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26 条记录 (耗时 0.019 秒)

    Variant form of urate oxidase and use thereof
    1.
    发明授权
    Variant form of urate oxidase and use thereof 有权
    尿酸氧化酶的变体形式及其用途

    公开(公告)号：US08465735B2

    公开(公告)日：2013-06-18

    申请号：US13623512

    申请日：2012-09-20

    申请人： Savient Pharmaceuticals, Inc.

    发明人： Jacob Hartman ,  Simona Mendelovitz

    IPC分类号： A61K38/44

    CPC分类号： A61K38/44 ,  A61K47/60 ,  C12N9/0046 ,  C12Y107/03003

    摘要： The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.

    摘要翻译： 本发明涉及具有尿素分解活性的遗传修饰蛋白。 更具体地，本发明涉及包含截短的尿酸氧化酶的蛋白质及其制备方法，包括包含截短的尿酸氧化酶的聚乙二醇化蛋白质。

    VARIANT FORM OF URATE OXIDASE AND USE THEREOF
    2.
    发明申请
    VARIANT FORM OF URATE OXIDASE AND USE THEREOF 有权
    尿酸氧化酶的变化形式及其用途

    公开(公告)号：US20120225046A1

    公开(公告)日：2012-09-06

    申请号：US13452151

    申请日：2012-04-20

    申请人： Jacob Hartman ,  Simona Mendelovitz

    发明人： Jacob Hartman ,  Simona Mendelovitz

    IPC分类号： A61K38/44 ,  A61P3/00

    CPC分类号： A61K38/44 ,  A61K47/60 ,  C12N9/0046 ,  C12Y107/03003

    摘要： The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.

    摘要翻译： 本发明涉及具有尿素分解活性的遗传修饰蛋白。 更具体地，本发明涉及包含截短的尿酸氧化酶的蛋白质及其制备方法，包括包含截短的尿酸氧化酶的聚乙二醇化蛋白质。

    Use of oxandrolone in the treatment of burns and other wounds
    3.
    发明申请
    Use of oxandrolone in the treatment of burns and other wounds 失效
    用oxandrolone治疗烧伤和其他伤口

    公开(公告)号：US20040235940A1

    公开(公告)日：2004-11-25

    申请号：US10799264

    申请日：2004-03-12

    申请人： Savient Pharmaceuticals, Inc.

    发明人： Don Fishbein

    IPC分类号： A61K031/366

    CPC分类号： A61K31/366 ,  Y10S514/925 ,  Y10S514/928

    摘要： The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The invention also provides a method of treating a wound in a patient suffering from a wound which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The subject invention further provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone in conjunction with a protein supplement to the patient.

    摘要翻译： 本发明提供了一种治疗烧伤患者的烧伤引起的体重减轻的方法，其包括向患者施用治疗有效量的奥地罗尔酮。 本发明还提供了治疗患有伤口的患者中的伤口的方法，其包括向患者施用治疗有效量的奥地罗尔酮。 本发明进一步提供了一种治疗烧伤患者的烧伤引起的体重减轻的方法，该方法包括与患者的蛋白质补充剂一起施用治疗有效量的奥多罗酮。

    Use of oxandrolone in the treatment of burns and other wounds
    4.
    发明申请
    Use of oxandrolone in the treatment of burns and other wounds 失效

    公开(公告)号：US20040171673A1

    公开(公告)日：2004-09-02

    申请号：US10799197

    申请日：2004-03-12

    申请人： Savient Pharmaceuticals, Inc.

    发明人： Don Fishbein

    IPC分类号： A61K031/366

    CPC分类号： A61K31/366 ,  Y10S514/925 ,  Y10S514/928

    摘要： The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The invention also provides a method of treating a wound in a patient suffering from a wound which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The subject invention further provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone in conjunction with a protein supplement to the patient.

    Use Of Oxandrolone In The Treatment Of Burns And Other Wounds
    8.
    发明申请
    Use Of Oxandrolone In The Treatment Of Burns And Other Wounds 审中-公开
    在治疗烧伤和其他伤口中使用恶唑酮

    公开(公告)号：US20120015875A1

    公开(公告)日：2012-01-19

    申请号：US13242246

    申请日：2011-09-23

    申请人： Don Fishbein

    发明人： Don Fishbein

    IPC分类号： A61K38/02 ,  A61P3/00

    CPC分类号： A61K31/366 ,  Y10S514/925 ,  Y10S514/928

    摘要： The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The invention also provides a method of treating a wound in a patient suffering from a wound which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The subject invention further provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone in conjunction with a protein supplement to the patient.

    摘要翻译： 本发明提供了一种治疗烧伤患者的烧伤引起的体重减轻的方法，其包括向患者施用治疗有效量的奥地罗尔酮。 本发明还提供了治疗患有伤口的患者中的伤口的方法，其包括向患者施用治疗有效量的奥地罗尔酮。 本发明进一步提供了一种治疗烧伤患者的烧伤引起的体重减轻的方法，该方法包括与患者的蛋白质补充剂一起施用治疗有效量的奥多罗酮。

    Use of oxandrolone in the treatment of burns and other wounds
    9.
    发明授权
    Use of oxandrolone in the treatment of burns and other wounds 失效

    公开(公告)号：US08026274B2

    公开(公告)日：2011-09-27

    申请号：US10799197

    申请日：2004-03-12

    申请人： Don Fishbein

    发明人： Don Fishbein

    IPC分类号： A61K31/366

    CPC分类号： A61K31/366 ,  Y10S514/925 ,  Y10S514/928

    摘要： The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The invention also provides a method of treating a wound in a patient suffering from a wound which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The subject invention further provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone in conjunction with a protein supplement to the patient.

    VARIANT FORM OF URATE OXIDASE AND USE THEREOF
    10.
    发明申请
    VARIANT FORM OF URATE OXIDASE AND USE THEREOF 有权
    尿酸氧化酶的变化形式及其用途

    公开(公告)号：US20110217755A1

    公开(公告)日：2011-09-08

    申请号：US13107498

    申请日：2011-05-13

    申请人： Jacob Hartman ,  Simona Mendelovitz

    发明人： Jacob Hartman ,  Simona Mendelovitz

    IPC分类号： C12N9/06

    CPC分类号： A61K38/44 ,  A61K47/60 ,  C12N9/0046 ,  C12Y107/03003

    摘要： The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.

    摘要翻译： 本发明涉及具有尿素分解活性的遗传修饰蛋白。 更具体地，本发明涉及包含截短的尿酸氧化酶的蛋白质及其制备方法，包括包含截短的尿酸氧化酶的聚乙二醇化蛋白质。