公开(公告)号：US07718445B2

公开(公告)日：2010-05-18

申请号：US12059427

申请日：2008-03-31

申请人： Mark Martin

发明人： Mark Martin

IPC分类号： G01N33/543 ,  C12Q1/00

CPC分类号： C12N11/00 ,  C12N13/00 ,  Y10S436/806 ,  Y10T436/115831 ,  Y10T436/116664 ,  Y10T436/24

摘要： The present invention concerns a novel means by which specific chosen reactions can be accelerated through the use of a new type of artificial enzyme. The invention allows specific reactions to occur at an accelerated rate, even in the presence of other non-chosen molecules, which may be very similar in structure to the chosen reactant. The reactions may be stoichiometric or catalytic.

摘要翻译： 本发明涉及通过使用新型人造酶可以加速特定选择的反应的新方法。 本发明允许特定的反应以加速的速率发生，甚至在存在其它未选择的分子的情况下，其结构可能与选择的反应物非常相似。 反应可以是化学计量的或催化的。

公开(公告)号：US20070087377A1

公开(公告)日：2007-04-19

申请号：US11641151

申请日：2006-12-18

申请人： Mark Martin

发明人： Mark Martin

IPC分类号： C12Q1/68 ,  C12N1/08 ,  C07H21/04

CPC分类号： G01N33/6803

摘要： A process is disclosed by which a polynucleotide is directly synthesized from the peptide or protein that it encodes without the need for sequencing (or sequence analysis) of the peptide or protein. Information contained in the sequence of the peptide or protein is directly coupled, by the process of reverse translation, to the synthesis of the polynucleotide. The usefulness of reverse translation is that it facilitates the amplification of information held in the amino acid sequence (the primary structure) of an unknown protein or peptide. Amplification is useful for, among other things, the identification and/or scientific investigation of the peptide or protein.

公开(公告)号：US07348182B2

公开(公告)日：2008-03-25

申请号：US10234092

申请日：2002-09-05

申请人： Mark T. Martin ,  Richard Saul

发明人： Mark T. Martin ,  Richard Saul

IPC分类号： G01N33/543 ,  C12M1/00

CPC分类号： C12N13/00 ,  B01J19/126 ,  C12N11/00 ,  G01N1/44 ,  G01N33/5436 ,  G01N33/54393 ,  Y10S436/806 ,  Y10T436/115831 ,  Y10T436/116664 ,  Y10T436/24

摘要： The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special chips using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many small scale chemical transformations including those used in protein chemistry and in combinatorial chemistry.

摘要翻译： 本发明涉及可以制备化学制剂的新型方法。 使用微波能量的特殊芯片可以加速反应。 这些芯片含有有效吸收微波能量的材料，导致化学反应速率增加。 本发明在许多小规模的化学转化中是重要的，包括用于蛋白质化学和组合化学的化学转化。

公开(公告)号：US07351590B2

公开(公告)日：2008-04-01

申请号：US09968517

申请日：2001-10-02

申请人： Mark Martin

发明人： Mark Martin

IPC分类号： G01N33/543 ,  C12M1/00

CPC分类号： C12N11/00 ,  C12N13/00 ,  Y10S436/806 ,  Y10T436/115831 ,  Y10T436/116664 ,  Y10T436/24

摘要： The present invention concerns a novel means by which specific chosen reactions can be accelerated through the use of a new type of artificial enzyme. The invention allows specific reactions to occur at an accelerated rate, even in the presence of other non-chosen molecules, which may be very similar in structure to the chosen reactant. The reactions may be stoichiometric or catalytic.

摘要翻译： 本发明涉及通过使用新型人造酶可以加速特定选择的反应的新方法。 本发明允许特定的反应以加速的速率发生，甚至在存在其它未选择的分子的情况下，其结构可能与选择的反应物非常相似。 反应可以是化学计量的或催化的。

公开(公告)号：US07169894B2

公开(公告)日：2007-01-30

申请号：US10286796

申请日：2002-11-04

申请人： Mark T. Martin

发明人： Mark T. Martin

IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  G01N33/53 ,  C07H21/04

CPC分类号： G01N33/6803

摘要： A process is disclosed by which a polynucleotide is directly synthesized from the peptide or protein that it encodes without the need for sequencing (or sequence analysis) of the peptide or protein. Information contained in the sequence of the peptide or protein is directly coupled, by the process of reverse translation, to the synthesis of the polynucleotide. The usefulness of reverse translation is that it facilitates the amplification of information held in the amino acid sequence (the primary structure) of an unknown protein or peptide. Amplification is useful for, among other things, the identification and/or scientific investigation of the peptide or protein.

摘要翻译： 公开了一种方法，通过该方法，多核苷酸从其编码的肽或蛋白质直接合成，而不需要肽或蛋白质的测序（或序列分析）。 肽或蛋白质序列中包含的信息通过反向翻译的过程与多核苷酸的合成直接偶联。 反向翻译的有用性是它有助于扩增未知蛋白质或肽的氨基酸序列（一级结构）中保存的信息。 除了别的以外，扩增可用于肽或蛋白质的鉴定和/或科学研究。

公开(公告)号：US08431414B2

公开(公告)日：2013-04-30

申请号：US13341109

申请日：2011-12-30

申请人： Mark T. Martin

发明人： Mark T. Martin

IPC分类号： G01N33/543

CPC分类号： C12N11/00 ,  C12N13/00 ,  G01N33/5436 ,  G01N33/54393

摘要： The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special cartridges using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many chemical transformations including those used in protein chemistry, in nucleic acid chemistry, in analytical chemistry, and in the polymerase chain reaction.

摘要翻译： 本发明涉及可以制备化学制剂的新型方法。 使用微波能量的特殊墨盒可以加速反应。 这些芯片含有有效吸收微波能量的材料，导致化学反应速率增加。 本发明在许多化学转化中是重要的，包括在蛋白质化学，核酸化学，分析化学和聚合酶链反应中使用的化学转化。

公开(公告)号：US08309367B2

公开(公告)日：2012-11-13

申请号：US11105460

申请日：2005-04-14

申请人： Richard Saul ,  Mark T. Martin

发明人： Richard Saul ,  Mark T. Martin

IPC分类号： G01N33/53

CPC分类号： C12N13/00 ,  B01J19/126 ,  C12N11/00 ,  G01N1/44 ,  G01N33/5436 ,  G01N33/54393 ,  Y10S436/806 ,  Y10T436/115831 ,  Y10T436/116664 ,  Y10T436/24

摘要： The present invention concerns a novel means by which liquids can be moved or mixed. Microwaves strike and heat materials that are highly susceptible to microwave heating. The susceptible materials are on, within, or near materials that melt or change shape in response to temperature increases. Upon microwave irradiation, these materials change shape (e.g., shrink or melt), causing the movement of liquids. The invention is important in many microfluidics applications, especially in biomedical analysis, where it is valuable to be able to move small volumes of liquids (e.g., on a microarray chip).

摘要翻译： 本发明涉及可移动或混合液体的新颖手段。 微波冲击和加热材料，高度易受微波加热。 敏感材料是在温度升高时熔化或变形的材料中，内部或附近。 在微波照射下，这些材料变形（例如，收缩或熔化），导致液体的移动。 本发明在许多微流体应用中是重要的，特别是在生物医学分析中，其能够移动小体积液体（例如，在微阵列芯片上）是有价值的。

公开(公告)号：US20050191708A1

公开(公告)日：2005-09-01

申请号：US11105460

申请日：2005-04-14

申请人： Richard Saul ,  Mark Martin

发明人： Richard Saul ,  Mark Martin

IPC分类号： C12N11/00 ,  C12N13/00 ,  G01N33/543 ,  H05B6/80 ,  G01N33/53

CPC分类号： C12N13/00 ,  B01J19/126 ,  C12N11/00 ,  G01N1/44 ,  G01N33/5436 ,  G01N33/54393 ,  Y10S436/806 ,  Y10T436/115831 ,  Y10T436/116664 ,  Y10T436/24

摘要： The present invention concerns a novel means by which liquids can be moved or mixed. Microwaves strike and heat materials that are highly susceptible to microwave heating. The susceptible materials are on, within, or near materials that melt or change shape in response to temperature increases. Upon microwave irradiation, these materials change shape (e.g., shrink or melt), causing the movement of liquids. The invention is important in many microfluidics applications, especially in biomedical analysis, where it is valuable to be able to move small volumes of liquids (e.g., on a microarray chip).

摘要翻译： 本发明涉及可移动或混合液体的新颖手段。 微波冲击和加热材料，高度易受微波加热。 敏感材料是在温度升高时熔化或变形的材料中，内部或附近。 在微波照射下，这些材料变形（例如，收缩或熔化），导致液体的移动。 本发明在许多微流体应用中是重要的，特别是在生物医学分析中，其能够移动小体积液体（例如，在微阵列芯片上）是有价值的。