公开(公告)号：US5346814A

公开(公告)日：1994-09-13

申请号：US961268

申请日：1992-10-14

申请人： George M. Hahn ,  Alie H. Saad ,  Amato J. Giaccia

发明人： George M. Hahn ,  Alie H. Saad ,  Amato J. Giaccia

IPC分类号： A61K49/00 ,  G01N33/487 ,  G01N33/50 ,  C12Q1/16 ,  G01N23/00

CPC分类号： G01N33/5011 ,  A61K49/0004 ,  G01N33/5005 ,  Y10S435/968

摘要： A method of assessing a cell's susceptibility to cell-damaging energy, such as ionizing radiation and heat, is disclosed. The method is based on measurable changes in voltage-dependent potassium channel currents in the cell in response to the energy. Also disclosed is a method for screening drugs which are effective to sensitize a cell to cell-damaging radiation.

摘要翻译： 公开了一种评估细胞对细胞损伤能量的敏感性的方法，例如电离辐射和热。 该方法基于响应于能量的电池中电压依赖性钾通道电流的可测量变化。 还公开了一种用于筛选有效使细胞对细胞破坏性辐射敏感的药物的方法。