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18 条记录 (耗时 0.022 秒)

    CRYSTALLINE FORMS OF A RYANODINE RECEPTOR MODULATOR AND USES THEREOF
    8.
    发明申请
    CRYSTALLINE FORMS OF A RYANODINE RECEPTOR MODULATOR AND USES THEREOF 有权

    公开(公告)号：US20220226344A1

    公开(公告)日：2022-07-21

    申请号：US17571038

    申请日：2022-01-07

    申请人： ARMGO Pharma, Inc.

    发明人： Pascal TAULELLE ,  Sandro BELVEDERE

    IPC分类号： A61K31/554

    摘要： The present disclosure relates to crystalline forms of the compound 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)yl)methyl]benzoic acid hemifumarate, pharmaceutical compositions comprising these compounds and uses thereof to treat diseases and conditions associated with Ryanodine Receptor (RyR) dysfunction, in particular cardiac and musculoskeletal disorders and diseases.

    Process for preparing benzothiazepines from gamma-aminoalkylbenzenes
    9.
    发明授权
    Process for preparing benzothiazepines from gamma-aminoalkylbenzenes 有权
    从γ-氨基烷基苯制备苯并硫氮杂的方法

    公开(公告)号：US09573914B2

    公开(公告)日：2017-02-21

    申请号：US14138893

    申请日：2013-12-23

    申请人： LES LABORATOIRES SERVIER ,  ARMGO PHARMA, INC.

    发明人： Shixian Deng ,  Sandro Belvedere ,  Jiaming Yan ,  Donald Landry

    IPC分类号： A61K31/554 ,  C07D513/04 ,  C07D281/02 ,  C07D281/10

    CPC分类号： C07D281/02 ,  C07D281/10 ,  C07D513/04 ,  Y02P20/55

    摘要： The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula: by reacting a [2-(acylaminoethyl)thio]arene of formula with an aldehyde or a multimer thereof, and with an acid. The invention also provides for first reacting the [2-(acylaminoethyl)thio]arene with the aldehyde or multimer thereof and a base to form an [N-hydroxymethyl-2-[acylaminoethyl)thio]arene of formula then treating the [N-hydroxymethyl-2-(acylaminoethyl)thio]arene with the acid to form the 2,3,4,5-tetrahydro[1,4]benzothiazepine.

    摘要翻译： 本发明提供了制备下式的2,3,4,5-四氢[1,4]苯并硫氮杂的方法：通过使式的[2-（酰基氨基乙基）硫代]芳烃或其多聚体与 酸。 本发明还提供了使[2-（酰基氨基乙基）硫代]芳烃与其醛或多聚体和碱反应以形成式的[N-羟甲基-2- [酰氨基乙基]硫代]芳烃，然后将[N- 羟基甲基-2-（酰氨基乙基）硫代]芳烃与酸形成2,3,4,5-四氢[1,4]苯并硫氮杂。

    PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES
    10.
    发明申请
    PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES 有权
    从氨基 - 氨基苯甲腈制备苯并噻唑的方法

    公开(公告)号：US20140121368A1

    公开(公告)日：2014-05-01

    申请号：US14138893

    申请日：2013-12-23

    申请人： ARMGO PHARMA, INC. ,  LES LABORATOIRES SERVIER

    发明人： Shixian DENG ,  Sandro BELVEDERE ,  Jiaming YAN ,  Donald LANDRY

    IPC分类号： C07D281/02

    CPC分类号： C07D281/02 ,  C07D281/10 ,  C07D513/04 ,  Y02P20/55

    摘要： The invention provides a process for preparing a 2,3,4,5-tetrahydro[1.4]benzothiazepine of formula: by reacting a [2-(acylaminoethyl)thio]arene of formula with an aldehyde or a multimer thereof, and with an acid. The invention also provides for first reacting the [2-(acylaminoethyl)thio]arene with the aldehyde or multimer thereof and a base to form an [N-hydroxymethyl-2-[acylaminoethyl)thio]arene of formula then treating the [N-hydroxymethyl-2-(acylaminoethyl)thio]arene with the acid to form the 2,3,4,5-tetrahydro[1,4]benzothiazepine.

    摘要翻译： 本发明提供了一种制备下式的2,3,4,5-四氢[1,4]苯并硫氮杂的方法：通过使式的[2-（酰基氨基乙基）硫代]芳烃与醛或其多聚体和酸 。 本发明还提供了使[2-（酰基氨基乙基）硫代]芳烃与其醛或多聚体和碱反应以形成式的[N-羟甲基-2- [酰氨基乙基]硫代]芳烃，然后将[N- 羟基甲基-2-（酰氨基乙基）硫代]芳烃与酸形成2,3,4,5-四氢[1,4]苯并硫氮杂。