专利检索 ap:("Victor J Bauer" OR "Mike H O'Neill" OR "Barbara J Kidon" OR "Burkhard Jansen") AND inv:"Mike H O'Neill" 第 1 页

1.

发明授权
(Pyrroloquinoxalinyl) pyrazinecarbohydrazide-oxalic acid co-crystal for treatment of cancer and other diseases 有权
标题翻译：（吡咯喹喔啉基）吡嗪碳酰肼 - 草酸共晶，用于治疗癌症和其他疾病

公开(公告)号：US08058437B2

公开(公告)日：2011-11-15

申请号：US12937245

申请日：2009-04-08

申请人： Victor J Bauer , Mike H O'Neill , Barbara J Kidon , Burkhard Jansen

发明人： Victor J Bauer , Mike H O'Neill , Barbara J Kidon , Burkhard Jansen

IPC分类号： C07D241/42 , A61K31/498

CPC分类号： C07D487/04

摘要： A novel co-crystal of N′-(7-fluoropyrrolo[1,2a]quinoxalin-4-yl)pyrazine-2-carbohydrazide with oxalic acid is disclosed. The disclosed oxalic acid co-crystal demonstrates cancer cell growth inhibition and is more bioavailable than the corresponding free base when administered as a suspension.

摘要翻译： 公开了N' - （7-氟吡咯并[1,2a]喹喔啉-4-基）吡嗪-2-碳酰肼与草酸的新型共晶体。所公开的草酸共晶体表现为癌细胞生长抑制，并且当作为悬浮液施用时比相应的游离碱更具生物利用度。