公开(公告)号：US20250161647A1

公开(公告)日：2025-05-22

申请号：US18863666

申请日：2023-03-14

Applicant: ANHUI UNIVERSITY OF CHINESE MEDICINE ,  ANHUI BAICAOJINGYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.

Inventor： Can PENG ,  Huanhuan LIU ,  Suping JIANG ,  Jiming KE ,  Jing ZHANG ,  Chijing ZUO ,  Cancan FANG ,  Shuangying GUI ,  Daiyin PENG

IPC: A61M37/00 ,  B29C35/08 ,  B29C37/00 ,  B29C41/04

Abstract: A preparation method of a colchicine (COL) hydrogel microneedle (MN) is provided, including the following steps: dissolving an acrylamide (AM), N,N′-bis(acryloyl) cysteamine (BACA), and Irgacure 2959 in ultrapure water to obtain a clear gel solution; pouring the clear gel solution into a polydimethylsiloxane (PDMS) mold, conducting low-speed centrifugation, and conducting an ultrasonic treatment to eliminate air bubbles; irradiating the PDMS mold under ultraviolet light, and air-drying in an oven to obtain a hydrogel MN; and adding a COL solution to the hydrogel MN, allowing swelling, air-drying, and demolding. The present disclosure overcomes the shortcoming that cross-linking points are unevenly distributed in the ordinary hydrogel MNs. The hydrogel MN prepared by the present disclosure has a complete needle shape, a neat matrix arrangement, cross-linking points evenly distributed in a network, and excellent mechanical toughness and a superior swelling capacity.