公开(公告)号：US10525159B2

公开(公告)日：2020-01-07

申请号：US16304453

申请日：2016-05-26

申请人： OPHTECS CORPORATION

发明人： Katsuhide Yamazaki ,  Haruki Nakagawa

IPC分类号： A61L12/14

摘要： The present invention relates to a liquid preparation for soft contact lenses, particularly hydrogel contact lenses or silicone hydrogel contact lenses. The liquid preparation for contact lenses according to the present invention contains a hydrolyzed hyaluronic acid derivative having a monoether of a linear or branched alkyl group or alkenyl group having 6 or more and 20 or less carbon atoms and glycerol in a side chain. The liquid preparation for soft contact lenses according to the present invention may contain at least one cationic bactericide selected from the group consisting of an alexidine salt, a chlorhexidine salt, a polyhexamethylene biguanide salt and a quaternary ammonium salt. The liquid preparation for soft contact lenses according to the present invention is capable of suppressing adsorption of a cationic bactericide to soft contact lenses, and suppressing occurrence of corneal staining in a wearer.

公开(公告)号：US20100056631A1

公开(公告)日：2010-03-04

申请号：US12447413

申请日：2007-10-26

申请人： Ryuji Hisamura ,  Shigeru Nakamura ,  Toyoaki Yoneda

发明人： Ryuji Hisamura ,  Shigeru Nakamura ,  Toyoaki Yoneda

IPC分类号： A61K31/19 ,  C07C59/01 ,  A61P27/14

CPC分类号： A61K31/191 ,  A61K9/0048 ,  A61K31/19 ,  A61K49/0008

摘要： An antiallergenic composition comprising 3-hydroxybutyric acid and/or a salt thereof. The antiallergenic composition is safe.

摘要翻译： 包含3-羟基丁酸和/或其盐的抗过敏组合物。 抗过敏组合物安全。

公开(公告)号：US20070225369A1

公开(公告)日：2007-09-27

申请号：US10574615

申请日：2004-09-30

申请人： Yuzuru Umeda

发明人： Yuzuru Umeda

IPC分类号： A61K31/19

CPC分类号： A61K31/19 ,  A61K9/0048

摘要： There are provided an ophthalmic composition that comprises 3-hydroxybutyric acid and/or salts thereof as active ingredients and is used to prevent desiccation of eyes and an ophthalmic composition that is used to treat tear dysfunction. By use of the ophthalmic compositions of the present invention, desiccation of the eyes can be inhibited and tear dysfunction can be treated. Therefore, by use of the compositions, discomforts caused by tear dysfunction, such as desiccation of the eyes, foreign-body sensation, feeling of discomfort on the eyes and eye strain, can be improved. Further, the ophthalmic compositions of the present invention can inhibit diseases caused by tear dysfunction, exemplified by development of dry eye and suspected dry eye which are dysfunctions related to desiccation of the eyes, particularly, development of diseases caused by tear dysfunction without injuries on the keratoconjunctive.

摘要翻译： 提供了一种眼科组合物，其包含3-羟基丁酸和/或其盐作为活性成分，并用于防止眼睛干燥和用于治疗泪液功能障碍的眼用组合物。 通过使用本发明的眼用组合物，可以抑制眼睛的干燥并且可以治疗眼泪功能障碍。 因此，通过使用组合物，可以提高由泪液功能障碍引起的不适，例如眼睛干燥，异物感觉，眼睛不适感和眼睛疲劳感。 此外，本发明的眼用组合物可以抑制由泪液功能障碍引起的疾病，例如发展与眼睛干燥有关的功能障碍的干眼症和怀疑干眼症，特别是由泪液功能障碍引起的疾病的发展， 角膜结膜

公开(公告)号：US20190142990A1

公开(公告)日：2019-05-16

申请号：US16304453

申请日：2016-05-26

申请人： OPHTECS CORPORATION

发明人： Katsuhide Yamazaki ,  Haruki Nakagawa

IPC分类号： A61L12/14

摘要： The present invention relates to a liquid preparation for soft contact lenses, particularly hydrogel contact lenses or silicone hydrogel contact lenses. The liquid preparation for contact lenses according to the present invention contains a hydrolyzed hyaluronic acid derivative having a monoether of a linear or branched alkyl group or alkenyl group having 6 or more and 20 or less carbon atoms and glycerol in a side chain. The liquid preparation for soft contact lenses according to the present invention may contain at least one cationic bactericide selected from the group consisting of an alexidine salt, a chlorhexidine salt, a polyhexamethylene biguanide salt and a quaternary ammonium salt. The liquid preparation for soft contact lenses according to the present invention is capable of suppressing adsorption of a cationic bactericide to soft contact lenses, and suppressing occurrence of corneal staining in a wearer.

公开(公告)号：US08541468B2

公开(公告)日：2013-09-24

申请号：US10574615

申请日：2004-09-30

申请人： Yuzuru Umeda ,  Hideo Nakashima ,  Michiko Shibuya ,  Yasukazu Saitoh ,  Shoji Okada ,  Shigeru Nakamura

发明人： Yuzuru Umeda ,  Hideo Nakashima ,  Michiko Shibuya ,  Yasukazu Saitoh ,  Shoji Okada ,  Shigeru Nakamura

IPC分类号： A01N37/00

CPC分类号： A61K31/19 ,  A61K9/0048

摘要： There are provided an ophthalmic composition that comprises 3-hydroxybutyric acid and/or salts thereof as active ingredients and is used to prevent desiccation of eyes and an ophthalmic composition that is used to treat tear dysfunction. By use of the ophthalmic compositions of the present invention, desiccation of the eyes can be inhibited and tear dysfunction can be treated. Therefore, by use of the compositions, discomforts caused by tear dysfunction, such as desiccation of the eyes, foreign-body sensation, feeling of discomfort on the eyes and eye strain, can be improved. Further, the ophthalmic compositions of the present invention can inhibit diseases caused by tear dysfunction, exemplified by development of dry eye and suspected dry eye which are dysfunctions related to desiccation of the eyes, particularly, development of diseases caused by tear dysfunction without injuries on the keratoconjunctive.

摘要翻译： 提供了一种眼科组合物，其包含3-羟基丁酸和/或其盐作为活性成分，并用于防止眼睛干燥和用于治疗泪液功能障碍的眼用组合物。 通过使用本发明的眼用组合物，可以抑制眼睛的干燥并且可以治疗眼泪功能障碍。 因此，通过使用组合物，可以提高由泪液功能障碍引起的不适，例如眼睛干燥，异物感觉，眼睛不适感和眼睛疲劳感。 此外，本发明的眼用组合物可以抑制由泪液功能障碍引起的疾病，例如发展与眼睛干燥有关的功能障碍的干眼症和怀疑干眼症，特别是由泪液功能障碍引起的疾病的发展， 角膜结膜

公开(公告)号：US20130064873A1

公开(公告)日：2013-03-14

申请号：US13521412

申请日：2011-01-14

申请人： Kazuhiro Sasanuma ,  Kazuhiro Tone

发明人： Kazuhiro Sasanuma ,  Kazuhiro Tone

IPC分类号： A01N25/34 ,  A01P1/00 ,  A01N55/00

CPC分类号： A61L12/082 ,  A01N25/34 ,  A61L12/105 ,  C11D3/0042 ,  C11D3/0052 ,  C11D3/0078 ,  C11D3/046 ,  C11D3/10 ,  C11D3/2086 ,  C11D3/3707 ,  C11D3/485 ,  C11D17/0039 ,  C11D17/0078 ,  A01N59/12

摘要： An object of the present invention is to provide a nucleated tablet for contact lens (CL) cleaning that makes it possible to disinfect a CL simply and easily in the presence of a foaming component; a CL cleaning preparation that contains the nucleated tablet; and a method for cleaning a CL. The nucleated tablet for CL cleaning of the invention is a nucleated tablet including an outer shell that contains iodine-based bactericide, a carbonate, an organic acid, and a surfactant having, per partial weight of 2000 out of the molecular weight thereof, less than one hydroxyl group, and an inner nucleus that contains a neutralizing agent, a carbonate, an organic acid, and a surfactant, wherein the inner nucleus is coated for extended release.

摘要翻译： 本发明的目的是提供一种用于隐形眼镜（CL）清洁的成核片剂，其可以在发泡成分的存在下简单且容易地对CL进行消毒; 含有有核片的CL清洗剂; 以及清洁CL的方法。 用于本发明的CL清洗的成核片剂是包含含有碘类杀菌剂，碳酸盐，有机酸和表面活性剂的外壳的成核片剂，其分子量分子量为2000，分子量小于 一个羟基和含有中和剂，碳酸盐，有机酸和表面活性剂的内核，其中内核被涂覆以延长释放。