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公开(公告)号:US20060003412A1
公开(公告)日:2006-01-05
申请号:US11149943
申请日:2005-06-09
申请人: Aaron Chamberlain , John Desjarlais
发明人: Aaron Chamberlain , John Desjarlais
CPC分类号: C07K16/465 , C07K16/00 , C07K16/3015 , C07K16/32 , C07K2317/565 , C07K2317/567 , G16B15/00 , G16B20/00 , G16B30/00
摘要: The invention relates to novel methods for engineering protein sequences using structural and homology information.
摘要翻译: 本发明涉及使用结构和同源性信息来工程化蛋白质序列的新方法。
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公开(公告)号:US20050181994A1
公开(公告)日:2005-08-18
申请号:US10952493
申请日:2004-10-12
IPC分类号: A61K38/00 , C07K14/525 , C07K14/705 , A61K38/17 , C07K14/74
CPC分类号: C07K14/525 , A61K38/00 , C07K14/70575 , C07K2319/00
摘要: The present invention relates to soluble, recombinant CD40L variant proteins that may be expressed solubly in E. coli. The variants of the present invention may substantially reduced binding to alpha IIb-beta3 integrin, act as CD40L antagonists or agonists, and methods for generating the same.
摘要翻译: 本发明涉及可溶于大肠杆菌中的可溶性重组CD40L变体蛋白。 本发明的变体可以显着降低与作为CD40L拮抗剂或激动剂的αIIb-β3整联蛋白的结合,以及用于产生它们的方法。
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公开(公告)号:US20070161783A1
公开(公告)日:2007-07-12
申请号:US11484183
申请日:2006-07-10
IPC分类号: C07K16/24
CPC分类号: C07K16/30 , C07K16/465 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/92
摘要: Humanized Ep-CAM-targeting antibodies and methods of making and using the same are provided.
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公开(公告)号:US20060074225A1
公开(公告)日:2006-04-06
申请号:US11228026
申请日:2005-09-14
申请人: Aaron Chamberlain , John Desjarlais
发明人: Aaron Chamberlain , John Desjarlais
IPC分类号: C07K16/18
CPC分类号: C07K16/44 , C07K16/00 , C07K2317/52
摘要: Design and production of immunoglobulin Fc domains including variants to stabilize their monomeric forms are provided.
摘要翻译: 提供了包括稳定其单体形式的变体的免疫球蛋白Fc结构域的设计和生产。
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公开(公告)号:US20070135620A1
公开(公告)日:2007-06-14
申请号:US11436266
申请日:2006-05-17
申请人: Aaron Chamberlain , John Desjarlais , Sher Karki , Gregory Lazar , Jost Vielmetter , Sean Yoder
发明人: Aaron Chamberlain , John Desjarlais , Sher Karki , Gregory Lazar , Jost Vielmetter , Sean Yoder
CPC分类号: C07K16/32 , C07K2317/52 , C07K2317/72
摘要: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
摘要翻译: 本申请涉及优化的IgG免疫球蛋白变体,其产生的工程方法及其应用,特别是用于治疗目的。
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公开(公告)号:US20070122406A1
公开(公告)日:2007-05-31
申请号:US11484198
申请日:2006-07-10
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K16/30 , C07K16/465 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/92
摘要: Humanized Ep-CAM-targeting antibodies and methods of making and using the same are provided.
摘要翻译: 提供了人源化的Ep-CAM靶向抗体及其制备和使用方法。
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公开(公告)号:US20060173170A1
公开(公告)日:2006-08-03
申请号:US11274065
申请日:2005-11-14
申请人: Aaron Chamberlain , John Desjarlais , Sher Karki , Gregory Lazar , Jost Vielmetter , Sean Yoder
发明人: Aaron Chamberlain , John Desjarlais , Sher Karki , Gregory Lazar , Jost Vielmetter , Sean Yoder
IPC分类号: C07K16/44
CPC分类号: C07K16/32 , C07K16/2878 , C07K16/2893 , C07K2317/24 , C07K2317/52 , C07K2317/526 , C07K2317/71 , C07K2317/72 , C07K2317/92 , C07K2317/94
摘要: The present application relates to optimized IgG immunoglobulin engineering methods for their generation, and their application, particularly for therapeutic purposes.
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