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公开(公告)号：US20060246078A1
公开(公告)日：2006-11-02
申请号：US11483745
申请日：2006-07-11
IPC分类号： A61K39/395
CPC分类号： C07K14/4702 , A61K2039/505 , C07K16/18 , C07K16/26 , C07K16/2869 , C12N15/1055 , G01N2500/02
摘要： The present invention also provides a method for screening and isolating transcriptional coregulatory proteins of transcription factors. Using this method, a new class of proteins, androgen receptor transcriptional coregulatory proteins, that interact with the androgen receptor N-terminus to regulate transcriptional activation, which are targets for identifying and isolating inhibitors that disrupt such an interaction, were identified.
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2.发明申请Method for screening transcriptional coregulatory proteins of transcription factors, and androgen receptor transcriptional coregulatory proteins as targets for androgen receptor-dependent diseases 审中-公开筛选转录因子转录调控蛋白的方法，以及雄激素受体转录调控蛋白作为雄激素受体依赖性疾病的靶标公开(公告)号：US20050180976A1
公开(公告)日：2005-08-18
申请号：US11097274
申请日：2005-04-04
IPC分类号： C07K14/47 , C07K16/18 , C07K16/28 , C12N15/10 , A61K39/395
CPC分类号： C07K14/4702 , A61K2039/505 , C07K16/18 , C07K16/26 , C07K16/2869 , C12N15/1055 , G01N2500/02
摘要： The present invention also provides a method for screening and isolating transcriptional coregulatory proteins of transcription factors. Using this method, a new class of proteins, androgen receptor transcriptional coregulatory proteins, that interact with the androgen receptor N-terminus to regulate transcriptional activation, which are targets for identifying and isolating inhibitors that disrupt such an interaction, were identified.
摘要翻译： 本发明还提供了筛选和分离转录因子转录调节蛋白的方法。 使用这种方法，确定了与雄激素受体N末端相互作用以调节转录激活的新一类蛋白质，即雄激素受体转录调控蛋白，其是用于鉴定和分离破坏这种相互作用的抑制剂的靶标。
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3.发明申请METHOD FOR SCREENING TRANSCRIPTIONAL COREGULATORY PROTEINS OF TRANSCRIPTION FACTORS, AND ANDROGEN RECEPTOR TRANSCRIPTIONAL COREGULATORY PROTEINS AS TARGETS FOR ANDROGEN RECEPTOR-DEPENDENT DISEASES 审中-公开用于筛选转录因子的转录调节蛋白的方法，以及作为雄激素受体依赖性疾病的靶标的雄激素受体转录蛋白公开(公告)号：US20080081903A1
公开(公告)日：2008-04-03
申请号：US11846177
申请日：2007-08-28
IPC分类号： C07H21/02
CPC分类号： C07K14/4702 , A61K2039/505 , C07K16/18 , C07K16/26 , C07K16/2869 , C12N15/1055 , G01N2500/02
摘要： The present invention also provides a method for screening and isolating transcriptional coregulatory proteins of transcription factors. Using this method, a new class of proteins, androgen receptor transcriptional coregulatory proteins, that interact with the androgen receptor N-terminus to regulate transcriptional activation, which are targets for identifying and isolating inhibitors that disrupt such an interaction, were identified.
摘要翻译： 本发明还提供了筛选和分离转录因子转录调节蛋白的方法。 使用这种方法，确定了与雄激素受体N末端相互作用以调节转录激活的新一类蛋白质，即雄激素受体转录调控蛋白，其是用于鉴定和分离破坏这种相互作用的抑制剂的靶标。
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