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    Process for the racemization of α-amino acids
    5.
    发明授权
    Process for the racemization of α-amino acids 有权

    公开(公告)号：US09598353B2

    公开(公告)日：2017-03-21

    申请号：US14913979

    申请日：2014-08-07

    申请人： Aminologics Co., Ltd.

    发明人： Il Suk Byun ,  Kyu Sung Han ,  Hye Rim Ga

    IPC分类号： C07C227/36 ,  B01J31/22

    CPC分类号： C07C227/36 ,  B01J31/0239 ,  B01J31/1805 ,  B01J31/2243 ,  B01J31/2295 ,  B01J2231/50 ,  B01J2531/16

    摘要： According to the present invention, a method is provided wherein a basic aqueous phase containing an optically active α-amino acid is brought into contact with an organic phase containing a racemisation catalyst in the form of a copper metal complex of copper ions and an α-amino acid and salicylaldehyde, in the presence of a phase transition catalyst, thereby subjecting the optically active α-amino acid to racemisation. In the α-amino acid racemisation method according to the present invention, the reaction conditions are mild and thus there is little α-amino acid breakdown and the yield is high, the racemisation catalyst can be reused, the α-amino acid resulting from the racemisation can easily be isolated and purified, and the racemisation method can be implemented in volume such that the invention is economic.

    t-Butylketone Binaphthol Derivative And Method Of Preparing The Same
    6.
    发明申请
    t-Butylketone Binaphthol Derivative And Method Of Preparing The Same 有权
    叔丁基联萘酚衍生物及其制备方法

    公开(公告)号：US20170050923A1

    公开(公告)日：2017-02-23

    申请号：US15119874

    申请日：2015-02-17

    申请人： EWHA UNIVERSITY- INDUSTRY COLLABORATION FOUNDATION ,  AMINOLOGICS CO., LTD

    发明人： Kwan Mook Kim ,  Haofei Huang

    IPC分类号： C07C275/32

    CPC分类号： C07C275/32 ,  C07B2200/07

    摘要： The present disclosure relates to a t-butylketone binaphthol derivative and a method of preparing the same, the t-butylketone binaphthol derivative being a high-efficiency chiral extracting agent which has a very high chiral selectivity enabling to extract an amino acid from an aqueous solution phase to an organic layer and to facilitate its hydrolysis, and enabling a continuous reuse of the organic layer.

    摘要翻译： 本公开内容涉及叔丁基酮联萘酚衍生物及其制备方法，所述叔丁基酮联萘酚衍生物是高效手性提取剂，其具有非常高的手性选择性，从而能够从水溶液中提取氨基酸 相转化为有机层并促进其水解，并且能够连续地再利用有机层。

    PROCESS FOR THE RACEMIZATION OF ALPHA-AMINO ACIDS
    7.
    发明申请
    PROCESS FOR THE RACEMIZATION OF ALPHA-AMINO ACIDS 有权
    α-氨基酸酸化反应的方法

    公开(公告)号：US20160221929A1

    公开(公告)日：2016-08-04

    申请号：US14913979

    申请日：2014-08-07

    申请人： AMINOLOGICS CO., LTD.

    发明人： Il Suk BYUN ,  Kyu Sung HAN ,  Hye Rim GA

    IPC分类号： C07C227/36 ,  B01J31/22

    CPC分类号： C07C227/36 ,  B01J31/0239 ,  B01J31/1805 ,  B01J31/2243 ,  B01J31/2295 ,  B01J2231/50 ,  B01J2531/16

    摘要： According to the present invention, a method is provided wherein a basic aqueous phase containing an optically active α-amino acid is brought into contact with an organic phase containing a racemisation catalyst in the form of a copper metal complex of copper ions and an α-amino acid and salicylaldehyde, in the presence of a phase transition catalyst, thereby subjecting the optically active α-amino acid to racemisation. In the α-amino acid racemisation method according to the present invention, the reaction conditions are mild and thus there is little α-amino acid breakdown and the yield is high, the racemisation catalyst can be reused, the α-amino acid resulting from the racemisation can easily be isolated and purified, and the racemisation method can be implemented in volume such that the invention is economic.

    摘要翻译： 根据本发明，提供一种方法，其中使含有光学活性α-氨基酸的碱性水相与含有铜离子和α-氧化物的铜金属络合物形式的外消旋催化剂的有机相接触， 氨基酸和水杨醛，在相变催化剂的存在下，使光学活性α-氨基酸进行外消旋化。 在根据本发明的α-氨基酸外消旋化方法中，反应条件温和，因此几乎没有α-氨基酸分解，产率高，外消旋催化剂可以重复使用，由α- 可以容易地分离和纯化外消旋化，并且外消旋化方法可以体积实施，使得本发明是经济的。