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1.发明申请公开(公告)号：US20110288654A1
公开(公告)日：2011-11-24
申请号：US13108074
申请日：2011-05-16
IPC分类号： A61F2/04
CPC分类号： A61L27/3679 , A61F2/04 , A61F2002/044 , A61K35/38 , A61L27/362 , A61L27/3629 , A61L27/3633 , A61L27/3882 , A61L2430/22
摘要： Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.
摘要翻译： 提供用于植入患有至少部分食管的患者的医疗装置。 医疗装置将食道或其余部分与胃连接以形成胃食管连接处，其在分配负荷并减少吻合部位的张力的同时促进愈合并促进新的宿主组织生长。 医疗装置包括细胞外基质成形为更接近天然胃食管结合物的几何形状的构象，而不是将胃直接附着于缩短的食道。 在本文中还描述了用于制造医疗装置的模具和装置的使用方法。
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2.发明申请公开(公告)号：US20080109070A1
公开(公告)日：2008-05-08
申请号：US11837235
申请日：2007-08-10
申请人： William Wagner , John Stankus , Jianjun Guan , Kazuro Fujimoto , Alejandro Nieponice , Lorenzo Soletti , David Vorp , Michael Sacks , Todd Courtney , John Mayer
发明人： William Wagner , John Stankus , Jianjun Guan , Kazuro Fujimoto , Alejandro Nieponice , Lorenzo Soletti , David Vorp , Michael Sacks , Todd Courtney , John Mayer
CPC分类号： A61L27/3843 , A61F2/2415 , A61L27/54 , A61L27/56 , A61L2300/236 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602
摘要： Described herein are elastomeric materials, and in particular porous biodegradable elastomeric materials which optionally may have microintegrated cells. Also described herein are bioprosthetic devices that can be manufactured using the biodegradable elastomeric materials, non-limiting examples of such devices including pulmonary valves, vocal chords, and blood vessels.
摘要翻译： 本文描述的是弹性体材料，特别是多孔可生物降解的弹性体材料，其任选地可以具有微结合的细胞。 本文还描述了可以使用可生物降解的弹性体材料制造的生物假体装置，这种装置的非限制性实例包括肺动脉瓣，声带和血管。
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3.发明授权公开(公告)号：US08927003B2
公开(公告)日：2015-01-06
申请号：US13108074
申请日：2011-05-16
CPC分类号： A61L27/3679 , A61F2/04 , A61F2002/044 , A61K35/38 , A61L27/362 , A61L27/3629 , A61L27/3633 , A61L27/3882 , A61L2430/22
摘要： Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.
摘要翻译： 提供用于植入患有至少部分食管的患者的医疗装置。 医疗装置将食道或其余部分与胃连接以形成胃食管连接处，其在分配负荷并减少吻合部位的张力的同时促进愈合并促进新的宿主组织生长。 医疗装置包括细胞外基质成形为更接近天然胃食管结合物的几何形状的构象，而不是将胃直接附着于缩短的食道。 在本文中还描述了用于制造医疗装置的模具和装置的使用方法。
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4.发明申请公开(公告)号：US20070166396A1
公开(公告)日：2007-07-19
申请号：US11650015
申请日：2007-01-05
IPC分类号： A61K35/38
CPC分类号： A61L27/3679 , A61F2/04 , A61F2002/044 , A61K35/38 , A61L27/362 , A61L27/3629 , A61L27/3633 , A61L27/3882 , A61L2430/22
摘要： Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.
摘要翻译： 提供用于植入患有至少部分食管的患者的医疗装置。 医疗装置将食道或其余部分与胃连接以形成胃食管连接处，其在分配负荷并减少吻合部位的张力的同时促进愈合并促进新的宿主组织生长。 医疗装置包括细胞外基质成形为更接近天然胃食管结合物的几何形状的构象，而不是将胃直接附着于缩短的食道。 在本文中还描述了用于制造医疗装置的模具和装置的使用方法。
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公开(公告)号：US20060075963A1
公开(公告)日：2006-04-13
申请号：US11243818
申请日：2005-10-05
申请人： Alejandro Nieponice , David Vorp , Lorenzo Soletti
发明人： Alejandro Nieponice , David Vorp , Lorenzo Soletti
摘要： An apparatus for seeding material in a scaffold member capable of entrapping such seeding material therein is provided. The apparatus may include a chamber having an interior and capable of maintaining a negative pressure and capable of enclosing the scaffold member therein, and a support member for rotating the scaffold member disposed within the interior of the chamber and for introducing the seeding material into the chamber. At least a portion of rotating the scaffold member occurs simultaneously with applying the negative pressure condition to the scaffold member. The seeding material may be passed from the interior of the scaffold member to the exterior of the scaffold member in response to the application of negative pressure such that at least of portion of the seeding material is entrapped in the scaffold member.
摘要翻译： 提供了一种用于将材料接种在能够将这种种子材料包埋在其中的支架构件中的装置。 该装置可以包括具有内部并且能够保持负压并能够将支架构件包围在其中的腔室，以及用于旋转设置在腔室内部的支架构件并用于将种子材料引入腔室的支撑构件 。 旋转支架构件的至少一部分同时施加负压条件到脚手架构件。 响应于施加负压，播种材料可以从脚手架构件的内部通过到支架构件的外部，使得至少部分种子材料被截留在支架构件中。
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