公开(公告)号：US20160137640A1

公开(公告)日：2016-05-19

申请号：US14895832

申请日：2014-06-18

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES ,  SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD.

发明人： Jingkang Shen ,  Meiyu Geng ,  Jian Ding ,  Bing Xiong ,  Jing Al ,  Yuchi Ma ,  Xin Wang ,  Xia Peng ,  Yuelei Chen ,  Danqi Chen ,  Tao Meng ,  Lanping Ma ,  Yinchun Ji

IPC分类号： C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D519/00

摘要： This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of producing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumours associated with abnormal protein tyrosine kinase.

摘要翻译： 本发明提供一类如下式（X）所示的五元杂环稠合吡啶化合物，其药学上可接受的盐或药学上可接受的溶剂合物，其制备方法，含该化合物的药物组合物，以及该化合物的用途 在制备用于预防和/或治疗与异常蛋白酪氨酸激酶相关的疾病和肿瘤的药物中。

公开(公告)号：US20220273598A1

公开(公告)日：2022-09-01

申请号：US17631804

申请日：2020-08-05

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. ,  SHANGAHI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Guangqiang Sun ,  Xinyi Wang ,  Jing Zhang ,  Teng Feng

IPC分类号： A61K31/198 ,  A61K31/437 ,  A61K31/702 ,  A61P25/28 ,  G01N33/483 ,  G01N33/50 ,  G01N33/68

摘要： Provided is the use of a reagent for inhibiting the uptake of amino acids by naive T cells in the preparation of a drug for treating Alzheimer's disease in a subject.

公开(公告)号：US20210322449A1

公开(公告)日：2021-10-21

申请号：US17256889

申请日：2019-06-28

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/702 ,  A61K31/7012 ,  A61K31/7016 ,  A61K31/715 ,  A61P3/10

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of diabetes.

公开(公告)号：US20200055888A1

公开(公告)日：2020-02-20

申请号：US16325961

申请日：2016-08-15

申请人： Shanghai Green Valley Pharmaceutical Co., LTD.

发明人： Zhongping Xiao ,  Zhenqing Zhang ,  Meiyu Geng ,  Jian Ding

IPC分类号： C07H7/033 ,  C07H1/00

摘要： The invention relates to a new method of preparing oligomannuronic diacids, important bioactives. The method utilizes oligomannuronic acids as starting materials and the target substances are obtained by acid degradation and active hypobromous acid oxidation steps. The method of preparing oligomannuronic diacids according to the invention employs moderate reaction conditions, has few side reactions, does not need further purification, achieves a yield of more than 90%, or even more than 95%, and is suitable for production with an on-line continuous reactor device, with reaction processes easy to implement automatic control.

公开(公告)号：US20220362271A1

公开(公告)日：2022-11-17

申请号：US17631731

申请日：2020-08-05

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Guangqiang Sun ,  Xinyi Wang ,  Jing Zhang ,  Teng Feng

IPC分类号： A61K31/702 ,  A61K31/734 ,  A61P19/02 ,  A61P25/28 ,  A61P5/16 ,  A61P5/50

摘要： A use that relates to mannuronic acid oligosaccharides or a composition comprising same in the treatment of Th1-dominance related diseases. The Th1-dominance related diseases may be selected from Multiple Sclerosis, Crohn's disease, Type I Diabetes, Rheumatoid Arthritis, Hashimoto's thyroiditis, vitiligo, Sjögren's Syndrome, Polycystic ovary syndrome, Celiac Disease and Grave's disease, preferably from Multiple Sclerosis, Crohn's disease and Rheumatoid Arthritis.

公开(公告)号：US11366086B2

公开(公告)日：2022-06-21

申请号：US16763139

申请日：2018-09-06

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. ,  SOOCHOW UNIVERSITY

发明人： Zhenqing Zhang ,  Yangyang Zeng

IPC分类号： G01N30/88 ,  G01N21/73 ,  G01N30/74

摘要： The invention belongs to the technical field of natural medicinal chemistry and quality control thereof, and relates to a method for determining the weight average molecular weight and the purity of a soluble salt of an acidic saccharide. The method comprises using metal ion content in the soluble salt of an acidic saccharide to correct the weight average molecular weight and the content of the of acid saccharide obtained by the combined use of the molecular sieve chromatography and a multi-angle laser scattering detector SEC-MALS. The method of the present invention can be used to more quickly and accurately determine the weight average molecular weight and content of acidic saccharide soluble salts.

公开(公告)号：US20210268006A1

公开(公告)日：2021-09-02

申请号：US17256738

申请日：2019-06-28

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Xiaoguang Du ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/702 ,  A61P25/28

摘要： The present invention relates to the application of mannuronic diacid oligosaccharide composition in the treatment of vascular dementia.

公开(公告)号：US20210260089A1

公开(公告)日：2021-08-26

申请号：US17256807

申请日：2019-06-28

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Xiaoguang Du ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/7032 ,  A61K31/716 ,  A61P25/16

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of Parkinson's disease.

公开(公告)号：US20200376021A1

公开(公告)日：2020-12-03

申请号：US16967391

申请日：2019-02-02

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. ,  SOOCHOW UNIVERSITY

发明人： Zhenqing Zhang ,  Naiyu Xu ,  Xiang Yin ,  Li Pang ,  Lulu Shen ,  Jie Xue

IPC分类号： A61K31/715 ,  A61P3/06

摘要： Provided herein are an isolated Imperata cylindrica polysaccharide and use thereof in the manufacture of a medicament for treating hyperlipoidemia. The Imperata cylindrica polysaccharide comprises L-arabinose, D-xylose, D-mannose, D-glucose and D-galactose, wherein the molar ratio of the L-arabinose:D-xylose:D-mannose:D-glucose:D-galactose is 1-20:1-15:1-15:15-40:25-60.

公开(公告)号：US20180207195A1

公开(公告)日：2018-07-26

申请号：US15576477

申请日：2016-05-20

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD.

发明人： Zhenqing ZHANG ,  Jie HAO ,  Shichang SUN ,  Huiling ZHANG

IPC分类号： A61K31/715 ,  C07H7/033 ,  A61P9/10 ,  A61P25/00

CPC分类号： A61K31/715 ,  A61P9/10 ,  A61P25/00 ,  C07C31/04 ,  C07C31/08 ,  C07H1/00 ,  C07H7/033 ,  C07H15/04 ,  C08B31/18 ,  C08L3/10

摘要： An oxidized α-1,4-oligoglucuronic acid, and a preparation method therefor and uses thereof. By using abundant starch, especially soluble starch, in the natural world as the raw material, all 6-site hydroxyl groups of the starch α-1,4-polyglucose are oxidized into carboxyl groups to form glucuronic acid under the action of a sodium bromide (NaBr)-2,2,6,6-tetramethyl piperidine oxide (TEMPO)-sodium hypochlorite (NaClO) oxidation system, and the oxidized oligoglucuronic acid having an open ring at an end is prepared by controlling reaction conditions. The compound has obvious anti-cerebral ischemia activity, and can be developed into a potential anti-cerebral ischemia drug.