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1.发明申请NOVEL (PYRROLOQUINOXALINYL) PYRAZINECARBOHYDRAZIDE-OXALIC ACID CO-CRYSTAL FOR TREATMENT OF CANCER AND OTHER DISEASES 有权新型（吡咯烷氧基）吡咯烷酮氧化亚油酸晶体治疗癌症及其他疾病公开(公告)号：US20110034473A1
公开(公告)日：2011-02-10
申请号：US12937245
申请日：2009-04-08
IPC分类号： A61K31/4985 , A61P35/00 , A61P35/02 , C07D487/04
CPC分类号： C07D487/04
摘要： A novel co-crystal of N′-(7-fluoropyrrolo[1,2a]quinoxalin-4-yl)pyrazine-2-carbohydrazide with oxalic acid is disclosed. The disclosed oxalic acid co-crystal demonstrates cancer cell growth inhibition and is more bioavailable than the corresponding free base when administered as a suspension.
摘要翻译： 公开了N' - （7-氟吡咯并[1,2a]喹喔啉-4-基）吡嗪-2-碳酰肼与草酸的新型共晶体。 所公开的草酸共晶体表现为癌细胞生长抑制，并且当作为悬浮液施用时比相应的游离碱更具生物利用度。
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2.发明授权(Pyrroloquinoxalinyl) pyrazinecarbohydrazide-oxalic acid co-crystal for treatment of cancer and other diseases 有权（吡咯喹喔啉基）吡嗪碳酰肼 - 草酸共晶，用于治疗癌症和其他疾病公开(公告)号：US08058437B2
公开(公告)日：2011-11-15
申请号：US12937245
申请日：2009-04-08
IPC分类号： C07D241/42 , A61K31/498
CPC分类号： C07D487/04
摘要： A novel co-crystal of N′-(7-fluoropyrrolo[1,2a]quinoxalin-4-yl)pyrazine-2-carbohydrazide with oxalic acid is disclosed. The disclosed oxalic acid co-crystal demonstrates cancer cell growth inhibition and is more bioavailable than the corresponding free base when administered as a suspension.
摘要翻译： 公开了N' - （7-氟吡咯并[1,2a]喹喔啉-4-基）吡嗪-2-碳酰肼与草酸的新型共晶体。 所公开的草酸共晶体表现为癌细胞生长抑制，并且当作为悬浮液施用时比相应的游离碱更具生物利用度。
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3.发明申请COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATION AND HYPERKERATOTIC LESIONS 审中-公开用于治疗炎症和高脂血症的组合物和方法公开(公告)号：US20110077297A1
公开(公告)日：2011-03-31
申请号：US12995116
申请日：2009-05-28
申请人： Burkhard Jansen
发明人： Burkhard Jansen
IPC分类号： A61K31/215 , A61P29/00 , A61P17/00 , A61P35/00 , A61P17/06
CPC分类号： A61K31/56 , A61K9/0014 , A61K47/10 , A61K47/26 , A61K47/44
摘要： A method of treating inflammation and hyperkeratotic lesions in a mammal in need thereof, by administering the following compound (NVX-207), a related compound, or a pharmaceutically acceptable salt thereof to the mammal.
摘要翻译： 通过向哺乳动物施用以下化合物（NVX-207），相关化合物或其药学上可接受的盐来治疗有需要的哺乳动物的炎症和角化过度损伤的方法。
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4.发明申请Betulin, betulin derivatives, betulinic acid and betulinic acid derivatives as novel therapeutics in the treatment of disease of lipid and/or glucose metabolism 审中-公开桦木醇，桦木酸衍生物，桦木酸和桦木酸衍生物作为治疗脂质和/或葡萄糖代谢疾病的新疗法公开(公告)号：US20060252733A1
公开(公告)日：2006-11-09
申请号：US11400779
申请日：2006-04-07
申请人： Burkhard Jansen
发明人： Burkhard Jansen
IPC分类号： A61K31/56
CPC分类号： A61K31/56
摘要： The invention relates to method of modulating lipid metabolism comprising contacting a cell with betulin, a betulin derivative, betulinic acid, a betulinic acid derivative, or a related steroid-like compound. In some aspects, the invention relates to the treatment of disorders of lipid metabolism. The invention further relates to methods of identifying compounds that modulate lipid metabolism. The invention also relates to the use of betulin, a betulin derivative, betulinic acid, a betulinic acid derivative, or a related steroid-like compound for preparation of a medicament for the treatment of a disorder of lipid metabolism.
摘要翻译： 本发明涉及调节脂质代谢的方法，包括使细胞与桦木醇，桦木醇衍生物，桦木酸，桦木酸衍生物或相关类固醇样化合物接触。 在一些方面，本发明涉及脂质代谢紊乱的治疗。 本发明还涉及鉴定调节脂质代谢的化合物的方法。 本发明还涉及桦木醇，桦木醇衍生物，桦木酸，桦木酸衍生物或相关类固醇样化合物在制备用于治疗脂质代谢紊乱的药物中的用途。
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公开(公告)号：US20060194774A1
公开(公告)日：2006-08-31
申请号：US10545143
申请日：2004-02-11
申请人： Edgar Selzer , Burkhard Jansen , Reinhard Paschke
发明人： Edgar Selzer , Burkhard Jansen , Reinhard Paschke
摘要： The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceuticals.
摘要翻译： 本发明涉及具有增加的用于治疗癌症和HIV疾病的活性的新型桦木酸衍生物，制备这种新型桦木酸衍生物的方法以及它们作为药物的用途。
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公开(公告)号：US07851462B2
公开(公告)日：2010-12-14
申请号：US11963505
申请日：2007-12-21
申请人： Edgar Selzer , Burkhard Jansen , Reinhard Paschke
发明人： Edgar Selzer , Burkhard Jansen , Reinhard Paschke
摘要： The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceuticals.
摘要翻译： 本发明涉及具有增加的用于治疗癌症和HIV疾病的活性的新型桦木酸衍生物，制备这种新型桦木酸衍生物的方法以及它们作为药物的用途。
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公开(公告)号：US20080214516A1
公开(公告)日：2008-09-04
申请号：US11963505
申请日：2007-12-21
申请人： Edgar Selzer , Burkhard Jansen , Reinhard Paschke
发明人： Edgar Selzer , Burkhard Jansen , Reinhard Paschke
摘要： The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceuticals.
摘要翻译： 本发明涉及具有增加的用于治疗癌症和HIV疾病的活性的新型桦木酸衍生物，制备这种新型桦木酸衍生物的方法以及它们作为药物的用途。
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公开(公告)号：US07312205B2
公开(公告)日：2007-12-25
申请号：US10545143
申请日：2004-02-11
申请人： Edgar Selzer , Burkhard Jansen , Reinhard Paschke
发明人： Edgar Selzer , Burkhard Jansen , Reinhard Paschke
摘要： The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceuticals.
摘要翻译： 本发明涉及具有增加的用于治疗癌症和HIV疾病的活性的新型桦木酸衍生物，制备这种新型桦木酸衍生物的方法以及它们作为药物的用途。
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