting pathogenic biological particles, such as bacterial spores and vira, from air samples and allow for subsequent analysis of the collected biological particles.
摘要翻译： 本发明涉及用于收集生物颗粒的方法，芯片，装置和系统。 该方法利用生物粒子对带电电极的静电吸引，优选与气态样品一起操作。 方法，芯片，装置和系统是例如。 可用于从空气样品中收集致病生物颗粒，如细菌孢子和病毒，并允许随后分析所收集的生物颗粒。
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公开(公告)号：US07985540B2
公开(公告)日：2011-07-26
申请号：US10590630
申请日：2005-02-25
CPC分类号： C12N15/1003 , C12N1/066 , C12N13/00
摘要： The present invention relates to a method, a chip, a device and a system for extraction of biological material form biological cells. The invention involves exposing the biological particles to an alternating electric field in a sample chamber and may also involve subsequent analysis of the biological material after the extraction.
摘要翻译： 本发明涉及用于从生物细胞中提取生物材料的方法，芯片，装置和系统。 本发明涉及将生物颗粒暴露于样品室中的交变电场，并且还可以涉及在提取之后对生物材料的后续分析。
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3.发明授权Apparatus and sensing devices for measuring fluorescence lifetimes of fluorescence sensors 失效用于测量荧光传感器荧光寿命的装置和感测装置公开(公告)号：US07289204B2
公开(公告)日：2007-10-30
申请号：US10476425
申请日：2002-05-02
申请人： Hans Ole Nielsen , Jan H. Hansen , Kim P. Hansen
发明人： Hans Ole Nielsen , Jan H. Hansen , Kim P. Hansen
IPC分类号： G01J3/30
CPC分类号： G01N21/6408 , G01N21/7703 , G01N2021/6419 , G01N2021/6421 , G01N2021/6434 , G01N2021/6484 , G01N2201/086
摘要： An apparatus and devices for measuring fluorescence lifetimes of fluorescence sensors for one or more analytes, the apparatus comprising (c) one or more reference systems (3,6,7), said reference systems each comprising one or more reference light sources (3) and being adapted to receive one or more excitation signals (1a), to produce reference optical signals (6b) in response thereto, and to produce one or more electrical reference output signals (7b) in response to one or more excitation signals (1a); and (d) or more phase detectors (10), said phase detections being adapted to detect one or more delays of said one or more electrical output signals of said one or more fluorescence sensor systems and said one or more reference systems, and to produce one or more phase output signals; and a method of measuring concentration of one or more analytes using such apparatus and/or devices.
摘要翻译： 一种用于测量一种或多种分析物的荧光传感器的荧光寿命的装置和装置，所述装置包括（c）一个或多个参考系统（3,6,7），所述参考系统各自包括一个或多个参考光源（3） 并且适于接收一个或多个激励信号（1a）以响应于此产生参考光信号（6b），并响应于一个或多个激励信号产生一个或多个电参考输出信号（7b） （1 a）; 和（d）或更多相位检测器（10），所述相位检测器适于检测所述一个或多个荧光传感器系统和所述一个或多个参考系统的所述一个或多个电输出信号的一个或多个延迟，并且产生 一个或多个相位输出信号; 以及使用这种装置和/或装置测量一种或多种分析物的浓度的方法。
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公开(公告)号：US09176057B2
公开(公告)日：2015-11-03
申请号：US13576044
申请日：2011-02-04
IPC分类号： G01N21/55
CPC分类号： G01N21/55 , G01N2021/551
摘要： An apparatus for measuring the retroreflectivity of a surface. The apparatus comprises a light source for illuminating an area of said surface at an incident angle relative to the surface; a detector for detecting light reflected back from the surface at an observation angle relative to the surface; a signal processing unit adapted to receive a detector signal from the detector and to determine, from at least the received detector signal, a measure of retro reflectivity of the surface; a range finder for measuring a distance between the apparatus and the illuminated area. The signal processing unit is further adapted to adjust the measure of retroreflectivity responsive to the measured distance.
摘要翻译： 用于测量表面的后向反射率的装置。 该装置包括用于以相对于该表面入射的角度照射所述表面的区域的光源; 用于检测从表面以相对于表面观察角度反射回的光的检测器; 信号处理单元，适于从所述检测器接收检测器信号，并且从至少所接收的检测器信号确定所述表面的复现反射率的量度; 用于测量设备和照明区域之间的距离的测距仪。 信号处理单元还适于响应于测量的距离来调节后向反射率的测量。
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5.发明授权Method, chip, device and integrated system for detection biological particles 有权检测生物粒子的方法，芯片，器件和集成系统公开(公告)号：US07892794B2
公开(公告)日：2011-02-22
申请号：US10590632
申请日：2005-02-25
CPC分类号： C12Q1/04 , C12Q1/24 , G01N2001/021
摘要： The present invention relates to a method, a chip, a device, and a system for detection of biological particles. The method of the invention typically comprises collecting the biological particles from a gaseous sample, contacting the biological particles with a first liquid reagent, extracting biological material from the collected biological particles, and analyzing the biological material for the presence of a target nucleic acid sequence.
摘要翻译： 本发明涉及一种检测生物颗粒的方法，芯片，装置和系统。 本发明的方法通常包括从气态样品中收集生物颗粒，使生物颗粒与第一液体试剂接触，从收集的生物颗粒中提取生物材料，并分析生物材料以存在靶核酸序列。
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公开(公告)号：US07298487B2
公开(公告)日：2007-11-20
申请号：US10511686
申请日：2003-04-02
CPC分类号： G01N21/4738 , G01N21/55
摘要： A method and apparatus for measuring light reflections of an object, comprising a light-source illumination-observation assembly, the assembly comprising: (A) an illumination unit comprising an illumination light source and illumination aperture stop being arranged to provide a confined luminous field, an illumination field stop (307) adapted to provide an illumination beam (305) of light from said confined luminous field, an collimating optical element (309) adapted to collimate said illumination beam and to provide an illumination field (313) on an object; (B) an observation unit comprising: at least one observation field stop adapted to provide an observation beam (306) comprising a ray boundary, at least one focusing optical element (309) adapted to focus said observation beam, an observation light receiver; and (C) at least one common optical element (309) arranged so that said illumination beam and said observation beam form an overlap therein; and (D) a unit separation stop (310) adapted to stop light from said illumination unit in reaching said observation light receiver of said observation unit; wherein said at least one observation field stops (308, 310, 311) comprises at least one limiting field stop (310) adapted to limit said ray boundary of said observation beam and to maintain said overlap of said illumination beam and said observation beam; a diffuser light-source assembly; and use thereof.
摘要翻译： 一种用于测量物体的光反射的方法和装置，包括光源照明观察组件，该组件包括：（A）包括照明光源和照明孔径光阑的照明单元，其被布置成提供有限的发光场， 适于提供来自所述受限发光场的光的照明光束（305）的照明场停止器（307），适于准直所述照明光束并且在物体上提供照明场（313）的准直光学元件（309） （B）观察单元，包括：适于提供包括射线边界的观察光束（306）的至少一个观察场停止件，适于聚焦所述观察光束的至少一个聚焦光学元件（309），观察光接收器; 和（C）至少一个共同的光学元件（309），其布置成使得所述照明光束和所述观察光束在其中形成重叠; 和（D）适于在到达所述观察单元的所述观察光接收器时停止来自所述照明单元的光的单元分离停止件（310） 其中所述至少一个观察场停止（308,310,311）包括适于限制所述观察光束的所述光线边界并保持所述照明光束和所述观察光束的所述重叠的至少一个限制场停止（310） 扩散器光源组件; 及其用途。
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