公开(公告)号：US5690952A

公开(公告)日：1997-11-25

申请号：US485870

申请日：1995-06-07

申请人： Judy A. Magruder ,  James B. Eckenhoff, deceased ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

发明人： Judy A. Magruder ,  James B. Eckenhoff, deceased ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

IPC分类号： A61K9/00 ,  A61K9/52 ,  A61F2/02 ,  A61K9/22

CPC分类号： A61K9/0004

摘要： A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure. The passageway (13) is preferably sized to compensate for slight variations in the efflux of the beneficial agent and to maintaining a sufficient volumetric outflow rate of beneficial agent in order to minimize influx of biological fluids from the external environment back into the device once the seal (30) is expelled.

摘要翻译： 公开了用于将诸如生长激素或其类似物或衍生物的流体敏感有益试剂（7）递送给动物如牛的递送系统（10）。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 提供出口通道用于将有益剂输送到动物的内部隔室（18）。 出口通道用蜡密封件（30）密封，当密封件（10）中的内部压力达到预定的“爆裂”压力时，该密封件通过通道（13）排出。 通道（13）优选的尺寸适于补偿有益剂的流出中的轻微变化并维持有益剂的足够的体积流出速率，以便最小化生物流体从外部环境流入装置中，一旦密封 （30）被排出。