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公开(公告)号：US20210370346A1
公开(公告)日：2021-12-02
申请号：US17403152
申请日：2021-08-16
IPC分类号： B05C17/005 , B05C21/00 , F16K15/04 , F16K11/10
摘要： Apparatuses and methods related to a high pressure fluid processing device having a dual check valve setup that can be quickly and easily maintained with replacement parts are disclosed herein. In a general example embodiment, a high pressure processing device includes a body including a first surface having a first recess, a second surface having a second recess, and a third surface having a third recess, a first subassembly at least partially inserted into the first recess of the body, the first subassembly including a first check valve, a second subassembly at least partially inserted into the second recess of the body, the second subassembly including a second check valve, and a third subassembly at least partially inserted into the third recess of the body, the third subassembly coupling the body to a fluid driving mechanism, wherein the first subassembly, second subassembly and third subassembly are configured to be independently attachable to and detachable from the first recess, second recess and third recess, respectively.
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公开(公告)号：US10583408B2
公开(公告)日：2020-03-10
申请号：US15492440
申请日：2017-04-20
发明人： Thomai Panagiotou , Yang Su
摘要： Apparatuses and methods that reduce cavitation in interaction chambers are described herein. In an embodiment, an interaction chamber for a fluid processor or fluid homogenizer includes an inlet chamber having an inlet hole and a bottom end, an outlet chamber having an outlet hole and a top end, a microchannel placing the inlet hole in fluid communication with the outlet hole, wherein an entrance to the microchannel from the inlet chamber is offset a distance from the bottom end, and at least one of: (i) a tapered fillet located on a side wall of the microchannel at the microchannel entrance; (ii) a side wall of the microchannel converging inwardly from the inlet chamber to the outlet chamber; (iii) a top wall and/or bottom wall of the microchannel angled from the inlet chamber to the outlet chamber; and (iv) a top fillet that extends around a diameter of inlet chamber.
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公开(公告)号：US09931600B2
公开(公告)日：2018-04-03
申请号：US14796160
申请日：2015-07-10
CPC分类号： B01F5/0256 , B01F3/0861 , B01F13/0059 , B01F2215/0032
摘要： A mixing assembly includes an inlet, an outlet and a mixing chamber, the inlet is fluidly connected to the outlet through a plurality of micro fluid flow paths in a direction perpendicular from the inlet. The micro fluid flow paths fluidly connect to the perpendicular inlet via a transition portion. The micro fluid flow paths are constructed radially inwardly to a concentration area in the mixing chamber. By directing multiple fluid flows to a concentrated area within the mixing chamber at high speeds, the energy dissipated at the point of collision is maximized, which helps to increase consistency and quality of mixing, and to reduce particle size of the fluid in the mixing chamber.
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公开(公告)号：US11654452B2
公开(公告)日：2023-05-23
申请号：US17403152
申请日：2021-08-16
IPC分类号： F16K15/04 , B05C17/005 , B05C21/00 , F16K11/10
CPC分类号： B05C17/00553 , B05C17/00576 , B05C21/00 , F16K11/105 , F16K15/042 , F16K15/044
摘要： Apparatuses and methods related to a high pressure fluid processing device having a dual check valve setup that can be quickly and easily maintained with replacement parts are disclosed herein. In a general example embodiment, a high pressure processing device includes a body including a first surface having a first recess, a second surface having a second recess, and a third surface having a third recess, a first subassembly at least partially inserted into the first recess of the body, the first subassembly including a first check valve, a second subassembly at least partially inserted into the second recess of the body, the second subassembly including a second check valve, and a third subassembly at least partially inserted into the third recess of the body, the third subassembly coupling the body to a fluid driving mechanism, wherein the first subassembly, second subassembly and third subassembly are configured to be independently attachable to and detachable from the first recess, second recess and third recess, respectively.
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公开(公告)号：US11519512B2
公开(公告)日：2022-12-06
申请号：US17326667
申请日：2021-05-21
发明人： Rachel Otte , Ahmad Shehata , Jocemar Ramina , Marco Catalani , David Harney , John Michael Bernard , Michael Ratigan , Harshit Kumar Patel
摘要： A new and innovative high-pressure priming valve is provided for use in high-pressure fluid systems that require a high level of fluid purity. The priming valve includes at least three ports, some of which are angled. The priming valve also includes a needle that variably blocks and unblocks a pathway to one of the ports between normal operation and a priming operation, respectively. The priming valve includes a sealing insert positioned below a stack of washers that maintain the needle's alignment in response to high fluid pressures exerted on the needle. The sealing insert helps prevent fluid from contacting the stack of washers, which helps prevent biological growth within the valve. The angled ports help facilitate priming valve drainage to further help prevent biological growth. By helping prevent biological growth, the sealing insert helps prevent fluid contamination and enables the priming valve to be utilized for high-purity fluid applications.
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公开(公告)号：US10898869B2
公开(公告)日：2021-01-26
申请号：US16420718
申请日：2019-05-23
摘要： A compact interaction chamber is used to cause high shear, impact forces, and cavitation to reduce particle size and mix fluids while reducing waste and holdup volume. A first housing made of stainless steel holds an inlet mixing chamber element and an outlet mixing chamber element in a female bore using thermal expansion. The inlet and outlet mixing chamber elements are manufactured so that the diameter of the cooled female bore is slightly smaller than the diameter of the mixing chamber elements. The first housing is heated, expanding the diameter of the female bore enough to allow the inlet and outlet mixing chamber elements to be inserted. After the mixing chamber elements are inserted and aligned within the female bore, the first housing is allowed to cool. Once cooled, the female bore contracts and applies sufficient hoop stress to securely hold the mixing chamber elements during high shear force mixing.
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公开(公告)号：US09199209B2
公开(公告)日：2015-12-01
申请号：US13085939
申请日：2011-04-13
CPC分类号： B01F5/0256 , B01F3/0865 , B01F13/0059 , B01F2215/0032
摘要： A mixing assembly includes an inlet, an outlet and a mixing chamber, the inlet is fluidly connected to the outlet through a plurality of micro fluid flow paths in a direction perpendicular from the inlet. The micro fluid flow paths fluidly connect to the perpendicular inlet via a curved transition portion. The curved transition portion provides a more efficient flow path for the fluid to travel from the inlet to the micro fluid flow paths to the mixing chamber. By transitioning the direction change, flow resistance is decreased, and the fluid flow rate and shear rate is increased. Increased fluid flow rate and shear rate helps to increase consistency and quality of mixing, and to reduce particle size of the fluid in the mixing chamber.
摘要翻译： 混合组件包括入口，出口和混合室，入口通过多个微流体流动路径在与入口垂直的方向上流体地连接到出口。 微流体流动路径经由弯曲的过渡部分流体地连接到垂直入口。 弯曲的过渡部分提供了一种更有效的流动路径，用于流体从入口到微流体流动路径行进到混合室。 通过转变方向变化，流阻减小，流体流速和剪切速率增加。 增加的流体流速和剪切速率有助于提高混合的一致性和质量，并减少混合室中的流体的粒径。
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8.发明授权Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems 有权运输和反应系统的纳米颗粒生成和过程强化的装置和方法公开(公告)号：US08367004B2
公开(公告)日：2013-02-05
申请号：US13481193
申请日：2012-05-25
CPC分类号： B01J19/0093 , B01F5/0256 , B01F13/0059 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , Y02P20/582
摘要： Apparatus, systems and methods are provided that utilize microreactor technology to achieve desired mixing and interaction at a micro and/or molecular level between and among feed stream constituents. Feed streams are fed to an intensifier pump at individually controlled rates, e.g., based on operation of individually controlled feed pumps. The time during which first and second feed streams are combined/mixed prior to introduction to the microreactor is generally minimized, thereby avoiding potential reactions and other constituent interactions prior to micro- and/or nano-scale interactions within the microreactor. Various microreactor designs/geometries may be employed, e.g., “Z” type single or multi-slot geometries and “Y” type single or multi-slot geometries. Various applications benefit from the disclosure, including emulsion, crystallization, encapsulation and reaction processes.
摘要翻译： 提供了装置，系统和方法，其利用微反应器技术在进料流组分之间的微量和/或分子水平实现期望的混合和相互作用。 进料流以独立控制的速率进料到增压泵，例如基于单独控制的进料泵的操作。 在引入微反应器之前将第一和第二进料流混合/混合的时间通常最小化，从而避免在微反应器内的微量和/或纳米级相互作用之前的潜在反应和其它组成相互作用。 可以采用各种微反应器设计/几何形状，例如Z型单槽或多槽几何形状和Y型单槽或多槽几何形状。 各种应用受益于本公开，包括乳液，结晶，包封和反应过程。
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9.发明申请公开(公告)号：US20120236680A1
公开(公告)日：2012-09-20
申请号：US13481193
申请日：2012-05-25
CPC分类号： B01J19/0093 , B01F5/0256 , B01F13/0059 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , Y02P20/582
摘要： Apparatus, systems and methods are provided that utilize microreactor technology to achieve desired mixing and interaction at a micro and/or molecular level between and among feed stream constituents. Feed streams are fed to an intensifier pump at individually controlled rates, e.g., based on operation of individually controlled feed pumps. The time during which first and second feed streams are combined/mixed prior to introduction to the microreactor is generally minimized, thereby avoiding potential reactions and other constituent interactions prior to micro- and/or nano-scale interactions within the microreactor. Various microreactor designs/geometries may be employed, e.g., “Z” type single or multi-slot geometries and “Y” type single or multi-slot geometries. Various applications benefit from the disclosure, including emulsion, crystallization, encapsulation and reaction processes.
摘要翻译： 提供了装置，系统和方法，其利用微反应器技术在进料流组分之间的微量和/或分子水平实现期望的混合和相互作用。 进料流以独立控制的速率进料到增压泵，例如基于单独控制的进料泵的操作。 在引入微反应器之前将第一和第二进料流混合/混合的时间通常最小化，从而避免在微反应器内的微量和/或纳米级相互作用之前的潜在反应和其它组成相互作用。 可以采用各种微反应器设计/几何形状，例如“Z”型单槽或多槽几何形状和“Y”型单槽或多槽几何形状。 各种应用受益于本公开，包括乳液，结晶，包封和反应过程。
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公开(公告)号：US11090680B2
公开(公告)日：2021-08-17
申请号：US15872332
申请日：2018-01-16
IPC分类号： F16K15/04 , B05C17/005 , B05C21/00 , F16K11/10
摘要： Apparatuses and methods related to a high pressure fluid processing device having a dual check valve setup that can be quickly and easily maintained with replacement parts are disclosed herein. In a general example embodiment, a high pressure processing device includes a body including a first surface having a first recess, a second surface having a second recess, and a third surface having a third recess, a first subassembly at least partially inserted into the first recess of the body, the first subassembly including a first check valve, a second subassembly at least partially inserted into the second recess of the body, the second subassembly including a second check valve, and a third subassembly at least partially inserted into the third recess of the body, the third subassembly coupling the body to a fluid driving mechanism, wherein the first subassembly, second subassembly and third subassembly are configured to be independently attachable to and detachable from from the first recess, second recess and third recess, respectively.
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