利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

29 条记录 (耗时 0.013 秒)

    Derivatives of cholest-4-en-3-one oxime, pharmaceutical compositions containing them and preparation method
    2.
    发明授权
    Derivatives of cholest-4-en-3-one oxime, pharmaceutical compositions containing them and preparation method 有权
    胆甾-4-烯-3-酮肟的衍生物，含有它们的药物组合物及其制备方法

    公开(公告)号：US08481515B2

    公开(公告)日：2013-07-09

    申请号：US12158640

    申请日：2006-12-15

    申请人： Cyrille Drouot ,  Delphine Maux

    发明人： Cyrille Drouot ,  Delphine Maux

    IPC分类号： A61K31/575 ,  C07J41/00

    CPC分类号： C07J41/0016

    摘要： The object of the invention is the use as a drug of a compound fitting formula I wherein X represents an oxygen atom or a ═N—OH group and R represents a group selected from or one of its esters and/or of its addition salts with pharmaceutically acceptable acids, particularly as a cytoprotective drug, preferentially a cardioprotective and/or neuroprotective drug, the compounds of formula I wherein R is R2, R3, R4, R5 or R6 as novel compounds as well as their preparation method and use.

    摘要翻译： 本发明的目的是用作化合物配方I的药物的用途，其中X表示氧原子或= N-OH基团，R表示选自其酯和/或其加成盐中的一种或其加成盐的基团， 药学上可接受的酸，特别是细胞保护性药物，优选心脏保护和/或神经保护药物，式I化合物，其中R是R2，R3，R4，R5或R6作为新化合物及其制备方法和用途。

    Use as medicaments of derivatives of cholest-4-en-3-one, pharmaceutical compositions containing them, novel derivatives and their preparation process
    3.
    发明授权
    Use as medicaments of derivatives of cholest-4-en-3-one, pharmaceutical compositions containing them, novel derivatives and their preparation process 有权
    用作胆固醇-4-烯-3-酮衍生物的药物，含有它们的药物组合物，新型衍生物及其制备方法

    公开(公告)号：US08283341B2

    公开(公告)日：2012-10-09

    申请号：US12776217

    申请日：2010-05-07

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/375 ,  C07J9/00 ,  C07J41/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ═N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICINE
    4.
    发明申请
    NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICINE 失效
    新化学化合物及其作为医药的用途

    公开(公告)号：US20090203747A1

    公开(公告)日：2009-08-13

    申请号：US11994354

    申请日：2006-06-29

    申请人： Corinne Chaimbault ,  Cyrille Drouot ,  Laure Jamot ,  Rebecca Pruss ,  Celine Simon

    发明人： Corinne Chaimbault ,  Cyrille Drouot ,  Laure Jamot ,  Rebecca Pruss ,  Celine Simon

    IPC分类号： A61K31/426 ,  C07D277/38 ,  C07D401/02 ,  C07C337/08 ,  A61K31/437 ,  A61P25/00

    CPC分类号： C07D277/50

    摘要： The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated.Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products.The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.

    摘要翻译： 本发明涉及药学领域，特别是治疗神经变性疾病。 本发明具体涉及已经证明了神经保护活性的化合物族。 鉴于所述家族的某些成员是未经描述的新化合物，本发明涉及所述新产品，其合成方法和某些新型中间体合成产品。 本发明还涉及包含所述家族化合物的组合物和所述化合物作为药物的用途，特别是用于制备用于治疗神经变性疾病的药物。

    Method for providing neuroprotection from spinal muscular atrophy
    5.
    发明授权
    Method for providing neuroprotection from spinal muscular atrophy 有权
    从脊髓性肌萎缩提供神经保护的方法

    公开(公告)号：US08354395B2

    公开(公告)日：2013-01-15

    申请号：US13591789

    申请日：2012-08-22

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/375 ,  C07J9/00 ,  C07J41/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ═N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    Device for sequential observation of samples and methods using same
    6.
    发明授权
    Device for sequential observation of samples and methods using same 有权
    用于顺序观察样品的装置和使用其的方法

    公开(公告)号：US07372626B2

    公开(公告)日：2008-05-13

    申请号：US10276245

    申请日：2001-05-10

    申请人： Pascal Villa ,  Michel Delaage ,  Toni Williamson

    发明人： Pascal Villa ,  Michel Delaage ,  Toni Williamson

    IPC分类号： G02B21/26

    CPC分类号： G02B21/241 ,  G02B21/26

    摘要： The invention concerns methods and devices for observing or analysing samples on a support. More particularly, it concerns a device for sequential observation of several samples arranged on a common plate (19) comprising an objective (15) for observing a stage (17) for positioning the plate (19) adapted to ensure a relative displacement between the plate (19) and the observation axis in a plane perpendicular to the observation axis, while leaving free the vertical displacement along the observation axis, means (21) for illuminating the sample and means (23, 25) for acquiring an image at the objective (15) output. It comprises a spacer (43) fixed relative to the objective (15) and having a support surface (45) on the support (19), said support surface being located proximate to the observation axis, so that said spacer (43) is adapted to maintain, on the observation axis, a constant distance between the objective (15) and the observation surface (29), during a relative displacement between the support (19) and the observation axis. The invention is useful for rapid analysis of cell samples.

    摘要翻译： 本发明涉及用于观察或分析支持物上的样品的方法和装置。 更具体地说，它涉及用于顺序观察布置在公共板（19）上的几个样品的装置，其包括用于观察用于定位板（19）的台（17）的物镜（15），所述台（17）适于确保板 （19）和垂直于观察轴的平面中的观察轴，同时沿着观察轴线释放垂直位移，用于照亮样本的装置（21）和用于获取物镜上的图像的装置（23,25） 15）输出。 它包括相对于物镜（15）固定并且在支撑件（19）上具有支撑表面（45）的间隔件（43），所述支撑表面位于观察轴线附近，使得所述间隔物（43）适于 在支撑件（19）和观察轴线之间的相对位移期间，在观察轴线上保持物镜（15）和观察表面（29）之间的恒定距离。 本发明可用于细胞样品的快速分析。

    Device for positioning a plate used for analyzing samples on an examination device
    8.
    发明授权
    Device for positioning a plate used for analyzing samples on an examination device 失效
    用于定位用于在检查装置上分析样品的板的装置

    公开(公告)号：US07072105B2

    公开(公告)日：2006-07-04

    申请号：US10501233

    申请日：2003-01-09

    申请人： Michel Delaage

    发明人： Michel Delaage

    IPC分类号： G02B21/26

    CPC分类号： G02B21/26

    摘要： The invention relates to a device for positioning a biological sample analysis plate on an observation device comprising an observation lens and a chassis having a plate support assembly [20]. This assembly comprises a first frame [21] and a second frame [22] able to slide in a plane perpendicular to the observation axis, assumed to be vertical, with the first and second frames each able to move in a direction perpendicular to the direction of movement of the other frame; and a third frame [23] supported by the second frame [22] by means [30] used to maintain said third frame in a plane perpendicular to the observation axis, while leaving the movement free in a vertical plane.

    摘要翻译： 本发明涉及一种用于将生物样品分析板定位在观察装置上的装置，包括观察透镜和具有板支撑组件的底架[20]。 该组件包括第一框架[21]和第二框架[22]，其能够垂直于观察轴线的平面滑动，假设为垂直的，第一和第二框架每个都能够沿垂直于该方向的方向移动 的另一个框架的运动; 以及第三框架[23]，其由用于将所述第三框架保持在垂直于观察轴线的平面中的装置[30]支撑，同时使移动在垂直平面中自由。

    Chemical compounds and the uses thereof as a medicine
    9.
    发明授权
    Chemical compounds and the uses thereof as a medicine 失效
    化合物及其作为药物的用途

    公开(公告)号：US08691854B2

    公开(公告)日：2014-04-08

    申请号：US11994354

    申请日：2006-06-29

    申请人： Corinne Chaimbault ,  Cyrille Drouot ,  Laure Jamot ,  Rebecca Pruss ,  Céline Simon

    发明人： Corinne Chaimbault ,  Cyrille Drouot ,  Laure Jamot ,  Rebecca Pruss ,  Céline Simon

    IPC分类号： A01N43/78 ,  A61K31/425 ,  C07D277/00 ,  C07D327/04 ,  C07D343/00

    CPC分类号： C07D277/50

    摘要： The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated.Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products.The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.

    摘要翻译： 本发明涉及药学领域，特别是治疗神经变性疾病。 本发明具体涉及已经证明了神经保护活性的化合物族。 鉴于所述家族的某些成员是未经描述的新化合物，本发明涉及所述新产品，其合成方法和某些新型中间体合成产品。 本发明还涉及包含所述家族化合物的组合物和所述化合物作为药物的用途，特别是用于制备用于治疗神经变性疾病的药物。