公开(公告)号：US20080287397A1

公开(公告)日：2008-11-20

申请号：US12106873

申请日：2008-04-21

申请人： Atsuro NAKAZATO ,  Taketoshi Okubo ,  Dai Nozawa ,  Mikako Yamaguchi ,  Tomoko Tamita ,  Ludo E.J. Kennis ,  Marcel F.L. De Bruyn ,  Jean-Pierre A.M. Bongartz ,  Frans M.A. Van Den Keybus ,  Yves E.M. Van Roosbroeck ,  Marcel G.M. Luyckx ,  Robert J.M. Hendrickx

发明人： Atsuro NAKAZATO ,  Taketoshi Okubo ,  Dai Nozawa ,  Mikako Yamaguchi ,  Tomoko Tamita ,  Ludo E.J. Kennis ,  Marcel F.L. De Bruyn ,  Jean-Pierre A.M. Bongartz ,  Frans M.A. Van Den Keybus ,  Yves E.M. Van Roosbroeck ,  Marcel G.M. Luyckx ,  Robert J.M. Hendrickx

IPC分类号： A61K31/661 ,  C07D487/04 ,  A61P25/00 ,  A61P17/00 ,  A61P1/00 ,  A61P29/00 ,  A61K31/519

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07F9/6561

摘要： An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. This problem can be solved with a pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by formula [I] below which has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

摘要翻译： 本发明的目的是提供一种抗CRF受体的拮抗剂，其作为治疗或预防药物是有效的，其涉及CRF被认为涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食 疾病，高血压，胃疾病，药物依赖，癫痫，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，脱发，肠易激综合征，睡眠障碍，癫痫，皮肤病，精神分裂症等。 可以用由以下式[I]表示的环氨基取代的吡咯并嘧啶或吡咯并吡啶衍生物来解决问题，其具有对CRF受体的高亲和力，并且对于CRF被认为涉及的疾病是有效的。