公开(公告)号：US20130143949A1

公开(公告)日：2013-06-06

申请号：US13461610

申请日：2012-05-01

申请人： Wei-Chiang SHEN ,  Yun BAI ,  David ANN ,  Adam WIDER

发明人： Wei-Chiang SHEN ,  Yun BAI ,  David ANN ,  Adam WIDER

IPC分类号： C07K19/00

CPC分类号： C07K19/00 ,  A61K38/193 ,  A61K47/644 ,  C07K14/535 ,  C07K14/79 ,  C07K2319/10 ,  C07K2319/74

摘要： A polypeptide comprising a G-CSF domain operably linked to a Tf domain, wherein the ability of the polypeptide to be transported into a cell expressing a TfR gene or the ability of the polypeptide to be transported across a cell expressing a TfR gene via transcytosis is higher than that of the G-CSF domain alone.