公开(公告)号：US20240238244A1

公开(公告)日：2024-07-18

申请号：US18558870

申请日：2022-05-05

申请人： 4LIVING BIOTECH ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT PASTEUR DE LILLE ,  UNIVERSITE DE LILLE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

发明人： Revital RATTENBACH ,  Keren BISMUTH ,  Jérome BRETON ,  François TROTTEIN ,  Valentin SENCIO

IPC分类号： A61K31/395 ,  A61K45/06 ,  A61P31/16

CPC分类号： A61K31/395 ,  A61K45/06 ,  A61P31/16

摘要： A compound of formula (I) or a pharmaceutically acceptable salt and/or hydrate thereof, for use in the treatment of a viral pulmonary disease or a chronic respiratory distress syndrome (CRDS) resulting from a viral pulmonary disease in a subject, the disease being different from COVID-19, wherein formula (I) is Z—R-A-R′—Y, including plerixafor.

公开(公告)号：US20230157994A1

公开(公告)日：2023-05-25

申请号：US17922865

申请日：2021-05-05

申请人： 4LIVING BIOTECH ,  UNIVERSITE DE BORDEAUX ,  CENTRE HOSPITALIER DE BORDEAUX ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM ,  INSTITUT PASTEUR DE LILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITÉ DE LILLE

发明人： Patrick BERGER ,  Isabelle DUPIN ,  Renaud PREVEL ,  Chloé JAMES ,  Pierre-Olivier GIRODET ,  Keren BISMUTH ,  Revital RATTENBACH ,  Jérôme BRETON ,  Francois TROTTEIN ,  Valentin SENCIO

IPC分类号： A61K31/395 ,  A61K31/662 ,  A61K45/06 ,  A61P31/14

CPC分类号： A61K31/395 ,  A61K31/662 ,  A61K45/06 ,  A61P31/14

摘要： A method of treating COVID-19 in a patient. The patient may be in moderate to advanced stages of COVID-19 infection. The method includes administering to the patient a therapeutically effective amount of at least one antagonist or inhibitor of chemokine receptor CXCR4. The at least one antagonist or inhibitor of chemokine receptor CXCR4 is distinct from hydroxychloroquine.