公开(公告)号：US08784802B2

公开(公告)日：2014-07-22

申请号：US13063456

申请日：2009-09-14

申请人： Paul R. Sanberg ,  Nelson Americo Hossne, Jr. ,  Alison E. Willing ,  Adriana Invitti

发明人： Paul R. Sanberg ,  Nelson Americo Hossne, Jr. ,  Alison E. Willing ,  Adriana Invitti

IPC分类号： A61K35/14

CPC分类号： A61K35/15 ,  A61K35/44 ,  A61K2035/124 ,  C12N5/0634 ,  C12N5/0645

摘要： The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the present invention provides methods of treating disorders by administering monocytes obtained from blood, including umbilical cord blood, peripheral blood, or bone marrow to an individual in need of treatment, wherein the drug is administered to the individual at a time point specifically determined to provide therapeutic efficacy. In one embodiment, the cells are for injection into ischemic myocardium for the treatment of angina.

摘要翻译： 本发明涉及用于治疗缺血性疾病和病症，特别是心肌，CNS /脑和肢体缺血的组合物和方法。 更具体地，本发明提供了通过从需要治疗的个体施用从血液（包括脐带血，外周血或骨髓）获得的单核细胞来治疗疾病的方法，其中在具体时间点向个体施用药物 确定提供治疗功效。 在一个实施方案中，细胞用于注射到缺血心肌中用于治疗心绞痛。