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1.发明授权公开(公告)号：US08809494B2
公开(公告)日：2014-08-19
申请号：US11718772
申请日：2005-11-17
IPC分类号： A61K38/00 , C07K1/00 , A61K39/015 , A61K39/00
CPC分类号： C07K14/445 , A61K38/00 , A61K39/00 , Y02A50/412
摘要： Isolated proteins and nucleic acid sequence encoding such protein that interacts with a red blood cell to be invaded by a malaria parasite and link with a component of the actin-myosin based machinery of the malaria parasite are provided. In addition methods for identifying agents which inhibit the function of these proteins as chemotherapeutic and/or immunologic agents for treatment and prevention of malaria infections are provided. Compositions for treatment and prevention of malaria infections and methods for preventing and treating malaria infections are also provided.
摘要翻译： 提供编码这种蛋白质的分离的蛋白质和核酸序列，其与红细胞相互作用以被疟原虫寄生并与疟原虫的肌动蛋白 - 肌球蛋白基机制的组分连接。 此外，提供了用于鉴定抑制这些蛋白质作为化学治疗和/或免疫剂用于治疗和预防疟疾感染的功能的药剂的方法。 还提供了治疗和预防疟疾感染的组合物和预防和治疗疟疾感染的方法。
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公开(公告)号：US08486987B2
公开(公告)日：2013-07-16
申请号：US12743306
申请日：2008-11-16
IPC分类号： A61K31/415 , A61P33/02
CPC分类号： A61K31/41 , Y02A50/411
摘要： Methods for preventing or treating an Apicomplexan parasite infection in a patient administering to a patient in need thereof an effective amount of a compound of Formulas I-IV.
摘要翻译： 用于预防或治疗在有需要的患者中施用有效量的式I-IV化合物的患者中的Apicomplexan寄生虫感染的方法。
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3.发明申请公开(公告)号：US20080274113A1
公开(公告)日：2008-11-06
申请号：US11718772
申请日：2005-11-17
IPC分类号： A61K39/395 , C07K14/445 , C12N15/12 , C07K16/20 , G01N33/53 , A61K39/015
CPC分类号： C07K14/445 , A61K38/00 , A61K39/00 , Y02A50/412
摘要： Isolated proteins and nucleic acid sequence encoding such protein that interacts with a red blood cell to be invaded by a malaria parasite and link with a component of the actin-myosin based machinery of the malaria parasite are provided. In addition methods for identifying agents which inhibit the function of these proteins as chemotherapeutic and/or immunologic agents for treatment and prevention of malaria infections are provided. Compositions for treatment and prevention of malaria infections and methods for preventing and treating malaria infections are also provided.
摘要翻译： 提供编码这种蛋白质的分离的蛋白质和核酸序列，其与红细胞相互作用以被疟原虫寄生并与疟原虫的肌动蛋白 - 肌球蛋白基机制的组分连接。 此外，提供了用于鉴定抑制这些蛋白质作为化学治疗和/或免疫剂用于治疗和预防疟疾感染的功能的药剂的方法。 还提供了治疗和预防疟疾感染的组合物和预防和治疗疟疾感染的方法。
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公开(公告)号：US20110172268A1
公开(公告)日：2011-07-14
申请号：US12743306
申请日：2008-11-16
IPC分类号： A61K31/4709 , A61P33/02 , A61P33/06 , A61K31/4192 , A61K31/415 , A61K31/497
CPC分类号： A61K31/41 , Y02A50/411
摘要： Methods for preventing or treating an Apicomplexan parasite infection in a patient administering to a patient in need thereof an effective amount of a compound of Formulas I-IV.
摘要翻译： 用于预防或治疗在有需要的患者中施用有效量的式I-IV化合物的患者中的Apicomplexan寄生虫感染的方法。
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