公开(公告)号：US20060046259A1

公开(公告)日：2006-03-02

申请号：US11155835

申请日：2005-06-17

申请人： Alison Baird ,  David Moore ,  Ehud Goldin

发明人： Alison Baird ,  David Moore ,  Ehud Goldin

IPC分类号： C12Q1/68 ,  G01N33/00

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Methods are provided for evaluating a stroke, for example for determining whether a subject has had an ischemic stroke, determining the severity or likely neurological recovery of a subject who has had an ischemic stroke, and determining a treatment regimen for a subject who has had an ischemic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression in ischemic stroke related genes (or proteins), such as white blood cell activation and differentiation genes (or proteins), genes (or proteins) related to hypoxia, genes (or proteins) involved in vascular repair, and genes (or proteins) related to a specific peripheral blood mononuclear cell (PBMC) response to the altered cerebral microenvironment. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of an ischemic stroke-related molecule.

摘要翻译： 提供了用于评估中风的方法，例如用于确定受试者是否具有缺血性中风，确定患有缺血性中风的受试者的严重性或可能的神经恢复，以及确定已经具有缺血性卒中的受试者的治疗方案 缺血性中风，以及可用于实施该方法的阵列和试剂盒。 在具体实例中，该方法包括筛选缺血性卒中相关基因（或蛋白质）中的表达，例如白血细胞活化和分化基因（或蛋白质），与缺氧有关的基因（或蛋白质），参与的基因（或蛋白质） 血管修复和与特异性外周血单核细胞（PBMC）相关的基因（或蛋白质）对改变的脑微环境的反应。 还提供了鉴定改变缺血性卒中相关分子的活性（例如表达）的一种或多种试剂的方法。