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公开(公告)号：US20210379006A1
公开(公告)日：2021-12-09
申请号：US17400266
申请日：2021-08-12
发明人： Massimo Baldacci
IPC分类号： A61K31/295 , A61P7/06 , A61K9/16
摘要： The object of the present invention is a product obtainable by spray-drying an aqueous solution comprising iron bis-glycinate chelate and alginic acid and/or water-soluble salts thereof, preferably sodium alginate, potassium alginate and/or magnesium alginate, the use of said product for the prevention and/or treatment of anaemia, preferably sideropenic anaemia, in humans, the pharmaceutical formulations containing it, and the use of said formulations for the prevention and/or treatment of anaemia, preferably sideropenic anaemia, in humans.
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公开(公告)号：US10028929B2
公开(公告)日：2018-07-24
申请号：US13005902
申请日：2011-01-13
申请人： Raffaella Scorza
发明人： Raffaella Scorza
IPC分类号： A61K31/245
摘要： The subject of the present invention is the use of aminaphtone for the preparation of a medicament for treating arteriophaties, in particular arteriophaties of a degenerative inflammatory type. Preferably, said medicament is formulated for oral administration.
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公开(公告)号：US4581371A
公开(公告)日：1986-04-08
申请号：US476499
申请日：1983-03-18
申请人： Massimo Baldacci
发明人： Massimo Baldacci
IPC分类号： C07D207/28 , A61K31/195 , A61K31/40 , A61K31/4015 , A61P37/04
CPC分类号： A61K31/195 , A61K31/40
摘要： The administration by oral route of a composition comprising arginine pyrrolidone carboxylate and lysine pyrrolidone carboxylate at a dose of 150 to 200 mg/kg of body weight has immunomodulating activity capable of restoring depressed immunodefenses.
摘要翻译： 以150-200mg / kg体重的剂量通过口服途径施用包含精氨酸吡咯烷酮羧酸盐和赖氨酸吡咯烷酮羧酸盐的组合物具有能够恢复抑制性免疫反应的免疫调节活性。
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公开(公告)号：US11213505B2
公开(公告)日：2022-01-04
申请号：US16816878
申请日：2020-03-12
发明人： Massimo Baldacci
IPC分类号： A61K31/295 , A61P7/06 , A61K9/16
摘要： The object of the present invention is a product obtainable by spray-drying an aqueous solution comprising iron bis-glycinate chelate and alginic acid and/or water-soluble salts thereof, preferably sodium alginate, potassium alginate and/or magnesium alginate, the use of said product for the prevention and/or treatment of anaemia, preferably sideropenic anaemia, in humans, the pharmaceutical formulations containing it, and the use of said formulations for the prevention and/or treatment of anaemia, preferably sideropenic anaemia, in humans.
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公开(公告)号：US10456374B2
公开(公告)日：2019-10-29
申请号：US16297398
申请日：2019-03-08
发明人： Massimo Baldacci
IPC分类号： A61K31/4015 , A61K31/728 , A61K9/00 , A61K33/34
摘要： The present invention relates to pyrrolidone carboxylic acid (PCA) and/or pharmaceutically acceptable salts or derivatives thereof for use in the treatment of ocular diseases and/or disorders.A further object of the present invention are compositions comprising pyrrolidone carboxylic acid (PCA) and/or pharmaceutically acceptable salts or derivatives thereof, at least one physiologically acceptable excipient, and optionally at least one additional active ingredient for use in the treatment of ocular diseases and/or disorders.
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公开(公告)号：US10272067B2
公开(公告)日：2019-04-30
申请号：US15558524
申请日：2016-04-06
发明人： Massimo Baldacci
IPC分类号： A61K31/4015 , A61K9/00 , A61K31/728 , A61K33/34
摘要： The present invention relates to pyrrolidone carboxylic acid (PCA) and/or pharmaceutically acceptable salts or derivatives thereof for use in the treatment of ocular diseases and/or disorders.A further object of the present invention are compositions comprising pyrrolidone carboxylic acid (PCA) and/or pharmaceutically acceptable salts or derivatives thereof, at least one physiologically acceptable excipient, and optionally at least one additional active ingredient for use in the treatment of ocular diseases and/or disorders.
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公开(公告)号：US11865099B2
公开(公告)日：2024-01-09
申请号：US17400266
申请日：2021-08-12
发明人： Massimo Baldacci
IPC分类号： A61K31/295 , A61P7/06 , A61K9/16
CPC分类号： A61K31/295 , A61K9/1652 , A61P7/06
摘要： The object of the present invention is a product obtainable by spray-drying an aqueous solution comprising iron bis-glycinate chelate and alginic acid and/or water-soluble salts thereof, preferably sodium alginate, potassium alginate and/or magnesium alginate, the use of said product for the prevention and/or treatment of anaemia, preferably sideropenic anaemia, in humans, the pharmaceutical formulations containing it, and the use of said formulations for the prevention and/or treatment of anaemia, preferably sideropenic anaemia, in humans.
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公开(公告)号：US20220299489A1
公开(公告)日：2022-09-22
申请号：US17608907
申请日：2020-05-05
发明人： Massimo BALDACCI
IPC分类号： G01N30/86 , G01N33/15 , G01N30/36 , C07C229/60
摘要： The present invention refers to a mixture of positional isomers of aminaphtone, to an aminaphtone product comprising said mixture and to a new method of high-performance liquid chromatography (HPLC) useful for the characterization of aminaphtone. The method allows to identify in the positional isomers of which the aminaphtone in a product containing them, and can be used to choose lots of aminaphtone suitable for pharmaceutical use.
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9.发明授权Conjugate of 9-(2-hydroxyethoxymethyl)-guanine with lactosaminated human albumin, process for the preparation thereof and pharmaceutical compositions containing it 失效9-（2-羟基乙氧基甲基） - 鸟嘌呤与乳糖胺化人白蛋白的缀合物，其制备方法和含有它的药物组合物
公开(公告)号：US4725672A
公开(公告)日：1988-02-16
申请号：US921209
申请日：1986-10-21
CPC分类号： A61K47/48284 , A61K38/38
摘要： A conjugate of 9-(2-hydroxyethoxymethyl)-guanine with lactosaminated human albumin is therapeutically more efficacious than the free drug in the treatment of chronical hepatitis induced from Virus B. For the preparation of the conjugate an aqueous solution of 9-(2-hydroxyethoxymethyl)-guanine in form of a derivative, particularly monophosphate, and an aqueous solution of lactosaminated human albumin are reacted in the presence of 1-ethyl-3-(dimethylaminopropyl)-carbodiimide, by adjusting the pH to the value of 7.5 and by maintaining the reaction mixture for 24 hours under stirring and in the dark.
摘要翻译： 9-（2-羟基乙氧基甲基） - 鸟嘌呤与乳糖胺化人白蛋白的结合物在治疗由病毒B诱导的慢性肝炎方面比游离药物治疗更有效。为了制备缀合物，将9-（2- 羟基乙氧基甲基） - 鸟嘌呤形式，特别是单磷酸酯和乳糖胺化人白蛋白水溶液在1-乙基-3-（二甲基氨基丙基） - 碳二亚胺的存在下，通过将pH调节至7.5，并通过 在搅拌下和黑暗中将反应混合物保持24小时。
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