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1.发明授权Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase 有权使用静脉注射PEG-尿酸酶降低尿酸水平的方法公开(公告)号：US08148123B2
公开(公告)日：2012-04-03
申请号：US11539475
申请日：2006-10-06
CPC分类号： A61K38/44 , A61K47/60 , C12Y107/03003
摘要： A method for lowering elevated uric acid levels in patients is disclosed and consists of administering to the patients an intravenous injection of PEG-uricase having a dosage from about 4 to about 12 mg.
摘要翻译： 公开了一种降低患者尿酸水平升高的方法，其中包括给患者静脉注射约4至约12mg剂量的PEG-尿酸酶。
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2.发明申请Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase 审中-公开使用静脉注射PEG-尿酸酶降低尿酸水平的方法公开(公告)号：US20080159976A1
公开(公告)日：2008-07-03
申请号：US11899688
申请日：2007-09-07
申请人： Jacob Hartman , Simona Mendelovitz , Claudia D. Rehrig , William Huang , Zebulun D. Horowitz , Royce W. Waltrip , David Erick Wright , Michelle A. Alton , Allan N. Maroli
发明人： Jacob Hartman , Simona Mendelovitz , Claudia D. Rehrig , William Huang , Zebulun D. Horowitz , Royce W. Waltrip , David Erick Wright , Michelle A. Alton , Allan N. Maroli
IPC分类号： A61K31/765 , A61P19/06
CPC分类号： A61K38/44 , A61K47/60 , C12Y107/03003
摘要： Disclosed is a method for lowering elevated uric acid levels in a patient having a plasma level of uric acid (pUAc) of more than about 6 mg/dL, the method consisting of administering to said patient an intravenous injections every 2 to 4 weeks of about 8 mg PEG-uricase.
摘要翻译： 公开了一种降低尿酸水平（pUAc）超过约6mg / dL的患者中升高的尿酸水平的方法，该方法包括给予所述患者每2-4周静脉内注射约 8毫克PEG-尿酸酶。
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3.发明申请Methods for Lowering Elevated Uric Acid Levels Using Intravenous Injections of PEG-Uricase 有权使用静脉注射PEG-Uricase降低尿酸水平升高的方法公开(公告)号：US20070274977A1
公开(公告)日：2007-11-29
申请号：US11539475
申请日：2006-10-06
CPC分类号： A61K38/44 , A61K47/60 , C12Y107/03003
摘要： A method for lowering elevated uric acid levels in patients is disclosed and consists of administering to the patients an intravenous injection of PEG-uricase having a dosage from about 4 to about 12 mg.
摘要翻译： 公开了一种降低患者尿酸水平升高的方法，其中包括给患者静脉注射约4至约12mg剂量的PEG-尿酸酶。
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公开(公告)号：US20120225046A1
公开(公告)日：2012-09-06
申请号：US13452151
申请日：2012-04-20
申请人： Jacob Hartman , Simona Mendelovitz
发明人： Jacob Hartman , Simona Mendelovitz
CPC分类号： A61K38/44 , A61K47/60 , C12N9/0046 , C12Y107/03003
摘要： The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.
摘要翻译： 本发明涉及具有尿素分解活性的遗传修饰蛋白。 更具体地，本发明涉及包含截短的尿酸氧化酶的蛋白质及其制备方法，包括包含截短的尿酸氧化酶的聚乙二醇化蛋白质。
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公开(公告)号：US08541205B2
公开(公告)日：2013-09-24
申请号：US13461170
申请日：2012-05-01
申请人： Jacob Hartman , Simona Mendelovitz
发明人： Jacob Hartman , Simona Mendelovitz
CPC分类号： C12N9/0048 , A61K38/44 , A61K47/48215 , A61K47/60 , C12N9/0046 , C12Y107/03003
摘要： Genetically modified proteins with uricolytic activity are described. Proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidase are described.
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公开(公告)号：US08293228B2
公开(公告)日：2012-10-23
申请号：US13452151
申请日：2012-04-20
申请人： Jacob Hartman , Simona Mendelovitz
发明人： Jacob Hartman , Simona Mendelovitz
CPC分类号： A61K38/44 , A61K47/60 , C12N9/0046 , C12Y107/03003
摘要： The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.
摘要翻译： 本发明涉及具有尿素分解活性的遗传修饰蛋白。 更具体地，本发明涉及包含截短的尿酸氧化酶的蛋白质及其制备方法，包括包含截短的尿酸氧化酶的聚乙二醇化蛋白质。
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公开(公告)号：US08178334B2
公开(公告)日：2012-05-15
申请号：US13226891
申请日：2011-09-07
申请人： Jacob Hartman , Simona Mendelovitz
发明人： Jacob Hartman , Simona Mendelovitz
CPC分类号： A61K38/44 , A61K47/60 , C12N9/0046 , C12Y107/03003
摘要： The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.
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公开(公告)号：US07964381B2
公开(公告)日：2011-06-21
申请号：US12879084
申请日：2010-09-10
申请人： Jacob Hartman , Simona Mendelovitz
发明人： Jacob Hartman , Simona Mendelovitz
CPC分类号： A61K38/44 , A61K47/60 , C12N9/0046 , C12Y107/03003
摘要： The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.
摘要翻译： 本发明涉及具有尿素分解活性的遗传修饰蛋白。 更具体地，本发明涉及包含截短的尿酸氧化酶的蛋白质及其制备方法，包括包含截短的尿酸氧化酶的聚乙二醇化蛋白质。
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公开(公告)号：US20120070876A1
公开(公告)日：2012-03-22
申请号：US13226891
申请日：2011-09-07
申请人： Jacob Hartman , Simona Mendelovitz
发明人： Jacob Hartman , Simona Mendelovitz
CPC分类号： A61K38/44 , A61K47/60 , C12N9/0046 , C12Y107/03003
摘要： The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.
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公开(公告)号：US20110217755A1
公开(公告)日：2011-09-08
申请号：US13107498
申请日：2011-05-13
申请人： Jacob Hartman , Simona Mendelovitz
发明人： Jacob Hartman , Simona Mendelovitz
IPC分类号： C12N9/06
CPC分类号： A61K38/44 , A61K47/60 , C12N9/0046 , C12Y107/03003
摘要： The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.
摘要翻译： 本发明涉及具有尿素分解活性的遗传修饰蛋白。 更具体地，本发明涉及包含截短的尿酸氧化酶的蛋白质及其制备方法，包括包含截短的尿酸氧化酶的聚乙二醇化蛋白质。
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