公开(公告)号：US20130243891A1

公开(公告)日：2013-09-19

申请号：US13886610

申请日：2013-05-03

申请人： Jacqueline Shan ,  Sandra Miller

发明人： Jacqueline Shan ,  Sandra Miller

IPC分类号： A61K36/258

CPC分类号： A61K36/258 ,  A61K31/715

摘要： The invention is directed to a method of treating hematological malignancies by administering to the subject ginseng fractions from North American ginseng (Panax quinquefolium). The present invention can be used to activate the proliferation of hemopoietic cells in a patient in need of treatment, or as a therapeutic targeted at conditions characterized by hematological malignancy, such as an abnormal proliferation of blood cells, lymphocytes, multiple myeloma, etc. The invention also includes a method of treating leukemia by activating the proliferation of natural killer (NK) cells and monocytes in the bone marrow and the spleen of the patient by administering at least one ginseng fraction selected from the group consisting of CVT-E002, PQ.sub.2, PQ.sub.223 and purified fractions from CVT-E002, PQ.sub.2 and PQ.sub.223. The present invention may be used to treat the hematological malignancy or as a supplement for patients undergoing chemotherapy or radiation therapy.

摘要翻译： 本发明涉及通过对来自北美人参（Panax quinquefolium）的受试者的人参成分施用治疗血液恶性肿瘤的方法。 本发明可用于激活需要治疗的患者中造血细胞的增殖，或用作以血液恶性肿瘤为特征的病症，如血细胞，淋巴细胞，多发性骨髓瘤等的异常增殖。 本发明还包括通过施用至少一种选自CVT-E002，PQ的人参组分来激活骨髓和患者的脾脏中的天然杀伤（NK）细胞和单核细胞的增殖来治疗白血病的方法。 sub.2，PQ2.23和来自CVT-E002，PQ2和PQ2.23的纯化级分。 本发明可用于治疗血液恶性肿瘤或作为进行化疗或放射治疗的患者的补充。

公开(公告)号：US08039027B1

公开(公告)日：2011-10-18

申请号：US11659537

申请日：2000-02-25

申请人： Larry Guilbert ,  Jacqueline Shan ,  Joanne Totosy De Zepetnek

发明人： Larry Guilbert ,  Jacqueline Shan ,  Joanne Totosy De Zepetnek

IPC分类号： A61K36/894 ,  A61K36/00

CPC分类号： A61K36/258 ,  A61K2300/00

摘要： Use of ginseng extracts designated CVT-E002, PQ2, PQ2A, PQ2B, PQ2C, PQ2D, and PQ223 in the preparation of a pharmaceutical composition suitable for treating an autoimmune disease.

摘要翻译： 使用指定为CVT-E002，PQ2，PQ2A，PQ2B，PQ2C，PQ2D和PQ223的人参提取物制备适于治疗自身免疫性疾病的药物组合物。

公开(公告)号：US07906150B2

公开(公告)日：2011-03-15

申请号：US11754524

申请日：2007-05-29

申请人： Peter K. T. Pang ,  Jacqueline J. Shan ,  Kam Chiu

发明人： Peter K. T. Pang ,  Jacqueline J. Shan ,  Kam Chiu

IPC分类号： A61K35/12 ,  A61K35/34 ,  A61K38/00 ,  C07K14/00 ,  C07K17/00

CPC分类号： A61K35/32 ,  A61K35/60 ,  A61K38/00 ,  C07K7/64 ,  C07K14/46 ,  C07K14/461

摘要： Shark cartilage extract has been shown to be an antagonist of parathyroid hypertensive factor (PHF). In view of this, shark cartilage extract can be used to treat conditions related to excessive PHF activity. Such diseases include hypertension and some other diseases related to intracellular calcium elevation. Methods for producing the shark cartilage extract and methods for administering the extract are disclosed.

摘要翻译： 鲨鱼软骨提取物已被证明是甲状旁腺高血压因子（PHF）的拮抗剂。 鉴于此，鲨鱼软骨提取物可用于治疗与过量PHF活性有关的病症。 这些疾病包括与细胞内钙升高相关的高血压和一些其它疾病。 公开了生产鲨鱼软骨提取物的方法和施用提取物的方法。

公开(公告)号：US20100278945A1

公开(公告)日：2010-11-04

申请号：US12839386

申请日：2010-07-19

申请人： Jacqueline J. Shan ,  Peter K. T. Pang ,  Buhan Huang ,  Lei Ling

发明人： Jacqueline J. Shan ,  Peter K. T. Pang ,  Buhan Huang ,  Lei Ling

IPC分类号： A61K36/258 ,  A61P31/16 ,  A61P37/08 ,  A61P37/00 ,  A61P35/00 ,  C12N5/02

CPC分类号： A61K39/39 ,  A61K36/258 ,  A61K2039/55583 ,  A61K2039/55588 ,  Y10S514/885

摘要： The invention is directed to chemical processes of preparing fractions from North American Ginseng (Panax quinquefolium) and pharmaceutical compositions containing these fractions. The products of the present invention may be used to stimulate the production of cytokines and/or antibodies, or as therapeutics targeted at conditions characterized by low immunity, such as the common cold, influenza, chronic fatigue syndrome, AIDS and cancer.

摘要翻译： 本发明涉及从北美人参（Panax quinquefolium）制备级分的化学方法和含有这些级分的药物组合物。 本发明的产品可用于刺激细胞因子和/或抗体的产生，或作为针对低免疫性特征的治疗剂，例如感冒，流感，慢性疲劳综合征，艾滋病和癌症。

公开(公告)号：US20100260871A1

公开(公告)日：2010-10-14

申请号：US12600301

申请日：2007-05-16

申请人： Jacqueline Shan ,  Sandra C. Miller

发明人： Jacqueline Shan ,  Sandra C. Miller

IPC分类号： A61K36/258 ,  A61P35/02

CPC分类号： A61K36/258 ,  A61K31/715

摘要： The invention is directed to a method of treating hematological malignancies by administering to the subject ginseng fractions from North American ginseng (Panax quinquefolium). The present invention can be used to activate the proliferation of hemopoietic cells in a patient in need of treatment, or as a therapeutic targeted at conditions characterized by hematological malignancy, such as an abnormal proliferation of blood cells, lymphocytes, multiple myeloma, etc. The invention also includes a method of treating leukemia by activating the proliferation of natural killer (NK) cells and monocytes in the bone marrow and the spleen of the patient by administering at least one ginseng fraction selected from the group consisting of CVT-E002, PQ2, PQ223 and purified fractions from CVT-E002, PQ2 and PQ223. The present invention may be used to treat the hematological malignancy or as a supplement for patients undergoing chemotherapy or radiation therapy.

摘要翻译： 本发明涉及通过对来自北美人参（Panax quinquefolium）的受试者的人参成分施用治疗血液恶性肿瘤的方法。 本发明可用于激活需要治疗的患者中造血细胞的增殖，或用作以血液恶性肿瘤为特征的病症，如血细胞，淋巴细胞，多发性骨髓瘤等的异常增殖。 本发明还包括通过施用至少一种选自CVT-E002，PQ2，...的人参组分来激活患者的骨髓和脾脏中的天然杀伤（NK）细胞和单核细胞的增殖来治疗白血病的方法， PQ223和来自CVT-E002，PQ2和PQ223的纯化级分。 本发明可用于治疗血液恶性肿瘤或作为进行化疗或放射治疗的患者的补充。