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公开(公告)号：US20120237500A1
公开(公告)日：2012-09-20
申请号：US13482432
申请日：2012-05-29
Applicant: Cesar Milstein , Celia Prilleltensky-Milstein , Charles Nicholas Hales , Margaret Hales , Adrian Woolfson
Inventor： Cesar Milstein , Celia Prilleltensky-Milstein , Charles Nicholas Hales , Margaret Hales , Adrian Woolfson
IPC: A61K39/395 , C40B40/10
CPC classification number: G01N33/54306 , G01N33/68 , G01N33/6803 , G01N33/6845 , G06Q50/24 , Y02A90/22
Abstract: This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the detection and analysis of soluble CD antigens in a body fluid sample.
Abstract translation: 本发明涉及通过检测和分析体液样品中的可溶性CD抗原来测试，诊断，监测，预测分层和分类疾病，病症和其他医学状况和生理状态的方法。
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Patent Agency Ranking
公开(公告)号：US20080318836A1
公开(公告)日：2008-12-25
申请号：US12079894
申请日：2008-03-28
Applicant: Adrian Woolfson , Charles Nicholas Hales , Margaret Hales , Cesar Milstein , Celia Prilleltensky Milstein
Inventor： Adrian Woolfson , Charles Nicholas Hales , Margaret Hales , Cesar Milstein , Celia Prilleltensky Milstein
CPC classification number: G01N33/54306 , G01N33/68 , G01N33/6803 , G01N33/6845 , G06Q50/24 , Y02A90/22
Abstract: The present invention relates to the use of cluster of differentiation (CD) molecules in detecting the presence and progression of one or more disease states in an individual. In particular it relates to the use of profiles of shed CD (sCD) molecules in detecting an assessing the progress of one or more disease states in an individual. Further uses of sCD profiles according to the present invention are also described.
Abstract translation: 本发明涉及分化（CD）分子簇在检测个体中一种或多种疾病状态的存在和进展的用途。 特别地，它涉及使用脱落CD（sCD）分子的特征来检测评估个体中一种或多种疾病状态的进展。 还描述了根据本发明的sCD剖面的进一步使用。
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公开(公告)号：US08206907B2
公开(公告)日：2012-06-26
申请号：US12237915
申请日：2008-09-25
Applicant: Cesar Milstein , Celia Prilleltensky-Milstein, legal representative , Charles Nicholas Hales , Margaret Hales, legal representative , Adrian Woolfson
Inventor： Cesar Milstein , Charles Nicholas Hales , Adrian Woolfson
IPC: C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/574 , G01N33/68
CPC classification number: G01N33/54306 , G01N33/68 , G01N33/6803 , G01N33/6845 , G06F19/00 , G06Q50/24 , Y02A90/22
Abstract: This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the detection and analysis of soluble CD antigens in a body fluid sample.
Abstract translation: 本发明涉及通过检测和分析体液样品中的可溶性CD抗原来测试，诊断，监测，预测分层和分类疾病，病症和其他医学状况和生理状态的方法。
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公开(公告)号：US20090181863A1
公开(公告)日：2009-07-16
申请号：US12237915
申请日：2008-09-25
Applicant: Cesar Milstein , Celia Prilleltensky-Milstein , Charles Nicholas Hales , Margaret Hales , Adrian Woolfson
Inventor： Cesar Milstein , Celia Prilleltensky-Milstein , Charles Nicholas Hales , Margaret Hales , Adrian Woolfson
IPC: C40B40/10 , G01N33/543 , G01N33/53 , C12Q1/68 , G01N33/552
CPC classification number: G01N33/54306 , G01N33/68 , G01N33/6803 , G01N33/6845 , G06F19/00 , G06Q50/24 , Y02A90/22
Abstract: This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the detection and analysis of soluble CD antigens in a body fluid sample.
Abstract translation: 本发明涉及通过检测和分析体液样品中的可溶性CD抗原来测试，诊断，监测，预测分层和分类疾病，病症和其他医学状况和生理状态的方法。
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公开(公告)号：US20180169232A1
公开(公告)日：2018-06-21
申请号：US15736615
申请日：2016-06-15
Applicant: Glen Ian ANDREWS , Shihao CHEN , Alessandra DI PIETRO , David FONTANA , Zelanna GOLDBERG , Chia-Yang LIN , Hua LONG , Marcella MARTIGNONI , Dimitry Serge Antotne NUYTEN , Aron David THALL , Adrian WOOLFSON , MERCK PATENT GMBH , PFIZER INC.
Inventor： Glen Ian ANDREWS , Shihao CHEN , Alessandra DI PIETRO , David FONTANA , Zelanna GOLDBERG , Chia-Yang LIN , Hua LONG , Marcella MARTIGNONI , Dimitry Serge Antoine NUYTEN , Aron David THALL , Adrian WOOLFSON
IPC: A61K39/395 , A61K31/4439 , C07K16/28 , C07K16/24 , A61K33/24 , A61K31/4184 , A61K31/706 , A61P35/00
CPC classification number: A61K39/3955 , A61K31/4184 , A61K31/4439 , A61K31/706 , A61K33/24 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/243 , C07K16/2827 , C07K16/2878 , C07K16/2887 , C07K2317/21 , C07K2317/76 , A61K2300/00
Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death Ligand 1 receptor (PD-L1) and another therapeutic agent, and the use of the combination therapies for the treatment of cancer.
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公开(公告)号：US20070233391A1
公开(公告)日：2007-10-04
申请号：US10506906
申请日：2003-03-07
Applicant: Cesar Milstein , Celia Milstein , Adrian Woolfson , Charles Hales , Margaret Hales
Inventor： Cesar Milstein , Celia Milstein , Adrian Woolfson , Charles Hales , Margaret Hales
CPC classification number: G01N33/54306 , G01N33/68 , G01N33/6803 , G01N33/6845 , G06Q50/24 , Y02A90/22
Abstract: The present invention relates to the use of cluster of differentiation (CD) molecules in detecting the presence and progression of one or more disease states in an individual. In particular it relates to the use of profiles of shed CD (sCD) molecules in detecting and assessing the progression of one or more disease states in an individual. Further uses of sCD profiles according to the present invention are also described.
Abstract translation: 本发明涉及分化（CD）分子簇在检测个体中一种或多种疾病状态的存在和进展的用途。 特别地，它涉及使用脱落CD（sCD）分子的分布来检测和评估个体中一种或多种疾病状态的进展。 还描述了根据本发明的sCD剖面的进一步使用。
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