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309 条记录 (耗时 0.039 秒)

    Selective particles transfer from one device to another
    5.
    发明授权
    Selective particles transfer from one device to another 有权

    公开(公告)号：US11384326B2

    公开(公告)日：2022-07-12

    申请号：US15777501

    申请日：2016-11-18

    申请人： NATIONAL HEALTH RESEARCH INSTITUTES

    发明人： Chia-Hsien S. Hsu ,  Ching-Hui Lin ,  Duane S. Juang ,  Hao-Chen Chang

    IPC分类号： C12M3/06 ,  B01L3/00 ,  C12M1/32 ,  C12M1/00 ,  C12M1/26 ,  C12M1/16

    摘要： A target particle transferring device is disclosed, which comprises: (a) a substrate with a thickness of T and a width of W, having top and bottom portions, the top portion having a top surface and the bottom portion having a bottom surface; (b) a notch structure formed in the bottom portion of the substrate, comprising: a groove with a width of W1, located at a distance oft below the top surface of the substrate, wherein the groove is formed in the bottom portion from the bottom surface extending toward the top portion; and (c) a target substrate portion with a width of W2 and a thickness of T, located in the top and bottom portions of the substrate and being surrounded by the groove. Methods of transferring a target particle from one device to another is also disclosed.

    METHOD FOR TREATING AMYLOIDOGENIC DISEASE
    6.
    发明申请
    METHOD FOR TREATING AMYLOIDOGENIC DISEASE 有权

    公开(公告)号：US20220152090A1

    公开(公告)日：2022-05-19

    申请号：US17454748

    申请日：2021-11-12

    申请人： NATIONAL HEALTH RESEARCH INSTITUTES

    发明人： Shu-Yi LIN ,  Jyh-Lyh JUANG ,  Jinq-Chyi LEE

    IPC分类号： A61K31/739 ,  C07H13/06 ,  A61K31/7024 ,  A61P25/28

    摘要： The present disclosure relates to a method for treating or preventing or delaying the onset or progression of an amyloidogenic disease in a subject in need, comprising administering a pharmaceutical composition comprising a therapeutically effective amount of amphiphilic liposaccharide to the subject. The present disclosure also relates to a method for selecting an agent for treating or preventing or delaying the onset or progression of an amyloidogenic disease and a novel liposaccharide.

    COMPOUNDS FOR USES IN PHARMACOLOGICAL INDUCTION OF HBF FOR TREATMENT OF SICKLE CELL DISEASE AND ß-THALASSEMIA
    7.
    发明申请
    COMPOUNDS FOR USES IN PHARMACOLOGICAL INDUCTION OF HBF FOR TREATMENT OF SICKLE CELL DISEASE AND ß-THALASSEMIA 有权

    公开(公告)号：US20220152036A1

    公开(公告)日：2022-05-19

    申请号：US17439630

    申请日：2020-03-25

    申请人： Academia Sinica ,  National Health Research Institutes

    发明人： Weir-Torn JIAANG ,  Che-Kun James SHEN

    IPC分类号： A61K31/52 ,  A61P7/06 ,  C07D473/16 ,  C07D473/18 ,  A61K31/5377

    摘要： Provided herein are compounds of Formula (I). The compounds described herein are useful in treating a disease associated with the expression of endogenous embryonic/fetal globin (e.g., γ globin) in erythrocytes (e.g., treating β-thalassemia and/or sickle cell disease through at least the induction of the globin gene expression in erythrocytes), and/or anemia (β-thalassemia and/or sickle cell anemia). The compounds described herein are useful in treating, delaying, and/or preventing the adverse effects of β-thalassemia and/or sickle cell disease, inducing γ globin production, and/or inducing the expression of embryonic/fetal globin genes in a subject, cell, tissue, or biological sample. Also provided in the present disclosure are pharmaceutical compositions, kits, and methods of using the compounds for inducing γ globin production described herein and for treating any of the target diseases described herein.

    HIGH-EFFICIENCY SINGLE-CELL COLLECTION METHOD
    8.
    发明申请
    HIGH-EFFICIENCY SINGLE-CELL COLLECTION METHOD 有权

    公开(公告)号：US20220143595A1

    公开(公告)日：2022-05-12

    申请号：US17523542

    申请日：2021-11-10

    申请人： National Health Research Institutes

    发明人： Chia-Hsien HSU ,  Chuan-Feng YEH

    IPC分类号： B01L3/02 ,  C12N1/02

    摘要： This invention provides a high-efficient single-cell collection method using a specially designed collection well and collection pipet tip for particle/cell collection from the collection well. The structures of the collection well and pipet tip eliminate fluidic dead volume in the collection, resulting in all (or most) of the particles/cells can be brought into the collection pipette tip with the flow. The advantages of this invention in cell manipulation include high cell collection efficiency, low cell damage and easy operation procedure.

    Nanoemulsion adjuvant for nasal mucosa and preparation method thereof
    9.
    发明授权
    Nanoemulsion adjuvant for nasal mucosa and preparation method thereof 有权

    公开(公告)号：US11160862B2

    公开(公告)日：2021-11-02

    申请号：US16172207

    申请日：2018-10-26

    申请人： NATIONAL HEALTH RESEARCH INSTITUTES

    发明人： Ming-Hsi Huang ,  Chung-Hsiung Huang ,  Chiung-Yi Huang

    IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P35/00

    摘要： The invention provides a nanoemulsion adjuvant and a preparation method thereof, which are composed of the following components: a continuous aqueous phase containing H2O molecules, an oil phase material containing fats and oils, and an emulsion system for stabilizing the interface between the continuous aqueous phase and the oil phase, and the emulsion system is an emulsifier mixture. The adjuvant is characterized in that the emulsion system does not contain an ionic emulsifier and the particle size of the emulsion is between 20 and 200 nanometers. The use of the nanoemulsion adjuvant can prevent toxicity and possible harm of ionic emulsifiers to human cells, and provide a vaccine preparation capable of eliciting a high degree of immune response.

    SUB-NANOMETER GOLD STICKER AND METHODS FOR PROTECTING AGAINST ENDOTOXIN-INDUCED SEPSIS THEREOF
    10.
    发明申请
    SUB-NANOMETER GOLD STICKER AND METHODS FOR PROTECTING AGAINST ENDOTOXIN-INDUCED SEPSIS THEREOF 有权

    公开(公告)号：US20210077526A1

    公开(公告)日：2021-03-18

    申请号：US17041653

    申请日：2018-03-27

    申请人： NATIONAL HEALTH RESEARCH INSTITUTES

    发明人： Shu Yi LIN

    IPC分类号： A61K33/242 ,  C09D179/02

    摘要： A sub-nanometer gold sticker for blocking efficiently endotoxin activity to protect against sepsis is disclosed. The sub-nanometer gold sticker comprises a gold nanocluster that serves as a flake-like substrate and a coating of short alkyl motifs that act as an adhesive, allowing the sub-nanometer gold sticker to dock with LPS by compacting the intramolecular hydrocarbon chain-chain distance (d-spacing) of lipid A, an endotoxicity active site that can cause overwhelming cytokine induction resulting in sepsis progression. Methods of blocking endotoxin activity, and suppressing pro-inflammatory cytokines are also disclosed. Also disclosed is a method of protecting against endotoxin-induced sepsis via increasing critical micelle concentration for the inhibition of LPS non-lamellar aggregation.