公开(公告)号：US06448472B1

公开(公告)日：2002-09-10

申请号：US09244791

申请日：1999-02-05

Applicant: Collin E. Thomas ,  J. Brian Windsor ,  Stan J. Roux ,  Alan M. Lloyd

Inventor： Collin E. Thomas ,  J. Brian Windsor ,  Stan J. Roux ,  Alan M. Lloyd

IPC: C12N1582

CPC classification number: C12N15/8274 ,  A61K48/00 ,  C07K14/415 ,  C12N9/14

Abstract: The present invention relates to methods for modulating the resistance of cells to foreign compounds, i.e. drugs, antibiotics, etc by altering the ATP gradient across biological membranes. The altering of the ATP gradient across biological membranes is achieved through the manipulation of ecto-phosphatase activity and ABC transporter molecule activity which may be useful to confer herbicide resistance to plants, confer antibiotic resistance to bacteria, confer drug resistance to yeast cells, or to reduce resistance in cells to facilitate chemotherapeutic treatments, and to reduce resistance in bacteria and yeast to aid in the treatment of certain infections and disease.

Abstract translation: 本发明涉及通过改变生物膜上的ATP梯度来调节细胞对外来化合物（即药物，抗生素等）的抗性的方法。 跨越生物膜的ATP梯度的改变通过操作外源磷酸酶活性和ABC转运蛋白分子活性来实现，其可用于赋予对植物的除草剂抗性，赋予对细菌的抗生素抗性，赋予酵母细胞耐药性，或 降低细胞中的抗性以促进化学治疗，并降低细菌和酵母中的抗性，以帮助治疗某些感染和疾病。

公开(公告)号：USD303005S

公开(公告)日：1989-08-22

申请号：US121770

申请日：1987-11-13

Applicant: Alan M. Lloyd ,  Alan Constable ,  Martin L. Smith

Designer： Alan M. Lloyd ,  Alan Constable ,  Martin L. Smith

公开(公告)号：US4951650A

公开(公告)日：1990-08-28

申请号：US322072

申请日：1989-03-10

Applicant: Michael Boyes ,  Alan M. Lloyd ,  Martin L. Smith ,  Alan Constable

Inventor： Michael Boyes ,  Alan M. Lloyd ,  Martin L. Smith ,  Alan Constable

IPC: F24C3/00

CPC classification number: F24C3/006

Abstract: A gas fire appliance having a casing with a rear face at which a plurality of alumina flame effect burner tubes are supported, the tubes extending through a ceramic deflector plate supported over the rear face and lying behind a solid fuel simulating element which is relatively steeply raked to be visible through an adjacent front glass panel of the appliance. A dual-section main heater burner with a pair of metallic flame effect burners secured to one side thereof is positioned below the solid fuel simulating element, the flames therefrom being deflected upwardly by the plate. A gas control knob is operable to turn on all the burners or to select various ones thereof only as required. The steep rake of the fuel bed ensures that the visual appearance of the appliance is enhanced by fully presenting the working area and the alumina burner tubes positioned in the high temperature fuel bed ensure an effective living flame effect of high efficiency.

Abstract translation: 一种具有壳体的燃气消防设备，其具有支撑多个氧化铝火焰效果燃烧器管的后表面，所述管延伸穿过陶瓷偏转板，所述陶瓷偏转板支撑在后表面上并且位于固体燃料模拟元件的后面，所述固体燃料模拟元件相对陡峭地倾斜 通过设备的相邻前玻璃面板可见。 固定在其一侧的具有一对金属火焰效果燃烧器的双截面主加热器燃烧器位于固体燃料模拟元件的下方，其中的火焰被板向上偏转。 气体控制旋钮可操作以打开所有燃烧器或仅根据需要选择其中的各种燃烧器。 燃料床的陡峭的耙子通过充分呈现位于高温燃料床中的工作区域和氧化铝燃烧器管来确保设备的视觉外观，确保高效率的有效的活火焰效果。