公开(公告)号：US10293128B2

公开(公告)日：2019-05-21

申请号：US14602991

申请日：2015-01-22

申请人： Jeffrey S. Wolf ,  Aldo T. Iacono

发明人： Jeffrey S. Wolf ,  Aldo T. Iacono

IPC分类号： A61M16/00 ,  A61M16/04 ,  A61B17/34 ,  A61M25/00

摘要： Techniques for emergency apneic oxygenation include a cannula having a longitudinal inner passage with an inner diameter. A distal portion has a first outer diameter greater than the inner diameter, and is made of shape memory material shaped to bend in a first direction along the inner passage. A cannula base has a second outer diameter greater than the first outer diameter. A distance from a distal end of the cannula to a proximal end of the distal portion of the cannula is less than a distance from a surface of a throat of a subject to a distal surface of an airway of the subject. The inner passage is configured to pass a catheter connected at a proximal end to an oxygen source. In various embodiments, the cannula is used with a trocar and, optionally, a system base, or supplied in a kit with a catheter.

公开(公告)号：US20150182716A1

公开(公告)日：2015-07-02

申请号：US14602991

申请日：2015-01-22

申请人： Jeffrey S. Wolf ,  Aldo T. Iacono

发明人： Jeffrey S. Wolf ,  Aldo T. Iacono

IPC分类号： A61M16/04 ,  A61B17/34 ,  A61B1/06

CPC分类号： A61M16/0472 ,  A61B17/3415 ,  A61M16/0463 ,  A61M16/047 ,  A61M16/0486 ,  A61M25/00

摘要： Techniques for emergency apneic oxygenation include a cannula having a longitudinal inner passage with an inner diameter. A distal portion has a first outer diameter greater than the inner diameter, and is made of shape memory material shaped to bend in a first direction along the inner passage. A cannula base has a second outer diameter greater than the first outer diameter. A distance from a distal end of the cannula to a proximal end of the distal portion of the cannula is less than a distance from a surface of a throat of a subject to a distal surface of an airway of the subject. The inner passage is configured to pass a catheter connected at a proximal end to an oxygen source. In various embodiments, the cannula is used with a trocar and, optionally, a system base, or supplied in a kit with a catheter.

摘要翻译： 用于紧急呼吸暂停充氧的技术包括具有内径的纵向内部通道的套管。 远侧部分具有大于内径的第一外径，并且由形状记忆材料制成，以形成为沿着内部通道在第一方向上弯曲。 套管基座具有大于第一外径的第二外径。 从插管的远端到套管的远端部分的近端的距离小于从受试者的喉部的表面到受试者的气道的远端表面的距离。 内部通道构造成将在近端连接的导管通过氧源。 在各种实施例中，插管与套管针和任选的系统基座一起使用，或者在具有导管的套件中提供。

公开(公告)号：US20090263335A1

公开(公告)日：2009-10-22

申请号：US12433231

申请日：2009-04-30

申请人： ALDO T. IACONO

发明人： ALDO T. IACONO

IPC分类号： A61K9/12 ,  A61P37/06 ,  A61K38/13

CPC分类号： A61K38/13 ,  A61K9/0073 ,  Y10T428/2982 ,  A61K2300/00

摘要： The present invention relates to methods and compositions for prevention of graft rejection in lung transplant recipients and for treatment of subjects with pulmonary disorders. Specifically, the methods and compositions of the invention provide a means for inhibiting immune response mediated inflammatory processes in the lungs. The method of the invention comprises the administration of aerosolized cyclosporine for prevention of acute and/or chronic refractory rejection in lung transplant patients. The invention further provides for the use of aerosolized cyclosporine to treat subjects having immunologically mediated inflammatory pulmonary disorders including, but not limited to, asthma, cystic fibrosis, idiopathic pulmonary fibrosis, chronic bronchitis and allergic rhinitis. The present invention, by enabling a method for the use of aerosolized cyclosporine for inhibiting pulmonary inflammation leading to prevention of graft rejection and treatment of pulmonary disorders, provides a safer and less toxic treatment than those methods that utilize systemic administration of cyclosporine.

公开(公告)号：US20120189672A1

公开(公告)日：2012-07-26

申请号：US13439187

申请日：2012-04-04

申请人： Aldo T. Iacono ,  Bartley P. Griffith

发明人： Aldo T. Iacono ,  Bartley P. Griffith

IPC分类号： A61K38/13 ,  A61P11/00 ,  A61P29/00 ,  A61K9/14 ,  A61P37/06

CPC分类号： A61K38/13 ,  A61K9/0073 ,  Y10T428/2982 ,  A61K2300/00

摘要： The present invention relates to methods and compositions for prevention of graft rejection in lung transplant recipients and for treatment of subjects with pulmonary disorders. Specifically, the methods and compositions of the invention provide a means for inhibiting immune response mediated inflammatory processes in the lungs. The method of the invention comprises the administration of aerosolized cyclosporine for prevention of acute and/or chronic refractory rejection in lung transplant patients. The invention further provides for the use of aerosolized cyclosporine to treat subjects having immunologically mediated inflammatory pulmonary disorders including, but not limited to, asthma, cystic fibrosis, idiopathic pulmonary fibrosis, chronic bronchitis and allergic rhinitis. The present invention, by enabling a method for the use of aerosolized cyclosporine for inhibiting pulmonary inflammation leading to prevention of graft rejection and treatment of pulmonary disorders, provides a safer and less toxic treatment than those methods that utilize systemic administration of cyclosporine.

摘要翻译： 本发明涉及用于预防肺移植受体中的移植物排斥反应的方法和组合物以及用于治疗患有肺部疾病的受试者。 具体地，本发明的方法和组合物提供了一种用于抑制肺中免疫应答介导的炎症过程的手段。 本发明的方法包括施用雾化的环孢菌素以预防肺移植患者的急性和/或慢性难治性排斥反应。 本发明还提供了使用雾化的环孢菌素来治疗具有免疫介导的炎症性肺病的受试者，包括但不限于哮喘，囊性纤维化，特发性肺纤维化，慢性支气管炎和过敏性鼻炎。 本发明通过实现气雾化环孢菌素用于抑制肺部炎症导致预防移植物排斥反应和治疗肺部疾病的方法，提供比利用全身施用环孢菌素的那些方法更安全和更少毒性的治疗方法。

公开(公告)号：US08158110B2

公开(公告)日：2012-04-17

申请号：US12433231

申请日：2009-04-30

申请人： Aldo T. Iacono ,  Griffith Bartley

发明人： Aldo T. Iacono ,  Griffith Bartley

IPC分类号： A61K9/14 ,  A61K9/12 ,  A61K38/00 ,  A61K38/12

CPC分类号： A61K38/13 ,  A61K9/0073 ,  Y10T428/2982 ,  A61K2300/00

摘要： The present invention relates to methods and compositions for prevention of graft rejection in lung transplant recipients and for treatment of subjects with pulmonary disorders. Specifically, the methods and compositions of the invention provide a means for inhibiting immune response mediated inflammatory processes in the lungs. The method of the invention comprises the administration of aerosolized cyclosporine for prevention of acute and/or chronic refractory rejection in lung transplant patients. The invention further provides for the use of aerosolized cyclosporine to treat subjects having immunologically mediated inflammatory pulmonary disorders including, but not limited to, asthma, cystic fibrosis, idiopathic pulmonary fibrosis, chronic bronchitis and allergic rhinitis. The present invention, by enabling a method for the use of aerosolized cyclosporine for inhibiting pulmonary inflammation leading to prevention of graft rejection and treatment of pulmonary disorders, provides a safer and less toxic treatment than those methods that utilize systemic administration of cyclosporine.

摘要翻译： 本发明涉及用于预防肺移植受体中的移植物排斥反应的方法和组合物以及用于治疗患有肺部疾病的受试者。 具体地，本发明的方法和组合物提供了一种用于抑制肺中免疫应答介导的炎症过程的手段。 本发明的方法包括施用雾化的环孢菌素以预防肺移植患者的急性和/或慢性难治性排斥反应。 本发明还提供了使用雾化的环孢菌素来治疗具有免疫介导的炎症性肺病的受试者，包括但不限于哮喘，囊性纤维化，特发性肺纤维化，慢性支气管炎和过敏性鼻炎。 本发明通过实现气雾化环孢菌素用于抑制肺部炎症导致预防移植物排斥反应和治疗肺部疾病的方法，提供比利用全身施用环孢菌素的那些方法更安全和更少毒性的治疗方法。