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1.发明授权Utilization of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factors NF-&kgr;&bgr; 失效利用2-羟基-4-三氟甲基苯甲酸衍生物作为核转录因子NF-κB活化的抑制剂公开(公告)号：US06414025B1
公开(公告)日：2002-07-02
申请号：US09701270
申请日：2001-02-20
申请人： Manuel Merlos Roca , Alberto Fernandez De Arriba , Fernando Cavalcanti De Maria , Agustí Miralles Acosta , Mariano Sanchez Crespo , Julián Garcia Rafanell , Javier Forn Dalmau
发明人： Manuel Merlos Roca , Alberto Fernandez De Arriba , Fernando Cavalcanti De Maria , Agustí Miralles Acosta , Mariano Sanchez Crespo , Julián Garcia Rafanell , Javier Forn Dalmau
IPC分类号： A61K3160
CPC分类号： A61K31/222 , A61K31/192 , A61K31/60 , Y02A50/411
摘要： The invention relates to the use of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-&kgr;B. The invention also relates to the utilization of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives for the preparation of medicaments to treat or prevent of pathologies associated to the activation of NF-&kgr;B and/or the expression of genes which are dependent on or regulated by, at least partially, NF&kgr;B in mammals, including humans.
摘要翻译： 本发明涉及2-羟基-4-三氟甲基苯甲酸衍生物作为激活核转录因子NF-κB的抑制剂的用途。 本发明还涉及2-羟基-4-三氟甲基苯甲酸衍生物用于制备药物以治疗或预防与NF-κB活化有关的病理学和/或依赖于或受其调节的基因的表达 ，至少部分为哺乳动物，包括人类的NFkappaB。
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2.发明授权Use of 2-hydroxy-4-trifluoromethyl-benzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-KS 失效使用2-羟基-4-三氟甲基 - 苯甲酸衍生物作为激活核转录因子NF-KS的抑制剂公开(公告)号：US06610745B2
公开(公告)日：2003-08-26
申请号：US10115140
申请日：2002-04-04
申请人： Manuel Merlos Roca , Alberto Fernandez De Arriba , Fernando Cavalcanti De Maria , Agustí Miralles Acosta , Mariano Sanchez Crespo , Julián Garcia Rafanell , Javier Forn Dalmau
发明人： Manuel Merlos Roca , Alberto Fernandez De Arriba , Fernando Cavalcanti De Maria , Agustí Miralles Acosta , Mariano Sanchez Crespo , Julián Garcia Rafanell , Javier Forn Dalmau
IPC分类号： A61K3160
CPC分类号： A61K31/222 , A61K31/192 , A61K31/60 , Y02A50/411
摘要： Neurodegenerative diseases, such as dementia, including Alzheimer's disease, can be treated or prevented by administering an effective amount of triflusal or its metabolite, or a pharmaceutically acceptable salt or a prodrug thereof.
摘要翻译： 可以通过施用有效量的三氟甲磺酸或其代谢物或其药学上可接受的盐或前药来治疗或预防神经变性疾病，例如痴呆，包括阿尔茨海默氏病。
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公开(公告)号：US20050267205A1
公开(公告)日：2005-12-01
申请号：US10521461
申请日：2003-07-17
IPC分类号： A61P1/04 , A61K31/192 , A61K31/235 , A61P3/10 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/08 , A61P21/00 , A61P25/00 , A61P27/16 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07C65/21 , C07C69/92 , A61K31/277 , A61K31/195
摘要： The present invention relates to novel compounds of formula (I) and to the salts, solvates and prodrugs thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful for the treatment or prevention of psoriasis and other immune diseases.
摘要翻译： 本发明涉及新的式（I）化合物及其盐，溶剂化物和前体药物，其中各种取代基的含义如说明书中所公开的。 所述化合物可用于治疗或预防牛皮癣和其他免疫疾病。
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4.发明授权Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-&kgr;B 失效使用2-羟基-4-三氟甲基苯甲酸衍生物作为激活核转录因子NF-κB的抑制剂公开(公告)号：US06509377B1
公开(公告)日：2003-01-21
申请号：US10118160
申请日：2002-04-09
申请人： Manuel Merlos Roca , Alberto Fernandez De Arriba , Fernando Cavalcanti De Maria , Agustí Miralles Acosta , Mariano Sanchez Crespo , Julián Garcia Rafanell , Javier Forn Dalmau
发明人： Manuel Merlos Roca , Alberto Fernandez De Arriba , Fernando Cavalcanti De Maria , Agustí Miralles Acosta , Mariano Sanchez Crespo , Julián Garcia Rafanell , Javier Forn Dalmau
IPC分类号： A61K3160
CPC分类号： A61K31/222 , A61K31/192
摘要： A method for inhibiting the activation of transcription factor NF-&kgr;B in a warm-blooded animal in need thereof, comprises administering to said animal an effective amount of a compound of formula I wherein R represents hydrogen or COCH3, or a pharmaceutically acceptable salt or a prodrug thereof.
摘要翻译： 一种抑制有需要的温血动物中转录因子NF-κB活化的方法包括向所述动物施用有效量的式I化合物，其中R表示氢或COCH 3，或其药学上可接受的盐或前药 其中。
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