公开(公告)号：US20230018939A1

公开(公告)日：2023-01-19

申请号：US17778999

申请日：2020-11-20

申请人： Mark A. Brower ,  Jayesh Desai ,  Nuno Jorge Dos Santos Pinto ,  Zachary D. Dunn ,  Adrian Gospodarek ,  Xiaoqing Hua ,  Bhumit A. Patel ,  Douglas D. Richardson, II ,  Merck Sharp & Dohme LLC

发明人： Mark A. Brower ,  Jayesh Desai ,  Nuno Jorge Dos Santos Pinto ,  Zachary D. Dunn ,  Adrian Gospodarek ,  Xiaoqing Hua ,  Bhumit A. Patel ,  Douglas D. Richardson, II

IPC分类号： G01N30/88 ,  G01N30/24 ,  G01N30/14

摘要： The present invention relates to a method of measuring at least one product quality attributes, including critical quality attributes (e.g., oxidation, C-terminal lysine, aggregation, N-terminal glutamine cyclization.) by an online liquid chromatography system, wherein the liquid chromatography system is running a hydrophobic interaction chromatography (HIC) method.