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    Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient
    2.
    发明授权
    Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient 失效
    神经再生启动子含有信号素抑制剂作为活性成分

    公开(公告)号：US07317038B2

    公开(公告)日：2008-01-08

    申请号：US11508965

    申请日：2006-08-24

    申请人： Toru Kimura ,  Kaoru Kikuchi ,  Kazuo Kumagai ,  Nobuo Hosotani ,  Akiyoshi Kishino

    发明人： Toru Kimura ,  Kaoru Kikuchi ,  Kazuo Kumagai ,  Nobuo Hosotani ,  Akiyoshi Kishino

    IPC分类号： A61K31/405 ,  C07D311/80 ,  C07D311/00 ,  C12Q1/50

    CPC分类号： C07D493/04 ,  C07D311/78 ,  C07D311/86

    摘要： To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like.A low-molecular weight compound, which acts at a concentration of 10 μg/ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and/or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action.

    摘要翻译： 提供信号素抑制剂; 包含所述信号素抑制剂作为活性成分的外周或中枢神经再生促进剂; 以及包含所述神经再生促进剂的神经病和神经变性疾病的预防或治疗方法等。 低分子量化合物以10ug / ml或更低的浓度起作用以抑制semaphorin如semaphorin 3A，semaphorin 6C等信号素的生长锥塌陷活性和/或信号素在神经生长抑制活性中的作用 胶原凝胶，其基本上不影响细胞增殖，从属于青霉属的菌株SPF-3059的培养物获得。 由此获得的具有信号素抑制活性的低分子化合物表现出体内神经再生促进作用。

    Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient
    6.
    发明授权
    Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient 有权
    神经再生启动子含有信号素抑制剂作为活性成分

    公开(公告)号：US07244761B2

    公开(公告)日：2007-07-17

    申请号：US10343125

    申请日：2001-07-27

    申请人： Toru Kimura ,  Kaoru Kikuchi ,  Kazuo Kumagai ,  Nobuo Hosotani ,  Akiyoshi Kishino

    发明人： Toru Kimura ,  Kaoru Kikuchi ,  Kazuo Kumagai ,  Nobuo Hosotani ,  Akiyoshi Kishino

    IPC分类号： A61K31/405 ,  C07D311/80 ,  C07D311/00 ,  C12Q1/50

    CPC分类号： C07D493/04 ,  C07D311/78 ,  C07D311/86

    摘要： To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like.A low-molecular weight compound, which acts at a concentration of 10 μg/ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and/or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action.

    摘要翻译： 提供信号素抑制剂; 包含所述信号素抑制剂作为活性成分的外周或中枢神经再生促进剂; 以及包含所述神经再生促进剂的神经病和神经变性疾病的预防或治疗方法等。 低分子量化合物以10ug / ml或更低的浓度起作用以抑制semaphorin如semaphorin 3A，semaphorin 6C等信号素的生长锥塌陷活性和/或信号素在神经生长抑制活性中的作用 胶原凝胶，其基本上不影响细胞增殖，从属于青霉属的菌株SPF-3059的培养物获得。 由此获得的具有信号素抑制活性的低分子量化合物表现出体内神经再生促进作用。