公开(公告)号：US10369051B2

公开(公告)日：2019-08-06

申请号：US14403155

申请日：2013-05-23

申请人： Ellex R&D Pty Ltd

发明人： Malcolm Plunkett ,  Wei Xia

IPC分类号： A61F9/008 ,  G02B26/08 ,  F21V14/04 ,  G02B7/182 ,  G02B27/14

摘要： A mirror for an ophthalmic laser treatment device that is movable on an axis from a position in a treatment laser beam path to a position out of the treatment laser beam path. The mirror reflects light from a light source into the eye of a patient. The mirror is biased towards a position in the path and is moved out of the path by an actuator just long enough for the laser treatment to be applied and without noticeable interruption to viewing by a user.

公开(公告)号：US08562595B2

公开(公告)日：2013-10-22

申请号：US12446677

申请日：2007-10-25

申请人： Malcolm Plunkett ,  Aly Hussain ,  John Marshall

发明人： Malcolm Plunkett ,  Aly Hussain ,  John Marshall

IPC分类号： A61B18/18

CPC分类号： A61F9/008 ,  A61F9/00821 ,  A61F2009/00863

摘要： A method of retinal regeneration which improves retinal function by reversal of the degradation of the transport properties of Bruch's membrane. The method involves irradiation through the cornea of the eye to the retinal pigmented epithelium by a laser pulse or sequence of laser pulses having a pulse duration in the range of 10 ps to 20 μs and at a wavelength in the range of about 500 nm to 900 nm. The method applies a radiant exposure which results in the damaging or altering of the retinal pigmented epithelium cells in such a manner as to trigger cellular responses which improve the hydraulic conductivity of Bruch's membrane without causing irreversible damage to adjacent retinal structures and layers.

摘要翻译： 视网膜再生的方法通过逆转Bruch膜转运性能的降低来改善视网膜功能。 该方法包括通过激光脉冲或脉冲序列的脉冲持续时间在10ps至20微米的范围内并且在约500nm至900nm的波长范围内通过眼睛的角膜照射到视网膜色素上皮 nm。 该方法应用辐射暴露，其导致视网膜色素上皮细胞的损伤或改变，以触发细胞反应，其改善Bruch膜的水力传导性，而不会对相邻的视网膜结构和层造成不可逆的损伤。

公开(公告)号：US20100152716A1

公开(公告)日：2010-06-17

申请号：US12600393

申请日：2008-05-29

申请人： Victor Previn ,  Malcolm Plunkett

发明人： Victor Previn ,  Malcolm Plunkett

IPC分类号： A61F9/008 ,  A61B18/20

CPC分类号： A61F9/008 ,  A61F9/00814 ,  A61F9/00821 ,  A61F2009/00863

摘要： A laser treatment device for use in retinal regeneration. The laser treatment device includes a laser module that delivers a pulse or sequence of pulses having a pulse duration in the range of 50 ps to 500 ns, a wavelength in the range 500 nm to 900 nm, and a pulse energy in the range 100 μJ to 10 mJ. The laser treatment device also includes a uniform irradiance module that modifies an output beam profile of the laser module to produce a uniform treatment effect and a beam delivery and viewing module that delivers the laser pulse or pulses to the retina with a radiant exposure in the range of 8 mJ/cm2 to 8000 mJ/cm2 per pulse.

摘要翻译： 一种用于视网膜再生的激光治疗装置。 该激光治疗装置包括：激光器模块，其传送脉冲或脉冲序列，其脉冲持续时间范围为50ps至500ns，波长范围为500nm至900nm，脉冲能量为100μJ 至10 mJ 激光治疗装置还包括均匀的辐照度模块，其修改激光模块的输出光束轮廓以产生均匀的治疗效果，以及光束传递和观察模块，其将激光脉冲或脉冲传送到视网膜，辐射曝光范围 每脉冲8mJ / cm 2至8000mJ / cm 2。

公开(公告)号：US20190209371A1

公开(公告)日：2019-07-11

申请号：US16275249

申请日：2019-02-13

申请人： ELLEX R&D PTY LTD

发明人： Malcolm PLUNKETT ,  Wei XIA

IPC分类号： A61F9/008 ,  G02B26/08 ,  G02B7/182 ,  G02B27/14 ,  F21V14/04

CPC分类号： A61F9/008 ,  F21V14/04 ,  G02B7/1827 ,  G02B26/0816 ,  G02B27/14

摘要： A mirror for an ophthalmic laser treatment device that is movable on an axis from a position in a treatment laser beam path to a position out of the treatment laser beam path. The mirror reflects light from a light source into the eye of a patient. The mirror is biased towards a position in the path and is moved out of the path by an actuator just long enough for the laser treatment to be applied and without noticeable interruption to viewing by a user.

公开(公告)号：US08496649B2

公开(公告)日：2013-07-30

申请号：US12600393

申请日：2008-05-29

申请人： Victor Previn ,  Malcolm Plunkett

发明人： Victor Previn ,  Malcolm Plunkett

IPC分类号： A61B18/18 ,  A61F9/008

CPC分类号： A61F9/008 ,  A61F9/00814 ,  A61F9/00821 ,  A61F2009/00863

摘要： A laser treatment device for use in retinal regeneration. The laser treatment device includes a laser module that delivers a pulse or sequence of pulses having a pulse duration in the range of 50 ps to 500 ns, a wavelength in the range 500 nm to 900 nm, and a pulse energy in the range 100 μJ to 10 mJ. The laser treatment device also includes a uniform irradiance module that modifies an output beam profile of the laser module to produce a uniform treatment effect and a beam delivery and viewing module that delivers the laser pulse or pulses to the retina with a radiant exposure in the range of 8 mJ/cm2 to 8000 mJ/cm2 per pulse.

摘要翻译： 一种用于视网膜再生的激光治疗装置。 激光治疗装置包括：激光器模块，其输送具有50ps至500ns范围内的脉冲持续时间的脉冲或脉冲序列，波长范围为500nm至900nm，脉冲能量范围为100μJ 至10 mJ 激光治疗装置还包括均匀的辐照度模块，其修改激光模块的输出光束轮廓以产生均匀的治疗效果，以及光束传递和观察模块，其将激光脉冲或脉冲传送到视网膜，辐射曝光范围 每脉冲8mJ / cm 2至8000mJ / cm 2。

公开(公告)号：US20100049173A1

公开(公告)日：2010-02-25

申请号：US12446677

申请日：2007-10-25

申请人： Malcolm Plunkett ,  Aly Hussain ,  John Marshall

发明人： Malcolm Plunkett ,  Aly Hussain ,  John Marshall

IPC分类号： A61F9/008 ,  A61B18/20

CPC分类号： A61F9/008 ,  A61F9/00821 ,  A61F2009/00863

摘要： A method of retinal regeneration which improves retinal function by reversal of the degradation of the transport properties of Bruch's membrane. The method involves irradiation through the cornea of the eye to the retinal pigmented epithelium by a laser pulse or sequence of laser pulses having a pulse duration in the range of 10 ps to 20 μs and at a wavelength in the range of about 500 nm to 900 nm. The method applies a radiant exposure which results in the damaging or altering of the retinal pigmented epithelium cells in such a manner as to trigger cellular responses which improve the hydraulic conductivity of Bruch's membrane without causing irreversible damage to adjacent retinal structures and layers.

摘要翻译： 视网膜再生的方法通过逆转Bruch膜转运性能的降低来改善视网膜功能。 该方法包括通过激光脉冲或脉冲持续时间在10ps至20μs范围内并且在约500nm至900nm范围内的波长的激光脉冲或序列来将眼睛的角膜照射到视网膜色素上皮 nm。 该方法应用辐射暴露，其导致视网膜色素上皮细胞的损伤或改变，以触发细胞反应，其改善Bruch膜的水力传导性，而不会对相邻的视网膜结构和层造成不可逆的损伤。