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    Method for manufacturing isothiazole compound
    1.
    发明授权
    Method for manufacturing isothiazole compound 有权
    异噻唑化合物的制备方法

    公开(公告)号：US09353071B2

    公开(公告)日：2016-05-31

    申请号：US14432589

    申请日：2013-10-04

    申请人： IHARA CHEMICAL INDUSTRY CO., LTD.

    发明人： Takashi Abe

    IPC分类号： C07D275/03 ,  C07D275/02

    CPC分类号： C07D275/03 ,  C07D275/02

    摘要： An industrially preferred process for producing an isothiazole compound, particularly 3,4-dichloro-5-cyanoisothiazole, provides a safer industrial production process by avoiding the simultaneous use of an aprotic polar solvent such as N,N-dimethylformamide and chlorine. In addition, a production process which is economically preferred because an aprotic polar solvent, which is highly likely to become a part of waste, is not used.A process for producing an isothiazole compound represented by a general formula (3), wherein R is a cyano group or the like; and X is a chlorine atom or the like, which comprises heating a nitrile compound represented by a general formula (1), wherein R is as defined above, and sulfur, and then carrying out a reaction between the nitrile compound represented by the general formula (1), the sulfur and a halogen represented by a general formula (2), wherein X is as defined above.

    摘要翻译： 用于制备异噻唑化合物，特别是3,4-二氯-5-氰基异噻唑的工业上优选的方法通过避免同时使用非质子极性溶剂如N，N-二甲基甲酰胺和氯而提供更安全的工业生产方法。 此外，不使用非常有可能成为废物的一部分的非质子极性溶剂，因此经济上优选的制造方法。 一种制备由通式（3）表示的异噻唑化合物的方法，其中R是氰基等; X是氯原子等，其包括加热由通式（1）表示的腈化合物，其中R定义如上，和硫，然后进行由通式 （1）表示的硫和由通式（2）表示的卤素，其中X如上所定义。

    Process for producing isothiazole derivative
    3.
    发明授权
    Process for producing isothiazole derivative 有权
    异噻唑衍生物的制备方法

    公开(公告)号：US08563745B2

    公开(公告)日：2013-10-22

    申请号：US13318323

    申请日：2010-04-30

    申请人： Takayuki Nakamura ,  Hironobu Kumagai ,  Mahito Ogawa

    发明人： Takayuki Nakamura ,  Hironobu Kumagai ,  Mahito Ogawa

    IPC分类号： C07D275/03

    CPC分类号： C07D275/02 ,  C07D275/03

    摘要： A process for producing 3,4-dichloro-5-cyanoisothiazole represented by a general formula (3): the process comprising: reacting a nitrile compound represented by a general formula (1): (wherein “n” denotes an integer of 0 to 2), with sulfur chloride represented by a general formula (2): SmCl2  (2) (wherein “m” represents an integer of 1 to 2), or a mixture thereof in an aprotic polar solvent. There is provided a process for producing 3,4-dichloro-5-cyanoisothiazole, which is capable of suppressing by-production of a waste, without using a raw material having a strong toxicity; and is capable of providing a product having a higher purity in a high yield and efficiency in an industrial scale, in a simple manner.

    摘要翻译： 由通式（3）表示的制备3,4-二氯-5-氰基异噻唑的方法：该方法包括：使由通式（1）表示的腈化合物：其中“n”表示0至0的整数 2），由通式（2）表示的氯化硫：SmCl 2（2）（其中“m”表示1〜2的整数）或其在非质子极性溶剂中的混合物。 提供了不使用具有强毒性的原料的3,4-二氯-5-氰基异噻唑的制造方法，其能够抑制废弃物的副产物。 并且能够以简单的方式以高产率和高效率的工业规模提供具有较高纯度的产品。

    OPTICALLY ACTIVE DIFLUOROMETHANESULFONANILIDE DERIVATIVE AND HERBICIDE
    5.
    发明申请
    OPTICALLY ACTIVE DIFLUOROMETHANESULFONANILIDE DERIVATIVE AND HERBICIDE 审中-公开
    光学活性二聚异氰脲酸衍生物和除草剂

    公开(公告)号：US20110178299A1

    公开(公告)日：2011-07-21

    申请号：US13120800

    申请日：2009-06-10

    申请人： Jun Inoue ,  Hiroshi Kawasaki ,  Sohei Asakura

    发明人： Jun Inoue ,  Hiroshi Kawasaki ,  Sohei Asakura

    IPC分类号： C07D239/52

    CPC分类号： C07D239/52 ,  A01N43/54

    摘要： The present invention aims at providing an optically active difluoromethanesulfonanilide derivative exhibiting an excellent herbicidal activity at a low dose.An optically active (R)-2′-(4,6-dimethoxy-pyrimidin-2-yl)hydroxymethyl-1,1-difluoromethanesulfonanilide derivative is represented by the formula (I) (in the formula, R1 is a hydrogen atom, a C1-C4 alkyl group or a C1-C4 alkoxy C1-C4 alkyl group). and this difluoromethanesulfonanilide derivative is produced by subjecting to optical resolution a racemate of 2′-(4,6-dimethoxypyrimidin-2-yl)hydroxymethyl-1,1-difluoromethanesul-fonanilide derivative.

    摘要翻译： 本发明的目的在于提供一种在低剂量下表现出优异除草活性的光学活性二氟甲磺酰苯胺衍生物。 光学活性（R）-2' - （4,6-二甲氧基 - 嘧啶-2-基）羟甲基-1,1-二氟甲磺酰苯胺衍生物由式（I）表示（式中，R1是氢原子， C1-C4烷基或C1-C4烷氧基C1-C4烷基）。 该二氟甲磺酰苯胺衍生物是通过光学拆分2' - （4,6-二甲氧基嘧啶-2-基）羟甲基-1,1-二氟甲磺酰氟苯胺衍生物的外消旋物制得的。

    METHOD FOR PRODUCING 3-MERCAPTOANILINE COMPOUND
    7.
    发明申请
    METHOD FOR PRODUCING 3-MERCAPTOANILINE COMPOUND 有权
    3-MERCAPTOANINE化合物的制备方法

    公开(公告)号：US20100249462A1

    公开(公告)日：2010-09-30

    申请号：US12743389

    申请日：2008-11-28

    申请人： Kentaro Kawazoe

    发明人： Kentaro Kawazoe

    IPC分类号： C07C321/26 ,  C07C315/04

    CPC分类号： C07C319/02 ,  C07C303/22 ,  C07C309/86 ,  C07C323/34

    摘要： A method for producing a 3-mercaptoaniline compound, which is a known intermediate for a 3-(1H-1,2,4-triazol-1-yl)phenylsulfide derivative, useful as a pesticide, and a method for producing a compound which can be used as a starting material in producing the 3-mercaptoaniline compound are disclosed. In one embodiment the nitro group and the chlorosulfonyl group of a 3-nitrobenzenesulfonyl chloride compound represented by general formula (1): are reduced in the presence of an acid catalyst to produce a compound of general formula (2): In the above general formulas (1) and (2), R represents an alkyl group or a cyclic alkyl group, and X represents a halogen atom.

    摘要翻译： 作为可用作农药的3-（1H-1,2,4-三唑-1-基）苯硫醚衍生物的已知中间体的3-巯基苯胺化合物的制造方法及其制造方法 可以用作生产3-巯基苯胺化合物的原料。 在一个实施方案中，通式（1）表示的3-硝基苯磺酰氯化合物的硝基和氯磺酰基在酸催化剂的存在下还原，得到通式（2）的化合物：在上述通式 （1）和（2）中，R表示烷基或环状烷基，X表示卤素原子。

    Method for inhibiting the discoloration of methylenebisaniline compounds
    8.
    发明授权
    Method for inhibiting the discoloration of methylenebisaniline compounds 有权
    抑制亚甲基双苯胺化合物变色的方法

    公开(公告)号：US07632424B2

    公开(公告)日：2009-12-15

    申请号：US10583722

    申请日：2004-12-20

    申请人： Mato Nagasawa ,  Naoya Atsumi ,  Hirofumi Ichikawa

    发明人： Mato Nagasawa ,  Naoya Atsumi ,  Hirofumi Ichikawa

    IPC分类号： C09K15/18 ,  C09K15/32

    CPC分类号： C07C209/90 ,  C07C211/50

    摘要： A method for inhibiting the discoloration of methylenebisaniline compounds by adding a phosphine of the formula: (H)p—P—(R3)q (wherein R3 is an optionally substituted aryl group or an optionally substituted alkyl group; p is 0, 1 or 2 and q is 1, 2 or 3) to a compound of the formula: (wherein R1 and R2 are each independently a halogen atom or a C1-C6 alkyl group; a and b are each independently an integer of 0 to 4; m and n are each independently an integer of 1 to 5).

    摘要翻译： 通过添加下式的膦抑制亚甲基双苯胺化合物的变色的方法：（H）pP-（R3）q（其中R3是任选取代的芳基或任选取代的烷基; p是0,1或2和 q为1,2或3）与下式的化合物反应：（其中R 1和R 2各自独立地为卤素原子或C 1 -C 6烷基; a和b各自独立地为0至4的整数; m和n 各自独立地为1〜5的整数）。

    Process for producing substituted aniline compound
    9.
    发明授权
    Process for producing substituted aniline compound 失效
    制备取代苯胺化合物的方法

    公开(公告)号：US07531654B2

    公开(公告)日：2009-05-12

    申请号：US11790939

    申请日：2007-04-30

    申请人： Hidetaka Hiyoshi ,  Mahito Ogawa

    发明人： Hidetaka Hiyoshi ,  Mahito Ogawa

    IPC分类号： C07D239/52

    CPC分类号： C07D403/04 ,  C07C243/22 ,  C07D239/30 ,  C07D239/42 ,  C07D239/52

    摘要： A substitute aniline compound represented by the following formula (6): wherein, R1, R2 and R3 are each independently an alkyl group, an alkoxy group, an alkoxyalkyl group, a haloalkyl group, a carboxyl group, an alkoxycarbonyl group, an alkylcarboxamide group, a nitro group, an aryl group, an arylalkyl group, an aryloxy group, a halogen atom or a hydrogen atom; and X and Y are each independently a hydrogen atom, an alkyl group, an alkoxy group, an alkoxyalkyl group, a haloalkyl group, a carboxyl group, an alkoxycarbonyl group or halogen. A process for producing the compound formula (6) is also discussed.

    摘要翻译： 由下式（6）表示的替代苯胺化合物：其中，R 1，R 2和R 3各自独立地为烷基，烷氧基，烷氧基烷基，卤代烷基，羧基，烷氧基羰基，烷基甲酰胺基 硝基，芳基，芳基烷基，芳氧基，卤原子或氢原子; X和Y各自独立地为氢原子，烷基，烷氧基，烷氧基烷基，卤代烷基，羧基，烷氧基羰基或卤素。 还讨论了制备化合物式（6）的方法。

    Process for production of substituted aniline compound
    10.
    发明授权
    Process for production of substituted aniline compound 失效
    取代苯胺化合物的制备方法

    公开(公告)号：US07271263B2

    公开(公告)日：2007-09-18

    申请号：US10398025

    申请日：2001-10-15

    申请人： Hidetaka Hiyoshi ,  Mahito Ogawa

    发明人： Hidetaka Hiyoshi ,  Mahito Ogawa

    IPC分类号： C07D403/04 ,  C07D239/48

    CPC分类号： C07D403/04 ,  C07C243/22 ,  C07D239/30 ,  C07D239/42 ,  C07D239/52

    摘要： The present invention provides a process for producing a substituted aniline compound represented by the following general formula (6): (in the formula, R1, R2 and R3 are each independently an alkyl group, an alkoxy group, an alkoxyalkyl group, a haloalkyl group, a carboxyl group, an alkoxycarbonyl group, an alkyl-carboxamide group, a nitro group, an aryl group, an arylalkyl group, an aryloxy group, a halogen atom or a hydrogen atom; and X and Y are each independently a hydrogen atom, an alkyl group, an alkoxy group, an alkoxyalkyl group, a haloalkyl group, a carboxyl group, an alkoxycarbonyl group or a halogen atom), characterized by oxidizing a substituted indole compound represented by the following general formula (3): (in the formula, R1, R2, R3, X and Y have the same definitions as given above) to give rise to the ring opening of indole ring to produce an acetanilide compound represented by the following general formula (4): (in the formula, R1, R2, R3, X and Y have the same definitions as given above; and Ac is an acetyl group) and subjecting this compound to reduction and deacetylation, advantageously in industry.

    摘要翻译： 本发明提供一种制备由以下通式（6）表示的取代的苯胺化合物的方法：（式中，R 1，R 2，R 2和 > 3 各自独立地为烷基，烷氧基，烷氧基烷基，卤代烷基，羧基，烷氧基羰基，烷基 - 酰胺基，硝基，芳基，芳基烷基 芳氧基，卤素原子或氢原子; X和Y各自独立地为氢原子，烷基，烷氧基，烷氧基烷基，卤代烷基，羧基，烷氧基羰基或卤素 原子），其特征在于氧化由以下通式（3）表示的取代的吲哚化合物：（在式中，R 1，R 2，R 3， X和Y具有与上述相同的定义），以产生吲哚环的开环以产生由以下通式表示的乙酰苯胺化合物 （4）:(式中R 1，R 2，R 3，X和Y具有与上述相同的定义） ; 并且Ac是乙酰基），并且有利地在工业上使该化合物还原和脱乙酰化。