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公开(公告)号:US20080299123A1
公开(公告)日:2008-12-04
申请号:US11868278
申请日:2007-10-05
IPC分类号: A61K39/395 , C07K16/18 , C07H21/02 , A61K31/711 , A61K33/24 , A61K31/7105 , C07H21/04
CPC分类号: C07K14/70503 , A61K2039/505 , C07K16/2803 , C07K2317/73 , C07K2317/76 , C12N15/1138 , C12N2310/14
摘要: The present invention relates to the use of L1 interfering molecules, especially anti-L1 antibodies, in tumor treatment. Especially, the present invention relates to the use of said L1 interfering molecules in sensitizing tumor cells for the treatment with chemotherapeutic drugs of with radiotherapy and to the combined administration of L1 interfering molecules with chemotherapeutic drugs or with radiotherapy.
摘要翻译: 本发明涉及L1干扰分子,特别是抗L1抗体在肿瘤治疗中的应用。 特别地,本发明涉及所述L1干扰分子在使肿瘤细胞敏化用于放射治疗的化学治疗药物以及将L1干扰分子与化学治疗药物或放射疗法联合给药时的用途。