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1.发明申请Polynucleotide Participating In Rheumatoid Arthritis And Utilization Of The Same 有权多核苷酸参与类风湿关节炎及其利用公开(公告)号：US20090035752A1
公开(公告)日：2009-02-05
申请号：US10590823
申请日：2004-11-25
CPC分类号： C12Q1/6883 , C12Q2600/154 , C12Q2600/158
摘要： Analysis is made on the DNA methylation of the region (including a promoter region) upstream from the translation initiation point of a rheumatoid arthritis-associated gene DR3 in human genome. As a result, it is found out that an allele-specific methylation occurs in a CpG sequence located about −380 to −180 bp upstream from translation initiation point (ATG) of the gene DR3. It is further found out that the CpG sequences downstream therefrom of the genes DR3 originating in healthy subjects are all in the unmethylated state, while methylated and unmethylated sequences are both observed in the genes DR3 originating in RA patients.
摘要翻译： 对人类基因组中类风湿性关节炎相关基因DR3的翻译起始点上游的区域（包括启动子区域）的DNA甲基化进行分析。 结果发现等位基因特异性甲基化发生在位于基因DR3的翻译起始点（ATG）上游约-380至-180bp的CpG序列中。 进一步发现源自健康受试者的基因DR3下游的CpG序列都处于非甲基化状态，而在来自RA患者的基因DR3中都观察到甲基化和未甲基化的序列。
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公开(公告)号：US07741030B2
公开(公告)日：2010-06-22
申请号：US10590823
申请日：2004-11-25
CPC分类号： C12Q1/6883 , C12Q2600/154 , C12Q2600/158
摘要： Analysis is made on the DNA methylation of the region (including a promoter region) upstream from the translation initiation point of a rheumatoid arthritis-associated gene DR3 in human genome. As a result, it is found out that an allele-specific methylation occurs in a CpG sequence located about −380 to −180 bp upstream from translation initiation point (ATG) of the gene DR3. It is further found out that the CpG sequences downstream therefrom of the genes DR3 originating in healthy subjects are all in the unmethylated state, while methylated and unmethylated sequences are both observed in the genes DR3 originating in RA patients.
摘要翻译： 对人类基因组中类风湿性关节炎相关基因DR3的翻译起始点上游的区域（包括启动子区域）的DNA甲基化进行分析。 结果发现等位基因特异性甲基化发生在位于基因DR3的翻译起始点（ATG）上游约-380至-180bp的CpG序列中。 进一步发现源自健康受试者的基因DR3下游的CpG序列都处于非甲基化状态，而在来自RA患者的基因DR3中都观察到甲基化和未甲基化的序列。
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