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公开(公告)号:US20070036865A1
公开(公告)日:2007-02-15
申请号:US11533115
申请日:2006-09-19
申请人: David Rozema , Darren Wakefield , Jon Wolff , Vladimir Budker , Tatyana Budker , Sean Monahan , Vladimir Trubetskoy , James Hagstrom , Aaton Loomis , Paul Slattum
发明人: David Rozema , Darren Wakefield , Jon Wolff , Vladimir Budker , Tatyana Budker , Sean Monahan , Vladimir Trubetskoy , James Hagstrom , Aaton Loomis , Paul Slattum
摘要: We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.
摘要翻译: 我们描述了pH敏感的内分泌溶解聚合物,包含pH敏感的内分解溶解聚合物的递送颗粒。 所述的颗粒能够将多核苷酸递送至来自外周循环的细胞,随后从内体释放。 内细胞分解的聚合物在细胞外是无活性的,但在暴露于酸化的内体室时破坏膜。