公开(公告)号：US20100049173A1

公开(公告)日：2010-02-25

申请号：US12446677

申请日：2007-10-25

申请人： Malcolm Plunkett ,  Aly Hussain ,  John Marshall

发明人： Malcolm Plunkett ,  Aly Hussain ,  John Marshall

IPC分类号： A61F9/008 ,  A61B18/20

CPC分类号： A61F9/008 ,  A61F9/00821 ,  A61F2009/00863

摘要： A method of retinal regeneration which improves retinal function by reversal of the degradation of the transport properties of Bruch's membrane. The method involves irradiation through the cornea of the eye to the retinal pigmented epithelium by a laser pulse or sequence of laser pulses having a pulse duration in the range of 10 ps to 20 μs and at a wavelength in the range of about 500 nm to 900 nm. The method applies a radiant exposure which results in the damaging or altering of the retinal pigmented epithelium cells in such a manner as to trigger cellular responses which improve the hydraulic conductivity of Bruch's membrane without causing irreversible damage to adjacent retinal structures and layers.

摘要翻译： 视网膜再生的方法通过逆转Bruch膜转运性能的降低来改善视网膜功能。 该方法包括通过激光脉冲或脉冲持续时间在10ps至20μs范围内并且在约500nm至900nm范围内的波长的激光脉冲或序列来将眼睛的角膜照射到视网膜色素上皮 nm。 该方法应用辐射暴露，其导致视网膜色素上皮细胞的损伤或改变，以触发细胞反应，其改善Bruch膜的水力传导性，而不会对相邻的视网膜结构和层造成不可逆的损伤。

公开(公告)号：US08562595B2

公开(公告)日：2013-10-22

申请号：US12446677

申请日：2007-10-25

申请人： Malcolm Plunkett ,  Aly Hussain ,  John Marshall

发明人： Malcolm Plunkett ,  Aly Hussain ,  John Marshall

IPC分类号： A61B18/18

CPC分类号： A61F9/008 ,  A61F9/00821 ,  A61F2009/00863

摘要： A method of retinal regeneration which improves retinal function by reversal of the degradation of the transport properties of Bruch's membrane. The method involves irradiation through the cornea of the eye to the retinal pigmented epithelium by a laser pulse or sequence of laser pulses having a pulse duration in the range of 10 ps to 20 μs and at a wavelength in the range of about 500 nm to 900 nm. The method applies a radiant exposure which results in the damaging or altering of the retinal pigmented epithelium cells in such a manner as to trigger cellular responses which improve the hydraulic conductivity of Bruch's membrane without causing irreversible damage to adjacent retinal structures and layers.

摘要翻译： 视网膜再生的方法通过逆转Bruch膜转运性能的降低来改善视网膜功能。 该方法包括通过激光脉冲或脉冲序列的脉冲持续时间在10ps至20微米的范围内并且在约500nm至900nm的波长范围内通过眼睛的角膜照射到视网膜色素上皮 nm。 该方法应用辐射暴露，其导致视网膜色素上皮细胞的损伤或改变，以触发细胞反应，其改善Bruch膜的水力传导性，而不会对相邻的视网膜结构和层造成不可逆的损伤。