公开(公告)号：US20080182848A1

公开(公告)日：2008-07-31

申请号：US11961673

申请日：2007-12-20

Applicant: Debashish Datta ,  Ajaysingh Rawat ,  Shardard N. Duche ,  E.K.S. Vijayakumar

Inventor： Debashish Datta ,  Ajaysingh Rawat ,  Shardard N. Duche ,  E.K.S. Vijayakumar

IPC: A61K31/4985 ,  C07D487/04 ,  A61P25/22 ,  A61P25/24 ,  A61P25/00

CPC classification number: C07D487/04

Abstract: The present invention relates to a process for optically resolving eszopiclone, comprising chiral chromatography. Preferably the process comprises a multi-column continuous process or a simulated moving bed process. Preferably the stationary phase used in the chiral chromatography process comprises an amylose or cellulose derivative of tris(3,5-dimethylphenyl carbamate), or an amylose derivative of tris-α-methylbenzylcarbamate. The process of the present invention has the advantage that it is high yielding and can be carried out on an industrial scale.The present invention also provides eszopiclone, or a pharmaceutically acceptable salt thereof, obtained by the chiral chromatography process. The eszopiclone or salt thereof is suitable for use as a medicament, for example, for the treatment of anxiety or insomnia.

Abstract translation: 本发明涉及一种光学拆分依佐氟龙的方法，包括手性色谱法。 优选地，该方法包括多塔连续方法或模拟移动床方法。 优选地，用于手性色谱法的固定相包括三（3,5-二甲基苯基氨基甲酸酯）的直链淀粉或纤维素衍生物，或三-α-甲基苄基氨基甲酸酯的直链淀粉衍生物。 本发明的方法具有高产量并且可以在工业规模上进行的优点。 本发明还提供了通过手性色谱法获得的依佐溴隆或其药学上可接受的盐。 右佐佐酮或其盐适合用作药物，例如用于治疗焦虑或失眠。